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  1. 641
    “…The asymmetric unit of the title compound, 2C(10)H(18)N(+)·HPO(4) (2−)·1.5C(4)H(4)O(4), contains two adamantan-1-aminium cations, one hydrogen phosphate anion, and one and a half mol­ecules of fumaric acid, one of which exhibits crystallographic inversion symmetry. …”
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    Bis(adamantan-1-aminium) hydrogen phosphate fumaric acid sesquisolvate
  2. 642
    “…Fumaric acid (FA) is a promising biomass-derived building-block chemical. …”
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    Fumaric Acid Production in Saccharomyces cerevisiae by In Silico Aided Metabolic Engineering
  3. 643
    “…We report on an exceedingly rare case of cutaneous and uterine leiomyomatosis in a 58-year-old Caucasian woman associated with ovarian cystadenoma and complete deletion of the fumarate hydratase gene. All patients and their family members with verified mutation have to be regularly screened for associated neoplasms, in particular papillary renal cell carcinoma (HLRCC, hereditary leiomyomatosis and renal cell cancer).…”
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    Cutaneous and uterine leiomyomatosis and ovarian cystadenoma associated with deficiency of fumarate hydratase
  4. 644
    “…Current treatment options for most head and neck cancers continue to be surgical excision with or without radiation, radiation alone, or chemotherapy with radiation depending on location, stage of disease, and patient preference. Fusaric acid (FA) is a novel compound from a novel class of nicotinic acid derivatives that have activity against head and neck squamous cell carcinoma (HNSCC). …”
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    Determination of Oral Bioavailability of Fusaric Acid in Male Sprague-Dawley Rats
  5. 645
    “…The accumulation of fumarate in these cells has been linked to the tumorigenic process. …”
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    Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
  6. 646
    “…We measured changes in brain magnetization transfer ratio (MTR) as a potential indicator of myelin density in brain tissue of patients with relapsing-remitting multiple sclerosis (RRMS) treated with delayed-release dimethyl fumarate (DMF) in the Phase 3 DEFINE study. DEFINE was a randomized, double-blind, placebo-controlled study in which patients with RRMS were randomized 1:1:1 to 2 years of treatment with delayed-release DMF 240 mg twice daily (BID) or three times daily (TID) or placebo. …”
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    Magnetization transfer ratio in the delayed-release dimethyl fumarate DEFINE study
  7. 647
    “…OBJECTIVES: Our initiative aimed to produce recommendations on post-randomised controlled trial (RCT) trial extension studies (TES) reporting using European League Against Rheumatism (EULAR) standard operating procedures in order to achieve more meaningful output and standardisation of reports. …”
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    Development of EULAR recommendations for the reporting of clinical trial extension studies in rheumatology
  8. 648
    por Kalyankar, P., Panzade, P., Lahoti, S.
    Publicado 2015
    “…The objective of present study was to formulate directly compressible orodispersible tablets of quetiapine fumarate by sublimation method with a view to enhance patient compliance. …”
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    Formulation Design and Optimization of Orodispersible Tablets of Quetiapine Fumarate by Sublimation Method
  9. 649
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    Role of ultrasonography in the diagnosis of rheumatic diseases in light of ACR/EULAR guidelines
  10. 650
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    Nonfatal PML in a patient with multiple sclerosis treated with dimethyl fumarate
  11. 651
    “…OBJECTIVES: To compare patient-reported experiences of fingolimod and dimethyl fumarate. METHODS: Adult relapsing-remitting multiple sclerosis patients treated with fingolimod or dimethyl fumarate were recruited from an online patient community and completed an online survey about treatment side effects, discontinuation, and satisfaction. …”
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    The real-world patient experience of fingolimod and dimethyl fumarate for multiple sclerosis
  12. 652
    “…INTRODUCTION: The objective of this pilot study was to compare cerebral gray matter (GM) atrophy over 1 year in patients starting dimethyl fumarate (DMF) for multiple sclerosis (MS) to that of patients on no disease-modifying treatment (noDMT). …”
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    The Effect of Dimethyl Fumarate on Cerebral Gray Matter Atrophy in Multiple Sclerosis
  13. 653
    “…We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). …”
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    Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes
  14. 654
    “…Dimethyl fumarate (DMF) is an effective treatment option for relapsing–remitting multiple sclerosis (MS), but its therapeutic mechanism of action has not been fully elucidated. …”
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    Emerging Understanding of the Mechanism of Action for Dimethyl Fumarate in the Treatment of Multiple Sclerosis
  15. 655
    “…Here we designed and acquired proteomics, phosphoproteomics, and metabolomics experiments in fumarate hydratase (FH) deficient cells and developed a computational modelling approach to identify putative regulatory phosphorylation-sites of metabolic enzymes. …”
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    Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells
  16. 656
    “…The aluminum fumarate MOF A520 or MIL-53–FA is revealed to be a promising material for mechanical energy-related applications with performances in terms of work and heat energies which surpass those of any porous solids reported so far. …”
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    Mechanical energy storage performance of an aluminum fumarate metal–organic framework
  17. 657
    “…To find new strategies to restore demyelination-induced network alteration in addition to the ongoing remyelination, we tested the cytoprotective potential of dimethyl fumarate (DMF). Therapeutic treatment with DMF during remyelination significantly modified spatiotemporal stimulus propagation in the cortex, reduced the cognitive impairment, and prevented the demyelination-induced decrease in nuclear Nrf-2. …”
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    Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination
  18. 658
    “…OBJECTIVE: To infer molecular effectors of therapeutic effects and adverse events for dimethyl fumarate (DMF) in patients with relapsing-remitting MS (RRMS) using untargeted plasma metabolomics. …”
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    Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate
  19. 659
    “…The solid-state structures of the salts of two substituted tryptamines, namely N-isopropyl-N-methyl­tryptaminium (MiPT) fumarate {systematic name: [2-(1H-indol-3-yl)eth­yl](meth­yl)propan-2-yl­aza­nium 3-carb­oxy­prop-2-enoate}, C(14)H(21)N(2) (+)·C(4)H(3)O(4) (−), and 4-hy­droxy-N-isopropyl-N-methyl­tryptaminium (4-HO-MiPT) fumarate monohydrate {systematic name: [2-(4-hy­droxy-1H-indol-3-yl)eth­yl](meth­yl)propan-2-yl­aza­nium 3-carb­oxy­prop-2-enoate monohydrate}, C(14)H(21)N(2)O(+)·C(4)H(3)O(4) (−)·H(2)O, are reported. …”
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    The fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin
  20. 660
    “…Extensive investigations are being carried out to identify the molecular origin of resistance to chemo- and radio-therapy in GBM and find novel targets for therapy to improve overall survival rate. Dimethyl fumarate (DMF) has been shown to be a safe drug with limited short and long-term side effects, and fumaric acid esters (FAEs), including DMF, present both anti-oxidative and anti-inflammatory activity in different cell types and tissues. …”
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    Role of dimethyl fumarate in the treatment of glioblastoma multiforme: A review article
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