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1269741por Channon-Wells, Samuel, Vito, Ortensia, McArdle, Andrew J, Seaby, Eleanor G, Patel, Harsita, Shah, Priyen, Pazukhina, Ekaterina, Wilson, Clare, Broderick, Claire, D'Souza, Giselle, Keren, Ilana, Nijman, Ruud G, Tremoulet, Adriana, Munblit, Daniel, Ulloa-Gutierrez, Rolando, Carter, Michael J, Ramnarayan, Padmanabhan, De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A, Kaforou, Myrsini, Cunnington, Aubrey J, Blyuss, Oleg, Levin, Michael“…BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. …”
Publicado 2023
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1269742por Lee, Da Som, An, Tae Hyeon, Kim, Hyunmi, Jung, Eunsun, Kim, Gyeonghun, Oh, Seung Yeon, Kim, Jun Seok, Chun, Hye Jin, Jung, Jaeeun, Lee, Eun-Woo, Han, Baek-Soo, Han, Dai Hoon, Lee, Yong-Ho, Han, Tae-Su, Hur, Keun, Lee, Chul-Ho, Kim, Dae-Soo, Kim, Won Kon, Park, Jun Won, Koo, Seung-Hoi, Seong, Je Kyung, Lee, Sang Chul, Kim, Hail, Bae, Kwang-Hee, Oh, Kyoung-Jin“…Indeed, hepatic Tcf7l2 deficiency enhanced liver lipid content in a manner that was dependent on the duration and amount of exposure to carbohydrates, owing to cell-autonomous increases in hepatic DNL. Mechanistically, TCF7L2 regulated the transcriptional activity of Mlxipl (also known as ChREBP) by modulating O-GlcNAcylation and protein content of carbohydrate response element binding protein (ChREBP), and targeted Srebf1 (also called SREBP1) via miRNA (miR)-33-5p in hepatocytes. …”
Publicado 2023
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1269743por He, Zhi-quan, Hu, Ya-bo, Wang, Dan, Liu, Yu-ting, Yang, Cheng-yun, Qian, Dan, Zhou, Rui-min, Lu, De-ling, Li, Su-hua, Liu, Ying, Zhang, Hong-wei“…The genotypes with the highest frequency in the populations of An. sinensis in Xiangfu and Tanghe were the mutant TTT (F/F) and wild-type TTG (L/L), at 67.86% (57/84) and 74.29% (52/70), respectively. …”
Publicado 2023
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1269744“…This could help hospitals to maintain their data privacy, while using a federated trained classifier with nearly similar performance as that from a centrally trained one. …”
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1269745por Zhou, Jie, Singanayagam, Anika, Goonawardane, Niluka, Moshe, Maya, Sweeney, Fiachra P, Sukhova, Ksenia, Killingley, Ben, Kalinova, Mariya, Mann, Alex J, Catchpole, Andrew P, Barer, Michael R, Ferguson, Neil M, Chiu, Christopher, Barclay, Wendy S“…Participants were inoculated with 10 50% tissue culture infectious dose of pre-alpha wild-type SARS-CoV-2 (Asp614Gly) by intranasal drops and remained in individual negative pressure rooms for a minimum of 14 days. …”
Publicado 2023
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1269746por Noorani, Imran, Sidlauskas, Kastytis, Pellow, Sean, Savage, Reece, Norman, Jeannette L, Chatelet, David S, Fabian, Mark, Grundy, Paul, Ching, Jeng, Nicoll, James A R, Boche, Delphine“…In this study, we performed a quantitative immunohistochemical analysis of 15 markers of microglia/macrophage phenotypes (including anti-inflammatory markers triggering receptor expressed on myeloid cells 2 and CD163, and the low-affinity-activating receptor CD32a), T cells, natural killer cells and programmed death-ligand 1, in 59 human IDH1-wild-type glioblastoma multi-regional samples (n = 177; 1 sample at tumour core, 2 samples at the margins: the infiltrating zone and leading edge). …”
Publicado 2023
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1269747por Islam, Ariful, Amin, Emama, Islam, Shariful, Hossain, Mohammad Enayet, Al Mamun, Abdullah, Sahabuddin, Md., Samad, Mohammed Abdus, Shirin, Tahmina, Rahman, Mohammed Ziaur, Hassan, Mohammad Mahmudul“…The impacts of the avian influenza virus (AIV) on farmed poultry and wild birds affect human health, livelihoods, food security, and international trade. …”
Publicado 2023
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1269748“…BACKGROUND: The Annexin A6 (AnxA6) protein is known to inhibit the epidermal growth factor receptor (EGFR)-extracellular signal regulated kinase (ERK)1/2 signaling upon EGF stimulation. While the biochemical mechanism of AnxA6 inactivating phosphorylation of EGFR and ERK1/2 is not completely explored in cancer cells. …”
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1269749por Avila, Amanda, Triana, Jairo, buldo-licciardi, michael, Li, Zachary, Campbell, Kirk, Jazrawi, Laith, Alaia, Michael, Furgiuele, David, Popovic, Jovan, Strauss, Eric, Rao, Naina“…RESULTS: A total of 20 patients were preliminarily analyzed with all patients having at least 1 week of post-operative follow-up. …”
Publicado 2023
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1269750por Raun, Steffen H., Ali, Mona S., Han, Xiuqing, Henríquez‐Olguín, Carlos, Pham, T.C. Phung, Meneses‐Valdés, Roberto, Knudsen, Jonas R., Willemsen, Anna C.H., Larsen, Steen, Jensen, Thomas E., Langen, Ramon, Sylow, Lykke“…To determine the role of muscle AMPK, male mice overexpressing a dominant‐negative AMPKα2 (kinase‐dead [KiDe]) specifically in striated muscle were inoculated with Lewis lung carcinoma (LLC) cells (wild type [WT]: n = 27, WT + LLC: n = 34, mAMPK‐KiDe: n = 23, mAMPK‐KiDe + LLC: n = 38). …”
