“…There is growing interest in the control of these vectors using the sterile insect technique in which large numbers of sterilized males are released and compete with wild fertile males for mates. Females that mate with sterile males do not produce viable offspring. …”
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“…AIMS/HYPOTHESIS: Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in disease development, none has explored the role of C2CD4B. …”
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“…Methods: Three week-old miR-21 knockout (miR21KO) or wild type (WT) female mice were treated with dihydrotestosterone (DHT, 8 mg/silastic tube) or vehicle for 90 days (n=12/grp). …”
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“…In this study, we examined the impact of two different multifraction X-ray radiation exposure (MFR) regimens, fraction dose escalation (FDE) in the split course and the conventional hypofractionation (HF), on the phenotypic and molecular signatures of four MFR-surviving NSCLC cell sublines derived from parental A549 (p53 wild-type) and H1299 (p53-null) cells, namely A549FR/A549HR, H1299FR/H1299HR cells. …”
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“…It also inhibited tumor growth in vivo compared to controls, which confirmed the significant difference in growth in vitro between HBp17-KO cells and wild-type (WT) cells, indicating that HBp17/FGFBP-1 is a potent therapeutic target in squamous cell carcinomas (SCC) and oral squamous cell carcinomas (OSCC). …”
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“…Prediction error response was elevated in participants with anorexia nervosa (Wilks λ, 0.843; P = .001) and in participants with eating disorders inversely correlated with body mass index (left nucleus accumbens: r = −0.291; 95% CI, −0.413 to −0.167; P < .001; right dorsal anterior insula: r = −0.228; 95% CI, −0.366 to −0.089; P = .001), eating disorder inventory–3 binge eating tendency (left nucleus accumbens: r = −0.207; 95% CI, −0.333 to −0.073; P = .004; right dorsal anterior insula: r = −0.220; 95% CI, −0.354 to −0.073; P = .002), and trait anxiety (left nucleus accumbens: r = −0.148; 95% CI, −0.288 to −0.003; P = .04; right dorsal anterior insula: r = −0.221; 95% CI, −0.357 to −0.076; P = .002). …”
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“…Our results indicate differences in plaque morphology, with ORF-deficient (ΔORF) viruses producing smaller plaques than those of the wild type (rSARS-CoV-2/WT). However, growth kinetics of ΔORF viruses were like those of rSARS-CoV-2/WT. …”
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“…ABSTRACT: The 2014 outbreak of clade 2.3.4.4A highly pathogenic avian influenza (HPAI) led to the culling of millions of commercial chickens and turkeys and death of various wild bird species. …”
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“…Group 20 was left non-vaccinated as a control. All vaccinated groups were divided and challenged with both viruses at 25 and 31 days of age. …”
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“…Despite the great strides, there are still many challenges in the decision-making regarding the upfront strategy in mCRC patients. …”
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“…Therefore, the number of CD3(+) T cells and the level of IL-6 on hospital admission may serve as predictive factors for identifying patients with wild-type virus infection who will have severe disease.…”
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“…With increased p16 protein levels, ANP‐, BNP‐ and GATA4‐positive cells or areas increased; however, LC3B‐positive cells or areas decreased in human myocardium. …”
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“…Mycolactone-dependent induction of SQSTM1 was reduced in eif2ak3(−/-)/perk(−/-) cells while the p-EIF2S1 antagonist ISRIB reversed the upregulation of SQSTM1 and reduced RB1CC1, WIPI2 and LC3B puncta formation. …”
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“…SIMPLE SUMMARY: It is estimated that a vast diversity of parasites populate our planet, many of them still to be discovered. Blood parasites (hemoparasites) of the phylum Apicomplexa may infect both vertebrates and invertebrates. …”
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“…The objectives of this study in Asian elephants were as follows: (1) To investigate the semen characteristics; (2) to compare the relative seminal vesicle size and semen characteristics; (3) to compare the semen characteristics between good-motile (>60% progressive motility) and poor-motile (<60% progressive motility) ejaculates; and (4) to investigate the pregnancy success rate after artificial insemination (AI) with combined chilled and frozen semen. MATERIALS AND METHODS: In total, 153 ejaculates were collected by manual rectal stimulation from 25 bulls. …”
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“…QYSLD has been used to treat non-small cell lung cancer (NSCLC) for over 20 years in clinical practice, and its curative effect is considered credible. …”
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“…BACKGROUND: Heterologous prime-boost SARS-CoV-2 vaccination is a widely accepted strategy during the COVID-19 pandemic, which generated a superior immune response than homologous vaccination strategy. …”
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“…Among 77 participants tested for T cell activity, mean (SD) T cell activity decreased from 98 (5.4) T cells/10(6) peripheral blood mononuclear cells to 59 (9.3) T cells/10(6) peripheral blood mononuclear cells. …”
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“…As part of our expertise, we perform antifungal susceptibility testing based on European Committee on Antimicrobial Susceptibility Testing (EUCAST) methodology on all isolates. The antifungal profiles help us monitor the emergence of resistant isolates, determine the susceptibility pattern of wild-type strains to new antifungals, and in specific cases, determine the relationship between clinical failure and selection/emergence of a less susceptible isolate. …”
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“…We also showed that NKB is a substrate of MKRN3 E3 ubiquitin ligase activity in vitro by demonstrating increased ubiquitination of NKB in cells co-transfected with expression vectors encoding MKRN3 and NKB and treated with proteasome inhibitor. …”
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