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  1. 1269521
    “…IMPORTANCE Restoring damaged microbiomes is still a formidable challenge. Classical widely adopted approaches consist of augmenting communities with pure or mixed cultures in the hope that these display their intended selected properties under in situ conditions. …”
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    Fitness-Conditional Genes for Soil Adaptation in the Bioaugmentation Agent Pseudomonas veronii 1YdBTEX2
  2. 1269522
    “…Here we use inducible CRISPR-Cas9 systems to develop two GEMMs which aim to model the extensive chromosome p3 deletion frequently observed in clear cell renal cell carcinoma (ccRCC). We cloned paired guide RNAs targeting early exons of Bap1, Pbrm1, and Setd2 in a construct containing a Cas9(D10A) (nickase, hSpCsn1n) driven by tetracycline (tet)-responsive elements (TRE3G) to develop our first GEMM. …”
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    Novel genetically engineered mouse models for clear cell renal cell carcinoma
  3. 1269523
    “…The recent publication of a new chromosome-level reference genome for QX1410, a C. briggsae wild strain closely related to AF16, has provided the first step to bridge the gap between C. elegans and C. briggsae genome resources. …”
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    Novel and improved Caenorhabditis briggsae gene models generated by community curation
  4. 1269524
    “…Moreover, humoral and adaptive immunological conditions were shown to be in harmony after rAdv-ChGM-CSF-HN inoculation and uniformly enhanced the expression of alpha interferon (IFN-α), IFN-β, IFN-γ, interleukin-1β (IL-1β), IL-2, IL-16, IL-18, and IL-22. Postchallenge, the control challenge (CC), wild-type adenovirus (wtAdv), and rAdv-ChGM-CSF groups developed unique NDV clinical manifestations, significant viral shedding, high tissue viral loads, gross and microscopic lesions, and 100% mortality within 7 days. …”
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    Simultaneous Expression of Chicken Granulocyte Monocyte Colony-Stimulating Factor and the Hemagglutinin-Neuraminidase Epitope of the Virulent Newcastle Disease Virus Genotype VII C22 Strain in a Functional Synthetic Recombinant Adenovirus as a Genotype-Matched Vaccine with Potential Antiviral Activity
  5. 1269525
    “…The most profound changes consist of the formation of two types of protein aggregations, called β-amyloid plaques and neurofibrillary tangles of tau proteins. …”
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    Alzheimer’s Disease and Age-Related Changes in the Cu Isotopic Composition of Blood Plasma and Brain Tissues of the APP(NL-G-F) Murine Model Revealed by Multi-Collector ICP-Mass Spectrometry
  6. 1269526
    “…Normality testing using Shapiro-Wilk test statistic revealed non-Gaussian distribution of data, hence, were presented as median, minimum, and maximum. …”
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    Variations in the full blood count parameters among apparently healthy humans in the Ho municipality using ethylenediamine tetraacetic acid (EDTA), sodium citrate and lithium heparin anticoagulants: A laboratory-based cross-sectional analytical study
  7. 1269527
    “…In the spleen and ILN of C57BL6-cd40l(−) (/−) mice IgA-producing cells significantly decreased, while IgM-positive plasma cells increased. …”
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    Elevated levels of enteric IgA in an unimmunised mouse model of Hyper IgM syndrome derived from gut-associated secondary lymph organs even in the absence of germinal centres
  8. 1269528
    “…HSPB8_fs mutants aggregation alters the differentiation capacity of muscle cells and impairs sarcomere organization. Collectively, these results shed light on a potential pathogenic mechanism shared by the HSPB8_fs mutants described in neuromuscular diseases. …”
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    HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies
  9. 1269529
    “…SETTING: Denmark, Finland, Norway, and Sweden, 27 December 2020 to 31 December 2022. PARTICIPANTS: All adults aged ≥18 years who had received at least a primary vaccination schedule of AZD1222 (Oxford-AstraZeneca) or monovalent SARS-CoV-2 wild type (ancestral) strain based mRNA vaccines BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna), in any combination. …”
