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922por Phan, Isabelle, Subramanian, Sandhya, Olsen, Christian, Edwards, Thomas E., Guo, Wenjin, Zhang, Yang, Van Voorhis, Wesley C., Stewart, Lance J., Myler, Peter J.“…A structure alignment with human mitochondrial fumarate hydratase highlights the close similarity between R. prowazekii and mitochondrial enzymes.…”
Publicado 2011
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923por van de Sande, Marleen G. H., de Hair, Maria J. H., Schuller, Yvonne, van de Sande, Gijs P. M., Wijbrandts, Carla A., Dinant, Huib J., Gerlag, Danielle M., Tak, Paul P.“…OBJECTIVES: It has been shown in early arthritis cohorts that the 2010 ACR/EULAR criteria for rheumatoid arthritis (RA) enable an earlier diagnosis, perhaps at the cost of a somewhat more heterogeneous patient population. …”
Publicado 2012
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924por Tjandrawinata, Raymond R, Setiawati, Effi, Yunaidi, Danang Agung, Santoso, Iwan Dwi, Setiawati, Arini, Susanto, Liana W“…BACKGROUND: The present study was conducted to compare the bioavailability of two bisoprolol fumarate 5 mg film-coated tablet formulations (test and reference formulations). …”
Publicado 2012
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925por Li, Chunyu, Zuo, Cunwu, Deng, Guiming, Kuang, Ruibin, Yang, Qiaosong, Hu, Chunhua, Sheng, Ou, Zhang, Sheng, Ma, Lijun, Wei, Yuerong, Yang, Jing, Liu, Siwen, Biswas, Manosh Kumar, Viljoen, Altus, Yi, Ganjun“…Two toxins were consistently associated with Foc, fusaric acid (FA) and beauvericin (BEA). Cytotoxicity of the two toxins on banana protoplast was determined using the Alamar Blue assay. …”
Publicado 2013
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926por Kassem, Issmat I, Khatri, Mahesh, Sanad, Yasser M, Wolboldt, Melinda, Saif, Yehia M, Olson, Jonathan W, Rajashekara, Gireesh“…The methylmenaquinol:fumarate reductase (Mfr) of Campylobacter jejuni is a periplasmic respiratory (redox) protein that contributes to the metabolism of fumarate and displays homology to succinate dehydrogenase (Sdh). …”
Publicado 2014
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927por Nicholas, Jacqueline Ann, Boster, Aaron Lee, Imitola, Jaime, O’Connell, Colleen, Racke, Michael Karl“…Prior to approval for use in MS, DMF and its active metabolite, monomethyl fumarate, had been used for decades as two of the fumaric acid esters in Fumaderm(®), a medication used in Europe for the treatment of psoriasis. …”
Publicado 2014
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928por Arnold, Douglas L., Gold, Ralf, Kappos, Ludwig, Bar-Or, Amit, Giovannoni, Gavin, Selmaj, Krzysztof, Yang, Minhua, Zhang, Ray, Stephan, Monica, Sheikh, Sarah I., Dawson, Katherine T.“…In the Phase 3 DEFINE study, delayed-release dimethyl fumarate (DMF) 240 mg twice (BID) and three times daily (TID) significantly reduced the mean number of new or enlarging T2-hyperintense lesions and gadolinium-enhancing (Gd+) lesion activity at 2 years in patients (MRI cohort; n = 540) with relapsing–remitting MS. …”
Publicado 2014
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929por Miller, David H., Fox, Robert J., Phillips, J. Theodore, Hutchinson, Michael, Havrdova, Eva, Kita, Mariko, Wheeler-Kingshott, Claudia A.M., Tozer, Daniel J., MacManus, David G., Yousry, Tarek A., Goodsell, Mary, Yang, Minhua, Zhang, Ray, Viglietta, Vissia, Dawson, Katherine T.“…OBJECTIVE: To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, and magnetization transfer ratio (MTR) measures from the Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis (CONFIRM) study. …”
Publicado 2015
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930por Park, Jin-Su, Park, Min-Chan, Song, Jason Jungsik, Park, Yong-Beom, Lee, Soo-Kon, Lee, Sang-Won“…INTRODUCTION: We investigated how many patients, who presented with Raynaud’s phenomenon (RP) and who had not been classified as systemic sclerosis (SSc), would be reclassified as SSc, if the 2013 American College of Rheumatology (ACR)/the European League Against Rheumatism (EULAR) classification criteria were used. We also analyzed the predictive values of the reclassification as SSc in those patients. …”
