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  1. 781
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    Disseminated zoster with paresis in a multiple sclerosis patient treated with dimethyl fumarate
  2. 782
    “…Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome secondary to germline fumarate hydratase (FH) mutation presents with cutaneous and uterine leiomyomas, and a distinctive aggressive renal carcinoma. …”
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    Fumarate Hydratase–deficient Uterine Leiomyomas Occur in Both the Syndromic and Sporadic Settings
  3. 783
    por Liu, Shuang, Tao, Yong-Guang
    Publicado 2016
    “…We also found that LSH directly suppressed fumarate hydratase (FH), a key component of the tricarboxylic acid cycle, in combination with euchromatic histone-lysine N-methyltransferase 2 (EHMT2), also known as G9a. …”
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    Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver
  4. 784
    “…Interestingly, the cut-off value of the succinate:fumarate ratio was two-folds greater in RCCs than GISTs. …”
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    Utility of the succinate:fumarate ratio for assessing SDH dysfunction in different tumor types()
  5. 785
    “…METHODS: We examined longitudinal changes in biomarkers of monocyte activation (sCD14, sCD163), and systemic (IL-6, hsCRP, sTNFR-I and D-dimer) and vascular (Lp-PLA(2)) inflammation in a subgroup (N = 100 per arm) of participants enrolled in a randomized, placebo-controlled trial comparing elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF; TAF) to E/C/F/tenofovir disoproxil fumarate (E/C/F/TDF; TDF) in treatment-naïve adults. …”
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    Equivalent Decline in Inflammation Markers with Tenofovir Disoproxil Fumarate vs. Tenofovir Alafenamide
  6. 786
    “…Tenofovir disoproxil fumarate (TDF), the bisphosphonate ester prodrug of tenofovir (TFV), has poor bioavailability due to intestinal degradation and efflux transport. …”
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    Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate
  7. 787
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    Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death
  8. 788
    “…In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate metabolism, in normal and leukemic hematopoiesis. …”
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    Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions
  9. 789
    “…OBJECTIVE: To examine the mechanism underlying the preferential CD8(+) vs CD4(+) T-cell lymphopenia induced by dimethyl fumarate (DMF) treatment of MS. METHODS: Total lymphocyte counts and comprehensive T-cell subset analyses were performed in high-quality samples obtained from patients with MS prior to and serially following DMF treatment initiation. …”
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    Dimethyl fumarate–induced lymphopenia in MS due to differential T-cell subset apoptosis
  10. 790
    por Chaves, C, Ganguly, R, Ceresia, C, Camac, A
    Publicado 2017
    “…BACKGROUND: Recent data suggest that lymphopenia is more prevalent than reported in relapsing–remitting multiple sclerosis (RRMS) patients taking dimethyl fumarate (DMF). OBJECTIVE: The objective of this study was to investigate the effect of DMF on lymphocyte subtypes in RRMS patients with and without lymphopenia. …”
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    Lymphocyte subtypes in relapsing–remitting multiple sclerosis patients treated with dimethyl fumarate
  11. 791
    “…We evaluated the effect of dimethyl fumarate (DMF) treatment on B‐cell memory and cytokine production in 18 patients with relapsing remitting multiple sclerosis (RRMS) using peripheral blood mononuclear cells obtained prior to and at 6 months post‐DMF initiation. …”
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    Dimethyl fumarate alters B‐cell memory and cytokine production in MS patients
  12. 792
    “…The effects of dimethyl fumarate (DMF) on mycotoxins and animal growth performance are well documented. …”
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    Dimethyl fumarate reduces the risk of mycotoxins via improving intestinal barrier and microbiota
  13. 793
    “…BACKGROUND: Fingolimod (FTY) and dimethyl fumarate (DMF) are multiple sclerosis (MS) oral therapies that became available in 2010 and 2013, respectively. …”
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    Comparison of fingolimod and dimethyl fumarate in the treatment of multiple sclerosis: Two-year experience
  14. 794
    “…OBJECTIVE: To examine the temporal profile of absolute and lymphocyte subset data from dimethyl fumarate (DMF) start and relationships to disease behavior. …”
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    Patient outcomes influenced by reduced lymphocyte counts after dimethyl fumarate initiation
  15. 795
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    Liposome-Coated Iron Fumarate Metal-Organic Framework Nanoparticles for Combination Therapy
  16. 796
    “…OBJECTIVE: Immunological studies have demonstrated a plethora of beneficial effects of dimethyl fumarate (DMF) on various cell types. However, the cellular and molecular targets are incompletely understood and response markers are scarce. …”
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    The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis
  17. 797
    “…Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. …”
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    Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
  18. 798
    “…Osm1 and Frd1 are soluble fumarate reductases from yeast that are critical for allowing survival under anaerobic conditions. …”
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    Molecular basis of maintaining an oxidizing environment under anaerobiosis by soluble fumarate reductase
  19. 799
    “…BACKGROUND: Fumaric acid is widely used in food and pharmaceutical industries and is recognized as a versatile industrial chemical feedstock. …”
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    Metabolic engineering of the thermophilic filamentous fungus Myceliophthora thermophila to produce fumaric acid
  20. 800
    “…OBJECTIVE: Identify metabolic changes produced by dimethyl fumarate (DMF) treatment and link them to immunological effects. …”
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    Dimethyl fumarate treatment induces lipid metabolism alterations that are linked to immunological changes
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