Publicado 2023
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1269751por Ehrlich, Margot, Madden, Christopher, McBride, Dillon S., Nolting, Jacqueline M., Huey, Devra, Kenney, Scott, Wang, Qiuhong, Saif, Linda J., Vlasova, Anastasia, Dennis, Patricia, Lombardi, Dusty, Gibson, Stormy, McLaine, Alexis, Lauterbach, Sarah, Yaxley, Page, Winston, Jenessa A., Diaz-Campos, Dubraska, Pesapane, Risa, Flint, Mark, Flint, Jaylene, Junge, Randy, Faith, Seth A., Bowman, Andrew S., Hale, Vanessa L.“…In this study, we tested 792 domestic and wild animals around Ohio between May 2020 and August 2021. …”
Publicado 2023
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1269752por Esparza, Thomas J., Su, Shiran, Francescutti, Caroline M., Rodionova, Elvira, Kim, Joong Hee, Brody, David L.“…The histidine mutant nanobodies were coupled to neurotensin for in vivo functional blood brain barrier transcytosis testing via central neurotensin-mediated hypothermia in wild-type mice. Multi-nanobody constructs including the mutant M1(R56H, P96H, Y102H) and two copies of the P2X7 receptor-binding 13A7 nanobody were produced to test proof-of-concept macromolecular cargo transport in vivo using quantitatively verified capillary depleted brain lysates and in situ histology. …”
Publicado 2023
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1269753por Butz, Henriett, Nagy, Petra, Papp, János, Bozsik, Anikó, Grolmusz, Vince Kornél, Pócza, Tímea, Oláh, Edit, Patócs, Attila“…We did not find a significant difference in the incidence of PALB2 disease-causing variants according to age; however, the median age of tumor onset was lower in PALB2 P/LP carriers versus wild-type patients (44 vs. 48 years). In our cohort, the odds ratio for breast cancer risk in women with PALB2 P/LP variants was between 8.1 and 9.3 compared to non-HBOC cancer patients and the non-cancer population, respectively. …”
Publicado 2023
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1269754por Dimopoulou, Irene, Anagnostou, Tilemachos, Savvas, Ioannis, Karamichali, Panagiota, Prassinos, Nikitas“…For data analysis, the Shapiro–Wilk test of normality, chi-square, Student t test and Split Plot analysis were used. …”
Publicado 2023
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1269755por Zhu, Jiafeng, Li, Qian, Sun, Yan, Zhang, Shiyu, Pan, Ruiyan, Xie, Yanguang, Chen, Jinyan, Shi, Lihong, Chen, Yanbo, Sun, Zhipeng, Zhang, Lane“…METHODS AND RESULTS: Using primary mouse cardiac microvascular endothelial cells and fibroblasts, in vitro experiments were performed. …”
Publicado 2023
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1269756por Lizneva, Daria, Gumerova, Anisa, Ievleva, Kseniia, Barak, Orly, Korkmaz, Funda, Roig, Judit Gimenez, Frolinger, Tal, Pevnev, Georgii, Sultana, Farhath, Kramskiy, Natan, Wizman, Soleil, Orloff, Michelle, Pallapati, Anusha Rani, Rojekar, Satish, Ryu, Vitaly, Moldavski, Ofer, Yuen, Tony, Zaidi, Mone“…Intraperitoneal AlexaFluor-488–labeled hCG bound to gonadal and subcutaneous fat pads in wild type mice, but not in Lhcgr(-/-) mice. Following i.v. (89)Zr–LH injection, radioactivity was detected in mesenteric, inguinal and gonadal WAT. …”
Publicado 2023
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1269757por Tinano, Flavia Rezende, Pereira, Sidney Alcântara, Boris, Natalia P, Macedo, Delanie B, Machado Canton, Ana Pinheiro, Abreu, Ana Paula, Carroll, Rona Stephanie, Latronico, Ana Claudia, Kaiser, Ursula B“…In contrast, Dlk1 expression was higher at P60 compared to P22 in the MBH of male mice, while in female mice it was higher at P22 and P30 compared to P10. …”
Publicado 2023
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1269758por Chauhan, Gaurav, Venkadakrishnan, Varadha Balaji, Dahiya, Ujjwal, Ghanem, Yara, Srinivasan, Gideon Jebaraj, Willard, Belinda, Hu, Qiang, Cortes, Eduardo, Liu, Song, Heemers, Hannelore“…Co-IP assays confirmed that both SRF and PKN1 interacted with UPF1 and showed wild-type PKN1 increased while kinase-dead PKN1 decreased UPF1-SRF interactions. …”
Publicado 2023
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1269759por Shankar, Kripa, Varshney, Salil, Gupta, Deepali, Singh, Omprakash, Ogden, Sean B, Osborne-Lawrence, Sherri, Metzger, Nathan P, Richard, Corine P, Marc Zigman, Jeffrey“…Methods: Eight-ten week-old male wild-type (WT), Ghrelin-KO, LEAP2-KO, and LEAP2/Ghrelin-doubleKO (lacking both ghrelin and LEAP2 ) littermates were used for this study (n=7-10 per genotype). …”
Publicado 2023
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1269760“…In addition, the ovaries of miR-93+ mice had reduced expression of Cdkn1a, similar to that observed in granulosa cells from PCOS patients. miR-93+ mice gained more weight and epididymal AT than controls. miR-93+ mice also demonstrated a lesser response to insulin during an insulin tolerance test (ITT) and exhibited altered estrous cycles as compared to wild type. …”
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