Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro

por Brauer, Erik, Lange, Tobias, Keller, Daniela, Görlitz, Sophie, Cho, Simone, Keye, Jacqueline, Gossen, Manfred, Petersen, Ansgar, Kornak, Uwe
Publicado 2022

A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models

por Yau, Estelle, Gertz, Michael, Ogungbenro, Kayode, Aarons, Leon, Olivares‐Morales, Andrés
Publicado 2023

Disease progression modeling of the North Star Ambulatory Assessment for Duchenne Muscular Dystrophy

por Hibma, Jennifer E., Jayachandran, Priya, Neelakantan, Srividya, Harnisch, Lutz O.
Publicado 2023

DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice

por de Boer, Martine, te Lintel Hekkert, Maaike, Chang, Jiang, van Thiel, Bibi S., Martens, Leonie, Bos, Maxime M., de Kleijnen, Marion G. J., Ridwan, Yanto, Octavia, Yanti, van Deel, Elza D., Blonden, Lau A., Brandt, Renata M. C., Barnhoorn, Sander, Bautista‐Niño, Paula K., Krabbendam‐Peters, Ilona, Wolswinkel, Rianne, Arshi, Banafsheh, Ghanbari, Mohsen, Kupatt, Christian, de Windt, Leon J., Danser, A. H. Jan, van der Pluijm, Ingrid, Remme, Carol Ann, Stoll, Monika, Pothof, Joris, Roks, Anton J. M., Kavousi, Maryam, Essers, Jeroen, van der Velden, Jolanda, Hoeijmakers, Jan H. J., Duncker, Dirk J.
Publicado 2023

Investigation of simplified physiologically‐based pharmacokinetic models in rat and human

por Yau, Estelle, Olivares‐Morales, Andrés, Ogungbenro, Kayode, Aarons, Leon, Gertz, Michael
Publicado 2023

Protein phosphatase 2A activators reverse age‐related behavioral changes by targeting neural cell senescence

por Xing, Jun, Chen, Kehua, Gao, Shuaiyun, Pousse, Mélanie, Ying, Yilin, Wang, Bo, Chen, Lianxiang, Wang, Cuicui, Wang, Lei, Hu, Weiguo, Lu, Yiming, Gilson, Eric, Ye, Jing
Publicado 2023

Cell state‐directed therapy – epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide

por Saini, Anshul, Ballesta, Annabelle, Gallo, James M.
Publicado 2023

Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species

por Cordes, Henrik, Rapp, Hermann
Publicado 2023

Quantitative systems pharmacology of the eye: Tools and data for ocular QSP

por Kuepfer, Lars, Fuellen, Georg, Stahnke, Thomas
Publicado 2023

Age‐dependent NMDA receptor function is regulated by the amyloid precursor protein

por Rajão‐Saraiva, Joana, Dunot, Jade, Ribera, Aurore, Temido‐Ferreira, Mariana, Coelho, Joana E., König, Svenja, Moreno, Sébastien, Enguita, Francisco J., Willem, Michael, Kins, Stefan, Marie, Hélène, Lopes, Luísa V., Pousinha, Paula A.
Publicado 2023

Reversine ameliorates hallmarks of cellular senescence in human skeletal myoblasts via reactivation of autophagy

por Rajabian, Nika, Choudhury, Debanik, Ikhapoh, Izuagie, Saha, Shilpashree, Kalyankar, Aishwarya S., Mehrotra, Pihu, Shahini, Aref, Breed, Kendall, Andreadis, Stelios T.
Publicado 2023

Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms

por Traa, Annika, Soo, Sonja K., AlOkda, Abdelrahman, Ko, Bokang, Rocheleau, Christian E., Van Raamsdonk, Jeremy M.
Publicado 2023

Proof‐of‐concept for incorporating mechanistic insights from multi‐omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae

por Hanafin, Patrick O., Abdul Rahim, Nusaibah, Sharma, Rajnikant, Cess, Colin G., Finley, Stacey D., Bergen, Phillip J., Velkov, Tony, Li, Jian, Rao, Gauri G.
Publicado 2023

The variant senescence‐associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia‐inducible factor‐1α

por Wu, Selwin K., Ariffin, Juliana, Tay, Shu Chian, Picone, Remigio
Publicado 2023

Age‐related deficits in neuronal physiology and cognitive function are recapitulated in young mice overexpressing the L‐type calcium channel, Ca(V)1.3

por Moore, Shannon J., Cazares, Victor A., Temme, Stephanie J., Murphy, Geoffrey G.
Publicado 2023

Green serum—A sign of paraquat poisoning

por Maezawa, Toshinori, Tsutsui, Toru
Publicado 2023

Warning about use of pesticides containing inpyrfluxam for suicide

por Irie, Yasuhito, Nakae, Hajime
Publicado 2023

Successfully treated case of severe hypothermia secondary to myxedema coma

por Yamamoto, Hirotsugu, Hongo, Takashi, Nojima, Tsuyoshi, Obara, Takafumi, Kosaki, Yoshinori, Ageta, Kohei, Tsukahara, Kohei, Yumoto, Tetsuya, Nakao, Atsunori, Naito, Hiromichi
Publicado 2023

Demand–supply balance of disaster medical care in Osaka City based on damage estimation for a Nankai Trough megathrust earthquake: A geographic information system‐based analysis...

por Yamamoto, Hiromasa, Kimura, Yoshinari, Uchida, Kenichiro, Nishimura, Tetsuro, Mizobata, Yasumitsu
Publicado 2023

Usefulness of resuscitative endovascular balloon occlusion of the aorta compared to aortic cross‐clamping in severely injured trauma patients: Analysis from the Japan Trauma Data B...

por Haruta, Koichi, Endo, Akira, Shiraishi, Atsushi, Otomo, Yasuhiro
Publicado 2023