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  1. 1269561
    por Wei, Qinghui, Zhao, Min, Li, Xiaoyan
    Publicado 2017
    “…BACKGROUND: Chemical fungicides are widely used to control crop diseases, but these chemicals have adverse effects. …”
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    Extraction of Chelerythrine and its Effects on Pathogenic Fungus Spore Germination
  2. 1269562
    “…Moreover, the glomerular expressions of TGF-β1, CTGF and VEGF-A proteins were 2.7, 2.2 and 3.8-fold higher in mice exposed to IH (p< 0.05 for all). Furthermore, western blotting protein analysis demonstrates that IH-exposed mice express higher levels of TGF-β1, CTGF and VEGF-A proteins by 1.9, 4.0 and 1.6-fold (p< 0.05 for all) respectively. …”
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    Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea
  3. 1269563
    “…These studies raise the possibility that disrupted signaling of mGlu1 and/or mGlu3 could contribute to the symptoms of schizophrenia and that selective modulators of these receptors could provide a novel approach to treatment of this disorder. METHODS: Wild-type and mutant forms of mGlu receptors were expressed in cell lines and used for discovery and optimization of highly selective positive allosteric modulators (PAMs) of mGlu1 and mGlu3. …”
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    43.1 GENETIC INSIGHTS LEAD TO DISCOVERY OF SELECTIVE ACTIVATORS OF MGLU1 AND MGLU3 METABOTROPIC GLUTAMATE RECEPTORS AS POTENTIAL TREATMENTS FOR SCHIZOPHRENIA
  4. 1269564
    “…OBJECTIVE: To characterize the hRPTC ion transport of wild-type (WT) and homozygous variants (HV) of SLC4A5. …”
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    Sodium bicarbonate cotransporter NBCe2 gene variants increase sodium and bicarbonate transport in human renal proximal tubule cells
  5. 1269565
    por Zhou, Cheng, Xue, Yanfen, Ma, Yanhe
    Publicado 2018
    “…Alkaline and thermostable β-mannanases provide obvious advantages for many applications in biobleaching of pulp and paper, detergent industry, oil grilling operation and enzymatic production of mannooligosaccharides. …”
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    Characterization and high-efficiency secreted expression in Bacillus subtilis of a thermo-alkaline β-mannanase from an alkaliphilic Bacillus clausii strain S10
  6. 1269566
    “…FINDINGS: In QUASAR 2 (511 tumours), TP53, KRAS, BRAF, and GNAS mutations were independently associated with shorter relapse-free survival (p<0·035 in all cases), and total somatic mutation burden with longer survival (hazard ratio [HR] 0·81 [95% CI 0·68–0·96]; p=0·014). …”
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    Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series
  7. 1269567
    “…Similarly, alloantibody responses generated in Tcrbd(−/−) recipients reconstituted with smaller number of wild-type TCR75 CD4 T cells (10(3)), although long-lasting, did not have a discernible extrafollicular component, and grafts were rejected much more slowly (MST 50 days). …”
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    Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection
  8. 1269568
    “…These GIPR agonists lowered acute blood glucose in wild-type and Glp1r−/− mice, and this effect was absent in Gipr−/− mice, which confirmed selectivity towards GIPR. …”
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    Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
  9. 1269569
    “…Ten recombinant VHSVs (rVHSVs) were generated, including two parental rVHSVs, by transfecting fish cells with ten individual full-length plasmid constructs along with supporting plasmids using the established protocol. …”
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    The glycoprotein, non-virion protein, and polymerase of viral hemorrhagic septicemia virus are not determinants of host-specific virulence in rainbow trout
  10. 1269570
    por Stoykovich, Seth, Gibas, Kelly
    Publicado 2019
    “…The patient's baseline Montreal Cognitive Assessment improved from 23/30 (mild AD) to 29/30 (normal ≥ 26). His T2DM was reversed. …”
