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  1. 1269021
    “…All were present in the heterozygous state. Previously reported heterozygous variants were also found in the PROK2 (c.163del, p.Ile55*), CHD7 (c.c.2750C>T, p.Thr917Met and c.7891C>T, p.Arg2631*), FLRT3 (c.1106C>T, p.Ala369Val), and CCDC103 (c.461A>C, p.His154Pro) genes. …”
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    Genetic Analysis of Patients with Congenital Hypogonadotropic Hypogonadism: A Case Series
  2. 1269022
    “…ABSTRACT: As a vector of wide range of pathogenic agents, ticks pose health threats to wild and domestic animals, and humans. …”
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    First Report of Rickettsia conorii in Hyalomma kumari Ticks
  3. 1269023
    “…BACKGROUND: The leaves of Zizyphus spina-christi (L.) Willd contain several compounds exhibiting different pharmacologic activities. …”
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    Isolation and identification of novel selective antitumor constituents, sidrin and sidroside, from Zizyphus spina-christi
  4. 1269024
    “…IMPORTANCE: A correlation between antibody levels and risk of infection has been demonstrated for the wild-type, Alpha, and Delta SARS-COV-2 variants. …”
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    Factors Associated With Protection From SARS-CoV-2 Omicron Variant Infection and Disease Among Vaccinated Health Care Workers in Israel
  5. 1269025
    “…During the warm season, their activity peaks were in the morning and afternoon, and their activity levels were substantially lower after sunrise than they were before sunset. (3) The plateau pikas were more active under conditions with lower ambient temperatures and precipitation during the cold and warm seasons. While relative air humidity was positively correlated with the activity of the plateau pikas during the warm season, wind speed was negatively correlated with the pikas’ activity during the cold season. …”
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    Daily and Seasonal Activity Patterns of Plateau Pikas (Ochotona curzoniae) on the Qinghai–Tibet Plateau, China, and Their Relationship with Weather Condition
  6. 1269026
    “…The average number (mean ± SD) of MB(B7-H3) binding to MS1(B7-H3) cells was estimated to be 354.4 ± 52.3 per field of view (FOV) compared to wild-type control cells (MS1(WT); 36.2 ± 7.5/FOV). …”
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    Synthesis and Evaluation of Clinically Translatable Targeted Microbubbles Using a Microfluidic Device for In Vivo Ultrasound Molecular Imaging
  7. 1269027
    “…In E318K(–) cases MC1R R and r alleles increased melanoma risk relative to wild type (wt), P < 0.001 for both. Similarly, each MC1R RHC genotype (R/R, R/r, R/wt, r/r and r/wt) increased melanoma risk relative to wt/wt (P < 0.001 for all). …”
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    The MC1R r allele does not increase melanoma risk in MITF E318K carriers
  8. 1269028
    “…The measurements show that the fabricated BSFL bins can fulfill the BSF lifecycle requirements. Wild BSFs lay eggs in the medium of BSFL bins, and the hatched larvae decompose it. …”
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    Potential Application of Black Soldier Fly Larva Bins in Treating Food Waste
  9. 1269029
    “…Therapeutic effects were assessed by behavioral tests, histological analysis, and morphological examination after four weeks of intraperitoneal injection with minocycline or vehicle control in Csf1r(+/−) mice and wild-type control littermates. RESULTS: We found that synaptic function was reduced in LTP recordings of neurons in the hippocampal CA1 region, while behavioral tests showed impaired spatial and cognitive memory specifically in male Csf1r(+/−) mice. …”
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    Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)
  10. 1269030
    “…The obtained data were analyzed by Shapiro–Wilks test, Pearson’s correlation coefficient and stepwise linear regression. …”
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    The correlation between strength and range of motion of the neck muscles and opium smoking in Iran
  11. 1269031
    “…We report that these double ORF-deficient rSARS-CoV-2s have slower replication kinetics and reduced fitness in cultured cells compared with their parental wild-type (WT) counterpart. …”
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    Immunization with Recombinant Accessory Protein-Deficient SARS-CoV-2 Protects against Lethal Challenge and Viral Transmission
  12. 1269032
    “…Vaccination during B cell depletion may pave the way for better quality of antibody responses after B cell reconstitution. …”
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    Fourth mRNA COVID-19 vaccination in immunocompromised patients with haematological malignancies (COBRA KAI): a cohort study
  13. 1269033
    “…Early meta-analyses of COVID-19 reported serial intervals of 5.2 days (95% CI: 4.9–5.5) for the original wild-type variant and 5.2 days (95% CI: 4.87–5.47) for Alpha variant. …”
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    Rapid review and meta-analysis of serial intervals for SARS-CoV-2 Delta and Omicron variants
  14. 1269034
    “…KMT2C-mutated patients showed worse survival than KMT2C-wild type (WT) patients regarding both CRFS and OS (CRFS: mutated: 9.9 vs. …”
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    Mutations in epigenetic regulator KMT2C detected by liquid biopsy are associated with worse survival in prostate cancer patients
  15. 1269035
    “…China has been breeding forest musk deer artificially since the 1950s in an effort to restore wild populations, with Shaanxi and Sichuan provinces as the two main sites for captive breeding. …”
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    mtDNA CR Evidence Indicates High Genetic Diversity of Captive Forest Musk Deer in Shaanxi Province, China
  16. 1269036
    “…BACKGROUND: interleukin 23 (IL-23) is an important factor involved in the survival and proliferation of T helper 17 cells (Th17), known for their implication in multiple sclerosis (MS). …”
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    Interleukins (IL-23 and IL-27) serum levels: Relationships with gene polymorphisms and disease patterns in multiple sclerosis patients under treatment with interferon and glatiramer acetate
  17. 1269037
    “…Virulence genes, such as agg, fsrA, fsrB, fsrC, gelE, sprE, pil, and ace, were harbored in enterococci isolates. …”
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    Antimicrobial Resistance Profiles, Virulence Determinants, and Biofilm Formation in Enterococci Isolated from Rhesus Macaques (Macaca mulatta): A Potential Threat for Wildlife in Bangladesh?
  18. 1269038
    “…On the cellular level, the defective functioning of mitochondria—the powerplants of the cells—is one of several hallmarks of RTT. Mitochondria contain more than 1000 different proteins, and their composition differs among tissues. …”
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    Mitochondrial Proteome Changes in Rett Syndrome
  19. 1269039
    “…Compared with the TP53mut subtype, the POLE EDM, MSI-H and TP53 wild-type subtypes were defined as non-TP53mut subtypes. …”
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    A nomogram prediction model for the TP53mut subtype in endometrial cancer based on preoperative noninvasive parameters
  20. 1269040
    “…Consequently, Tregs from p53(f/f)/CD4-Cre(+) CLP mice exhibited limited suppressive ability, as indicated by the reduced production of transforming growth factor-β and interleukin 10 (IL-10). In the coculture system, Teffs showed preserved production of IL-2, differentiation into Th1 cells and proliferation in the presence of Tregs isolated from p53(f/f)/CD4-Cre(+) CLP mice. …”
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    p53 promotes the expansion of regulatory T cells via DNMT3a- and TET2- mediated Foxp3 expression in sepsis
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