“…Hematology, with its strong connection to the diagnostic laboratory, is ideally situated to provide clinical exposure that allows clear correlation between patient presentation and natural history, foundational basic science, the diagnostic laboratory, and clinical management. [Figure: see text] DISCLOSURES: Means:WoltersKluwer: Patents & Royalties: Wintrobe Clinical Hematology editor; UpToDate author, editor; Cambridge University Press: Patents & Royalties: textbook editor; SpringerNature: Patents & Royalties: Textbook editor.…”
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“…Moreover, to the best of our knowledge, for the first time this study disaggregates figures and stratifies analyses by HIV infection. …”
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“…The trend towards improvement of professional fulfillment levels and stability in burnout levels between W1 and W2 may also provide important insight on SGO member wellness and its temporal associations in response to external stressors, while also highlighting the associations of burnout with pan positive screening for anxiety, depression, and PTSD, further adding to the ongoing need to address these mental health issues for our healthcare providers. [Figure: see text]…”
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“…CFDC and comparator activities were analyzed against resistant and molecularly characterized P. aeruginosa (PSA) and A. baumannii-calcoaceticus complex (ACB) as part of the SENTRY Antimicrobial Surveillance Program. [Figure: see text] METHODS: 2,241 PSA and 682 ACB were consecutively collected from 63 US sites in 2020-2021. …”
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“…We evaluated the activity of ATM-AVI against S. maltophilia and B. cepacia from US hospitals. [Figure: see text] METHODS: 1,565 S. maltophilia and 219 B. cepacia were consecutively collected (1/patient) in 77 US medical centers in 2016-2021 and susceptibility tested by CLSI broth microdilution method. …”
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“….% to all 4 resistance phenotypes. [Figure: see text] CONCLUSION: The high prevalence of co-resistance in 30-day non-duplicate outpatient K. pneumoniae urinary isolates, particularly towards NFT (70–80% of isolates), limits the effective oral treatment options for uUTI. …”
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“…We evaluated the in vitro activity of RZF, caspofungin (CSF), micafungin (MCF), and anidulafungin (ANF) against a worldwide collection of fungal isolates causing invasive infection. [Figure: see text] METHODS: 830 isolates were collected from Europe (EU; 40.2%), North America (NA; 31.6%), Asia-Pacific (APAC; 15.3%), and Latin America (LA; 12.9%), identified by MALDI-TOF and/or sequencing, and tested by CLSI broth microdilution. …”
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“…We evaluated the in vitro activity of CTB-AVI against ENT causing cUTI. [Figure: see text] METHODS: 3,216 isolates (1/patient) were consecutively collected from patients with cUTI in 72 hospitals from 25 countries in 2021 then susceptibility (S) tested by CLSI broth microdilution. …”
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“…Seroconversion rates 1–8 weeks after 3(rd) and 4(th) dose were both 99.9%. Figure 1 compares GMTs with 95% CI by weeks after each vaccine dose. …”
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“…Using the same PK-PD target endpoints for each indication, overall percent probabilities of PK-PD target attainment (i.e., averaged over each MIC distribution) were > 99.9% for SA and Streptococcus species or S. pneumoniae and ≥ 98.7% for non-ESBL-producing ENT subsets. [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: These data provided support for a dosing regimen of ceftobiprole 500 mg IV every 8 hours for patients with ABSSSI or CABP. …”
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“…Summary statistics for PK/PD analyses are shown in Figure. [Figure: see text] CONCLUSION: Oral 1(st)-3(rd) generation cephalosporins exhibited efficacy against SA and EC in the mouse thigh infection model. …”
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“…Descriptive statistics such as frequency and other summary statistics were used for describing sociodemographic variables and determining the prevalence of diarrhea and intestinal parasites. Tables, figures, and texts were used to present the findings. …”
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“…Preoperative, anteroposterior pelvic radiographs were obtained for each patient and semi-automated, quantitative JSW measurements were performed at 3 predefined fixed locations per hip (10, 30, and 50 degrees with respect to a polar coordinate system; Figure 1). All measurements were obtained by an independent assessor blinded to other radiographic or clinical information, with high reliability (intra- class correlations > 0.8), as previously described in literature. …”
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“…A thirty percent defect was then created in all glenoid specimens and both distal tibia and distal radius grafts were harvested to assess graft fit post-fixation [Figure 1]. CTs were also analyzed to assess bony ROC and BMD for each specimen. …”
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“…Cartilage status in the PFJ between ACLR alone group and ACLR+LET group were compared by quantitative MRI (qMRI) analysis of T2 and T1 rho sequences (figure 1), and qualitative assessment by ACL osteoarthritis score (ACLOAS) on post-operative two year MRI for surgical and contralateral non-surgical knees. …”
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“…RESULTS: Fourteen studies including 611 patients (224 male, 387 female) were analyzed (Figure 1). Four surgical cohorts were identified: Anterior cruciate ligament reconstruction (ACLR), total hip arthroplasty (THA), hip fractures (THA, revision THA, hip resurfacing), and total knee arthroplasty (TKA). …”
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“…Based on clinical priority ranking, the strongest signals were found for paroxetine, duloxetine, venlafaxine and desvenlafaxine (figure 1), being comparable to buprenorphine. Severe reactions were more frequently reported in males, adolescents, persons with multiple medications, and with longer treatment duration. …”
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“…We evaluated a large collection of CRE isolates nonsusceptible (NS) to these BLIs. [Figure: see text] METHODS: 24,580 Enterobacterales isolates were consecutively collected (1/patient) in 2020–2022 from 64 medical centers located in Western Europe (W-EU; 27 centers in 10 countries), Eastern Europe (E-EU; 13 centers in 9 countries), Latin America (LATMA; 8 centers in 6 countries), and the Asia-Pacific region (APAC; 16 centers in 8 countries). …”
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“…Antimicrobial Activity of Cefiderocol and Comparator Agents Against Isolates of Pseudomonas aeruginosa, Acinetobacter baumannii-calcoaceticus species complex, and Stenotrophomonas maltophilia by Infection Type from United States Hospitals [Figure: see text] METHODS: 3,383 PSA, 910 ABC and 657 S. maltophilia isolates from US hospitals were tested for susceptibility (%S) using broth microdilution with cation-adjusted Mueller-Hinton broth (CAMHB) or iron-depleted CAMHB for CFDC. …”
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“…Additionally, we found that a negative clinical test was associated with lower odds of antiviral receipt, and receipt varied significantly by study site. Table [Figure: see text] Logistic regression model of influenza-specific antiviral receipt among hospitalized children testing positive for influenza by research testing, December 1, 2016, and March 31, 2020 (N=1,120). …”
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