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  1. 1481
    por Douglas, C. E.
    Publicado 1908
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    A Ten Years' Study of Cupar Water Supply (Clatto Waterworks), with Special Reference to the Germ-Content Thereof
  2. 1482
    “…The effect of delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on the Multiple Sclerosis Functional Composite (MSFC) was assessed using integrated Phase 3 DEFINE and CONFIRM data. …”
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    Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM
  3. 1483
    “…BACKGROUND: The objective of this study was to compare the efficacy, safety and tolerability of intravenous iron sucrose with that of oral ferrous fumarate in iron deficiency anemia during 14 to 34 weeks of pregnancy. …”
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    Intravenous iron sucrose v/s oral ferrous fumarate for treatment of anemia in pregnancy. A randomized controlled trial
  4. 1484
    “…This study was a meta-analysis of the literature on the efficacy and safety of tenofovir disoproxil fumarate (TDF) in preventing vertical transmission of hepatitis B in pregnancies with high viral load. …”
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    Efficacy and safety of tenofovir disoproxil fumarate in preventing vertical transmission of hepatitis B in pregnancies with high viral load
  5. 1485
    “…The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was used for preparation of TDF loaded liquid crystal precursors (LCP) consisting of GMO/Pluronic F127 and lactose monohydrate with an ability to in situ transform into stable cubic phases upon hydration. …”
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    QbD based approach for optimization of Tenofovir disoproxil fumarate loaded liquid crystal precursor with improved permeability
  6. 1486
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    Person-focused care for young people with rheumatic and musculoskeletal diseases: young rheumatologists' and EULAR Young PARE perspectives
  7. 1487
    “…A new triple fixed-dose combination of extrafine beclomethasone dipropionate (100 µg/puff)/formoterol fumarate (6 µg/puff)/glycopyrronium bromide (12.5 µg/puff) has been developed as a hydrofluoroalkane pressurized metered dose inhaler. …”
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    Triple therapy in COPD: new evidence with the extrafine fixed combination of beclomethasone dipropionate, formoterol fumarate, and glycopyrronium bromide
  8. 1488
    “…A calculator for electronic devices, such as computers and smartphones, facilitates the use of the European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria. CONCLUSIONS: The new EULAR/ACR classification criteria provide a patient’s probability of having IIM for use in clinical and research settings. …”
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    EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report
  9. 1489
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    Monolithic LC method applied to fesoterodine fumarate low dose extended-release tablets: Dissolution and release kinetics
  10. 1490
    “…The effects of dimethyl fumarate (DMF) on the immune system in multiple sclerosis (MS) are not completely elucidated. …”
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    Dimethyl fumarate induces a persistent change in the composition of the innate and adaptive immune system in multiple sclerosis patients
  11. 1491
    “…Two trials were conducted to investigate the effects of disodium fumarate (DSF; 0.00, 8.00, 10.00 and 12.00 mM) and thyme essential oil (TEO; 0.00, 100.00, 200.00, 300.00 and 400.00 µL L(-1)) solely and simultaneously (10.00 mM DSF along with 100.00, 200.00, 300.00 and 400 µL L(-1) TEO) on in vitro ruminal fermentation of a 50:50 alfalfa hay to concentrate diet. …”
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    Simultaneous use of thyme essential oil and disodium fumarate can improve in vitro ruminal microbial fermentation characteristics
  12. 1492
    “…The functional impairment in peak latency was significantly correlated with increased microglia/macrophages. Dimethyl fumarate (DMF; 100 mg/kg), a drug with anti-inflammatory properties, was found to reduce peak latency but not axonal refractoriness. …”
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    Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators
  13. 1493
    “…The survey was mailed to members of the European League Against Rheumatism (EULAR) School of Rheumatology (Undergraduate Classroom) and to EULAR Standing Committee on Education and Training members in January 2017, with a reminder in February 2017. …”
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    Cross-sectional survey of the undergraduate rheumatology curriculum in European medical schools: a EULAR School of Rheumatology initiative
  14. 1494
    “…METHODS: Isolated perfused hearts were given hyperpolarized [1,4–(13)C(2)]fumarate at baseline, immediately after 20 min of ischemia, and after 45 min of reperfusion. …”
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    Hyperpolarized [1,4-(13)C(2)]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis
  15. 1495
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    2258. Clinical Predictors of Acute Kidney Injury in HIV Infected Patients Treated With Tenofovir Disoproxil Fumarate (TDF)
  16. 1496
    “…BACKGROUND: Our recent study showed significantly lower bone mineral content (BMC) in HIV-exposed uninfected (HEU) neonates born to HIV-infected (HIV+) mothers who took tenofovir disoproxil fumarate (TDF) in late pregnancy compared with no TDF use. …”
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    2261. Phosphaturia in HIV-Exposed Uninfected Neonates Associated With Maternal Use of Tenofovir Disoproxil Fumarate in Late Pregnancy
  17. 1497
    “…We prospectively assessed the long‐term safety and efficacy of switching to tenofovir disoproxil fumarate (TDF) from HBIg. METHODS: An open‐label, multicenter switch study was conducted to evaluate the substitution of TDF for HBIg whilst continuing lamivudine (LAM) therapy in preventing the recurrence of HBV in patients who had been maintained as hepatitis B surface antigen (HBsAg)‐negative posttransplantation for at least 12 months. …”
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    Long‐term safety and efficacy of tenofovir disoproxil fumarate substitution for hepatitis B immunoglobulin following liver transplantation
  18. 1498
    “…PURPOSE: Metabolic aberrations have been described in neoplasms with mutations in the Krebs cycle genes encoding succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH). …”
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    Metabolome-guided genomics to identify mutations in isocitrate dehydrogenase, fumarate hydratase and succinate dehydrogenase genes in pheochromocytoma and paraganglioma
  19. 1499
    por Drusian, Luca, Boletta, Alessandra
    Publicado 2018
    “…We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase, to accumulation of the oncometabolite fumarate, and gradual transformation from benign cysts into cystadenomas and papillary carcinomas.…”
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    mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
  20. 1500
    “…BACKGROUND: Dimethyl fumarate (DMF) is licensed for treatment of relapsing–remitting multiple sclerosis (RRMS). …”
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    Time course of lymphocyte repopulation after dimethyl fumarate-induced grade 3 lymphopenia: contribution of patient age
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