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  1. 1269181
    “…We investigated the effect of the Tyr161Cys, Ser171Asn and Gly553Arg mutations on receptor dimerization using western blotting and showed that these mutant proteins all form dimers similar to the wild-type (WT) CaSR. …”
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    SAT-036 Extracellular Domain Calcium-Sensing Receptor (CaSR) Mutations Leading to Hypercalcemic and Hypocalcemic Disorders Cluster at the Homodimeric Interface
  2. 1269182
    “…Though ghrelin is predominantly produced by stomach X/A cells, it is also made in the pancreas. Within the pancreatic islet, ghrelin is produced by ε-cells and GHSR is predominantly expressed in somatostatin-secreting δ-cells. …”
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    SAT-167 Intra-Islet Ghrelin Signaling Does Not Regulate Insulin Secretion from Adult Mice
  3. 1269183
    “…To study the effect of the mutation on this interaction, CCDC53 was first ablated in HEK293 cells (CCDC53KO-HEK) by CRISPER-Cas9 and then wild-type (WT) or mutant (mut) CCDC53 or empty vector (EV) was expressed in these cells. …”
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    SAT-283 A Mutation In Ccdc53 Affects Pth1r Trafficking And Causes Disproportionate Short Stature With Noonan-like Facies
  4. 1269184
    “…A number of aberrant gene expressions have been demonstrated in endometriosis, and these aberrations may be related to epigenetic aberrations. Our Genome-wide DNA methylation analysis showed a GATA6 gene body highly hypomethylated in endometrial cells. …”
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    SAT-199 A Hypomethylated GATA6 Gene Body May Function as an Active Enhancer in Endometriotic Cells
  5. 1269185
    “…One salient finding was a significantly smaller pool of PAX7-positive satellite cells (SCs) in the skeletal muscle of TRα1PV mice. …”
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    SAT-560 Role of COUP-TFII and Thyroid Hormone Receptor α in Skeletal Muscle Loss
  6. 1269186
    por Park, Sunmi, Cheng, Sheue-Yann
    Publicado 2019
    “…Analysis of the expression data showed an enrichment of genes that were associated with immune cell markers, cytokines, and chemokines, including Ptgs1, Sphk1, OPN, Tnfrsf18, CCL12, and IL6. …”
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    SUN-338 Inflammation Promotes Aggressive Thyroid Cancer Progression in a Mouse Model
  7. 1269187
    “…TRH-DE activity was reduced in heterozygote (HT) and eliminated in homozygote (KO) compared to wild type (WT) animals. Male mice (70-75 days old) were switched from a standard diet to a high fat high fructose diet (HFFD) for 9 weeks. …”
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    SUN-465 Thyrotropin-Releasing Hormone-Degrading Ectoenzyme Controls Thyrotropin Secretion and Body Weight in Male Rodents
  8. 1269188
    “…They were also resistant to the suppression of the pro-inflammatory gene of IL-6 and induction of GC response gene GILZ, a mediator of anti-inflammatory effects. …”
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    OR09-3 11β-HSD1 Mediates a Partial Suppression of Muscle Atrophy in Chronic Inflammatory Disease in Response to Therapeutic Glucocorticoids
  9. 1269189
    “…We therefore studied the progeny of wild-type (WT) adults (second and third generations), descendent of grandmothers and great grandmothers with high TH levels but euthyroid due to THRB gene mutations, who gave birth to the first WT generation exposed to high TH levels during fetal life. …”
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    OR10-5 Reduced Sensitivity to Thyroid Hormone Due to Fetal Exposure to High Thyroid Hormone Levels Is Transmitted along Male Line to Two Subsequent Generations
  10. 1269190
    “…Gilz promoter methylation was reduced in preterm offspring with a negative correlation between methylation and expression (P=0.008), highly suggestive of an epigenetic Gilz regulation. …”
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    OR07-4 Preterm Birth and Transgenerational Epigenetic Programming of Hypertension in Mice
  11. 1269191
    “…Methods: We investigated a family with novel co-occurrence of all four SDH-related tumors: PGL in two siblings; GIST in a third sibling; PA in the fourth sibling; and RCC in their deceased mother. …”