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    APOE ε4, the door to insulin-resistant dyslipidemia and brain fog? A case study
  11. 1269571
    “…Here we investigated the HNF4α role in the IR-induced β-cell proliferation. We used WildType (C) and Knockout (K) animals for HNF4-alpha (HNF4α(loxP/loxP;Ins.Cre)). …”
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    SAT-162 Hepatocyte Nuclear Factor-4α (HNF44α) as a Target to Treat DM
  12. 1269572
    “…Besides mild tachycardia (heart rate: 98 beats per minute), she had no other symptoms and signs of hyperthyroidism. …”
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    SAT-616 Coexistence of Resistance to Thyroid Hormone Syndrome and Pituitary Granular Cell Tumor in a Taiwanese Young Lady Mimicking TSH Secreting Tumor
  13. 1269573
    “…In the zebrafish model, satb1 knockout led to significantly smaller size at 3 wpf, compared with heterozygous and wild type controls (median standard length: 6.6, 7.4, and 7.8 cm, and mean weight: 2.7, 4.3, and 4.6 mg, respectively, P<0.05 for all comparisons). …”
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    SUN-038 Role Of The Satb 1 Gene In Growth Across Species: Findings In A Cohort Of Patients With Short Stature And In A Knockout Zebrafish Model
  14. 1269574
    “…The fathers of the two girls with Ile461Phe and Met126Val mutations without a known family history of CPP were sequenced and harbored the corresponding mutations. …”
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    SUN-264 Mutations in the Maternally Imprinted Genes, MKRN3 and DLK1, Associated with Central Precocious Puberty
  15. 1269575
    “…Next, a mouse model of hyperthyroidism, generated by administrating T3 in drinking water, led to a significant 10% increase in renal 11βHSD2 mRNA and protein levels compared to wild type mice (n=10, p<0.05). Furthermore, we demonstrated in HEK293T cells that T3 transactivates the mouse hsd11b2 promoter cloned upstream the luciferase reporter gene via the Thyroid Receptor α1(TRα1). …”
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    OR10-1 Regulation of Glucocorticoid Metabolism: A Novel Function for Thyroid Hormones?
  16. 1269576
    por Cochran, Jesse
    Publicado 2019
    “…After 15 weeks of feeding, females on KD displayed an increase in body weight (1.07-fold KD vs. CD, p<0.05) while body weight declined in males (0.88-fold, p<0.05). …”
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    OR12-5 Sex Differences in the Response of C57bl/6 Mice To Ketogenic Diets
  17. 1269577
    “…Though metabolic studies using full body MR(-/-) mice are impractical since these mice die within 10 days of birth due to salt wasting, we do show that MR(-/-) mice have white and brown adipose depots that are similar to wild-type littermates at 5 postnatal. …”
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    OR28-1 Role of Mineralocorticoid Receptor in Metabolic Syndrome
  18. 1269578
    “…The GLP-1 receptor (GLP-1R) is a G-protein coupled receptor that is expressed widely, encoded for by GLP1R. The GLP1R variant rs6923761 (Gly168Ser) has been associated with increased weight loss in response to GLP-1 agonist therapy in some studies. …”
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    OR05-6 The Effect of the GLP1R Variant rs6923761 on Post-Prandial Glucose Levels during Treatment with Sitagliptin
  19. 1269579
    “…Tumor-suppressor p53 protein was shown to be a novel translationally-regulated target of CPEB2, validated with polysome profiling. CPEB2KO, but not wild-type cells produced lung colonies upon intravenous injection and subcutaneous tumors and spontaneous lung metastases upon implantation at mammary sites in NOD/SCID/IL2Rϒ-null mice, identified with HLA immunostaining. …”
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    Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells
  20. 1269580
    “…The effect of αvβ3 integrin expression and activity on GULP1 mRNA levels was measured using qPCR in TM-1 cells overexpressing wild type or constitutively active αvβ3 integrin. …”
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    Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis
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