Publicado 2015
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931por Dammeier, Nele, Schubert, Victoria, Hauser, Till-Karsten, Bornemann, Antje, Bischof, Felix“…A few cases of progressive multifocal leukoencephalopathy have been reported in patients treated with fumaric acid esters. CASE PRESENTATION: A 53-year-old Caucasian woman reported to our clinic with a first focal epileptic seizure and mild cognitive impairment. …”
Publicado 2015
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932por Inaoka, Daniel Ken, Shiba, Tomoo, Sato, Dan, Balogun, Emmanuel Oluwadare, Sasaki, Tsuyoshi, Nagahama, Madoka, Oda, Masatsugu, Matsuoka, Shigeru, Ohmori, Junko, Honma, Teruki, Inoue, Masayuki, Kita, Kiyoshi, Harada, Shigeharu“…Recent studies on the respiratory chain of Ascaris suum showed that the mitochondrial NADH-fumarate reductase system composed of complex I, rhodoquinone and complex II plays an important role in the anaerobic energy metabolism of adult A. suum. …”
Publicado 2015
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933“…AIM: The aim was to test whether the ethanolic extract of Fumaria indica (FI) possesses anti-inflammatory and analgesic activities, and fumaric acid (FA) could be one of its bioactive constituent involved in such activities of the extract. …”
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934“…Quetiapine fumarate is an antipsychotic drug with poor oral bioavailability (9%) due to first-pass metabolism. …”
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935por Iagnocco, A, Terslev, L, Backhaus, M, Balint, P, Bruyn, G A W, Damjanov, N, Filippucci, E, Hammer, H B, Jousse-Joulin, S, Kane, D, Koski, J M, Mandl, P, Möller, I, Peetrons, P, Schmidt, W, Szkudlarek, M, Vojinovic, J, Wakefield, R J, Hofer, M, D'Agostino, M A, Naredo, E“…OBJECTIVE: To produce educational guidelines for the conduct, content and format of theoretical and practical teaching at EULAR musculoskeletal ultrasound (MSUS) Teaching the Teachers (TTT) Courses. …”
Publicado 2015
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936por Pitarokoili, Kalliopi, Ambrosius, Björn, Meyer, Daniela, Schrewe, Lisa, Gold, Ralf“…BACKGROUND: Dimethyl fumarate is an immunomodulatory and neuroprotective drug, approved recently for the treatment of relapsing-remitting multiple sclerosis. …”
Publicado 2015
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937por Kappos, L, Giovannoni, G, Gold, R, Phillips, J T, Arnold, D L, Hotermans, C, Zhang, A, Viglietta, V, Fox, R J“…BACKGROUND AND PURPOSE: Delayed-release dimethyl fumarate (DMF, also known as gastro-resistant DMF), demonstrated efficacy and safety in relapsing−remitting multiple sclerosis in the 2-year, randomized, placebo-controlled, phase 3 DEFINE and CONFIRM trials. …”
Publicado 2015
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938IgA vasculitis in adults: the performance of the EULAR/PRINTO/PRES classification criteria in adultspor Hočevar, Alojzija, Rotar, Ziga, Jurčić, Vesna, Pižem, Jože, Čučnik, Saša, Vizjak, Alenka, van den Broeke, Rianne, Tomšič, Matija“…BACKGROUND: In 2010, EULAR/PRINTO/PRES proposed new classification criteria for paediatric IgA vasculitis (IgAV) that have a higher diagnostic sensitivity than the 1990 ACR criteria. …”
Publicado 2016
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939por Lundy, Steven K., Wu, Qi, Wang, Qin, Dowling, Catherine A., Taitano, Sophina H., Mao, Guangmei, Mao-Draayer, Yang“…OBJECTIVE: To test the hypothesis that dimethyl fumarate (Tecfidera, BG-12) affects B-cell subsets in patients with relapsing-remitting multiple sclerosis (RRMS). …”
Publicado 2016
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940“…Several drugs have been approved for treatment of multiple sclerosis (MS). Dimethyl fumarate (DMF) is utilized as an oral drug to treat this disease and is proven to be potent with less side effects than several other drugs. …”
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