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    Comparative effectiveness of heterologous third dose vaccine schedules against severe covid-19 during omicron predominance in Nordic countries: population based cohort analyses
  10. 1269530
    “…In our present study, we evaluated the role of DA in inducing apoptotic cell death in multidrug-resistant colorectal cancer cells. …”
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    Decursinol Angelate Inhibits Glutamate Dehydrogenase 1 Activity and Induces Intrinsic Apoptosis in MDR-CRC Cells
  11. 1269531
    “…Similar results were recorded comparing the groups one week after surgery (PG: 1.2 ± 1.2; CG: 2.1 ± 1.3; p = 0.0005). All patients reported a decrease in facial swelling from T1 to T2 without differences between the two groups. …”
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    Three-dimensional facial swelling evaluation of pre-operative single-dose of prednisone in third molar surgery: a split-mouth randomized controlled trial
  12. 1269532
    “…Polo-Like Kinase 1 (PLK1), a key mediator of cell-cycle progression, is associated with poor prognosis and is a therapeutic target in a number of malignancies. …”
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    PLK1 Regulates MicroRNA Biogenesis through Drosha Phosphorylation
  13. 1269533
    “…When comparing GHR-KO visceral to WT, terms associated with IGF signaling and longevity regulation had decreased expression, while immune activation and cell motility were increased. …”
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    THU051 GH Resistance And Adipose Tissue: Multispecies Measurement Of Morphology And Transcriptome
  14. 1269534
    “…Moreover, in the latter approach ectopic expression of blt2a mRNA effectively restored the wild-type phenotype. To determine if BLT2 mediates macrophage migration to injured islets, we employed a transgenic zebrafish model of β-cell injury, Tg(ins:NTR), in which metronidazole treatment rapidly induces β-cell injury. …”
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    SAT066 Leukotriene B4 Receptor 2 Mediates Macrophage Migration To Injured β Cells
  15. 1269535
    por Young, Demarrius
    Publicado 2023
    “…There are six groups in this study: wild type (WT) no treatment, WT treatment-1, WT treatment-2, LivARKO no treatment, LivARKO treatment-1, and LivARKO treatment-2. …”
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    FRI024 The Effect Of High Fat Diet On Insulin Signaling In White Adipose Tissue Of Liver Androgen Receptor Knockout In Female Mice
  16. 1269536
    “…SIMPLE SUMMARY: The supply of fish oil, which provides long-chain polyunsaturated fatty acids (LC-PUFA) but is mostly wild-caught, is stagnating, resulting in limited availability and high prices. …”
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    Feeding Strategy to Use Beef Tallow and Modify Farmed Tiger Puffer Fatty Acid Composition
  17. 1269537
    “…This study aimed to investigate the initial post-release performance of cultured Cyprinus chilia juveniles by examining their movement, spatial distribution, gut fullness, and gut microbiota in nature. In July 2022, a total of 20,000 C. chilia juveniles, tagged with visible implant fluorescence (VIE), were released into Qilu Lake, a shallow lake in southwestern China. …”
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    Initial Post-Release Performance of Cultured Cyprinus chilia Juveniles in a Shallow Lake in Southwestern China
  18. 1269538
    “…To address these limitations and gain a clearer understanding of the genetic dynamics, we employed DArT sequencing to identify genome-wide single nucleotide polymorphisms (SNPs) in both species and confirm hybrid scenarios. …”
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    Preserving Pure Siamese Crocodile Populations: A Comprehensive Approach Using Multi-Genetic Tools
  19. 1269539
    “…The results showed that the AUC value of the test set was 0.955. The true skill statistic (TSS) value is 0.5924, indicating that the model had good prediction accuracy. …”
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    An Evaluation of Suitable Habitats for Amur Tigers (Panthera tigris altaica) in Northeastern China Based on the Random Forest Model
  20. 1269540
    “…BACKGROUND: As wild poliovirus is eradicated, preventing circulation of vaccine-derived poliovirus is top priority. …”
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    1744. Next generation sequencing (NGS) optimization of Oral Polio Vaccine samples
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