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    OR34-6 A Novel Mechanism of SDH-Deficient Tumorigenesis and Implications for Genetic Testing in Patients with Pheochromocytoma-Paraganglioma
  12. 1269192
    “…The molecular physiopathogenesis of the novel Ile423Thr mutation was analyzed by a series of in silico and in vitro biochemical studies in HEK293 cells transiently expressing either the wild-type (Wt) FSHR or the Ile423Thr mutant cloned into the pSG5 vector, and the results were compared with those obtained in cells transfected with the expression-deficient Asp408Tyr mutant, which leads to a more severe form of hypergonadotropic hypogonadism (1). …”
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    OR08-4 A Novel Mutation in the Follicle-Stimulating Hormone Receptor (Ile423Thr) in a Woman with Normal Pubertal Development and Primary Amenorrhea: In Vivo, In Vitro, and In Silico Studies
  13. 1269193
    “…RESULTS: The age of the patients ranged from 46 to 69 years. All cases were in stage II and treated with surgery. …”
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    Clinicopathological characteristics and molecular abnormalities of primary grade 2 neuroendocrine tumors of the cervix
  14. 1269194
    “…Eighty percent (80%) mortality was recorded in wild population of An. gambiae s.l. exposed to unused PermaNet(®) 3.0, but its bioactivity subsequently declined as washing frequency increased from 0 to 20. …”
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    Bio-efficacy and physical integrity of piperonylbutoxide coated combination net (PermaNet(®) 3.0) against pyrethroid resistant population of Anopheles gambiae s.l. and Culex quinquefasciatus mosquitoes in Ethiopia
  15. 1269195
    “…METHODS: Cell proliferation, cell apoptosis and cell cycle arrest assays were performed to examine the effects of PEITC on prostate cancer cell lines with p53 mutation(s), wild-type p53, p53 null or normal prostate cells in vitro. …”
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    p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition
  16. 1269196
    “…While most MS therapeutics target adaptive immunity, we recently reported that reducing TLR2 signaling in innate immune cells by inducing TLR2 tolerance attenuates adoptively transferred experimental autoimmune encephalomyelitis. …”
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    Systemic TLR2 tolerance enhances central nervous system remyelination
  17. 1269197
    “…Individual fisherman, with their own best interest in mind, used to wish to increase their individual landings and create an incentive to ask to increase the TAC for the industry, without realizing the possible revenue loss due to the resulting falling prices. …”
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    More landings for higher profit? Inverse demand analysis of the bluefin tuna auction price in Japan and economic incentives in global bluefin tuna fisheries management
  18. 1269198
    “…RESULTS: The LNA-RT-PCR could discriminate rtM204I mutant-type (17 patients, 4.2%) from rtM204 wild-type (386 patients, 95.8%) in 403 of 410 patients (98.3% sensitivity). …”
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    Tenofovir is a more suitable treatment than entecavir for chronic hepatitis B patients carrying naturally occurring rtM204I mutations
  19. 1269199
    “…This study aimed to further explore the mutation mechanisms that lead to podocyte injury. METHODS: Wild-type (WT) and four mutant COL4A3 segments were constructed into a lentiviral plasmid, then stably transfected into human podocytes. …”
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    Endoplasmic reticulum stress and proteasome pathway involvement in human podocyte injury with a truncated COL4A3 mutation
  20. 1269200
    “…METHODS: CCR5 targeted combination antiretroviral drugs (cARV) loaded nanoparticles (NPs) were synthesized based on water-in-oil-in-water (W-O-W) emulsion methodology. For targeting CCR5+ T cells, a modified high affinity CCR5 monoclonal Ab (XFCCR5 mAb), was isolated from XF-CCR5 hybridoma cells. …”
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    2501. CCR5 Targeted ARV Loaded Nanoparticle: Dual Protection for HIV Functional Cure
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