“…Caenorhabditis elegans is a powerful system for studying mechanosensation as this worm is well suited for in vivo functional imaging of neurons. …”
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“…Most inbred strains of mouse infected with the intestinal nematode Trichuris muris are resistant to infection expelling the parasite before adult worms establish. However, a few susceptible strains exist that are incapable of worm expulsion and harbor chronic infections of mature adult worms. …”
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“…Automated analysis of video can now generate extensive time series of pose and motion in freely-moving organisms. …”
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“…Therefore, we have screened a library of classical and non-sedating 1,4-benzodiazepines against Schistosoma mansoni and identified a series of imidazobenzodiazepines that immobilize worms in vitro. …”
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“…The drugs partially exerted their activity through inhibition of acetylcholinesterases, as worms treated in vitro and in vivo showed significant decreases in the activity of this class of enzymes. …”
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“…However, methods for quantifying complexity of worm movement using time series are still not well explored. …”
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“…Schistosomes are parasitic worms that can survive in the hostile environment of the human bloodstream where they appear refractory to both immune elimination and thrombus formation. …”
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“…First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. …”
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“…The present study examined the prevalence of parasitic infection among 300 fish samples collected from different markets in Assiut Governorate, Upper Egypt, using a series of detection techniques, including microscopic, parasitological, histopathological and morphometric methods. …”
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“…LEVEL OF EVIDENCE: IV, Case Series HOW TO CITE THIS ARTICLE: Haleem AM, Galal S, Nwawka OK, et al. …”
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“…Due to the lack of research on the infectious sources of Amphimerus sp. in the continent, we have developed a series of epidemiological studies with parasitological and molecular techniques to elucidate the endemicity of opisthorchiid fluke infections. …”
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“…Patterns observed were bag of worms, spaghetti like and vessels with terminal bulbs. …”
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“…Although nanoscopy is broadly applicable, classical model organisms, such as fruit flies, worms and mice, remained the leading subjects because combining the strength of sophisticated genetics, biochemistry and electrophysiology with the unparalleled resolution provided by super-resolution imaging appears as one of the most efficient approaches to understanding the basic cell biological questions and the molecular complexity of life. …”
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“…The lead identified in this series, 21 (AN15470), was found to have acceptable pharmacokinetic properties to enable an evaluation following oral dosing in an animal model of onchocerciasis. …”
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“…Results: We develop a worm straightening algorithm (WSA) that restacks cutting planes orthogonal to a ‘backbone’ that models the anterior–posterior axis of the worm. …”
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“…INTRODUCTION: Schistosomiasis, caused by trematode worms of the genus Schistosoma, has organ-specific morbidity due to host's inflammatory response to the oviposition of parasite eggs in vessels and organs. …”
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“…Supplementation of spermidine extends the lifespan of yeast, worms, flies, and mice, and dietary spermidine intake correlates with reduced human mortality. …”
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“…No preoperative diagnosis was made in this series. RESULTS: We found 11 patients with appendiceal ascariasis. …”
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“…Here, we have focused on the aging gonad in old animals, and show in detail that the aging gonad undergoes a massive uterine growth composed of endoreduplicating oocytes, yolk, and expanses of chromatin. We use a novel series of imaging techniques in combination with histological methodology for reconstructing aged worms in 3-dimensions, and show in old animals growing masses swelling inside the uterus to occupy most of the diameter of the worm. …”
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“…Preliminary investigations to understand adaptive features were also performed, showing a trend in carunculine abundance that fits into the evolutionary history of these worms. These findings shed light on the chemical ecology of amphinomids, giving reasons for the success of H. carunculata in benthic environments and providing promising novel metabolites for biotechnological implications.…”
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