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34581por Abdelaal, Mahmoud A.Z., Abdelrahman, Dyala, Cengiz, Mahir, Yavuzer, Hakan, Yavuzer, Serap, Bien, Ivy, Bhuva, Preeti, Pham, Jessica V, Siu, Royal, Tang, Mengdi, Ward, Ashley, Goodrow, Jason, Ludlum, Peter, Stark, Charles W., Perrine, Susan P.“…The data as a whole provides a strong rationale for a controlled clinical trial of PGLG toreducesevere COVID-19 in high-risk SCD patients and improve outcomes if infection occurs. [Figure: see text] DISCLOSURES: Cengiz:Biruni University Medical Faculty:Current Employment;Istanbul University-Cerrahpasa Medical Faculty:Ended employment in the past 24 months.Yavuzer:Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of Internal Medicine, Division of Geriatrics:Current Employment.Yavuzer:Biruni University Medical Faculty:Current Employment;Istanbul University-Cerrahpasa Mediacl Faculty:Ended employment in the past 24 months.Tang:Kaiser Permanente:Current Employment.Ward:Emmaus Medical, Inc.…”
Publicado 2020
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34582por Cattaneo, Chiara, Cancelli, Valeria, Pagani, Chiara, Tucci, Alessandra, Rossi, Giuseppe, Imberti, Luisa, Sottini, Alessandra, Dobbs, Kerry, Shaw, Elana, Notarangelo, Luigi D., Cohen, Jeffrey, Burbelo, Peter“…Ab response persists at 3 months; the study is ongoing and further data will be available at time of meeting. [Figure: see text] DISCLOSURES: Tucci:Amgen: Consultancy. …”
Publicado 2020
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34583por Ollila, Thomas A., Masel, Rebecca, Reagan, John L, Paiva, Kimberly, Lu, Shaolei, Rogers, Ralph, Zayac, Adam, Taher, Rashida, Yakirevich, Inna, Niroula, Rabin, Barth, Peter, Olszewski, Adam J.“…Pts with active HMs or those within 2 years of last therapy should be particularly aware of the risk of infection despite vaccines and should be considered for strategies to enhance anti-COVID-19 immunity regardless of age. [Figure: see text] DISCLOSURES: Olszewski: TG Therapeutics: Research Funding; PrecisionBio: Research Funding; Celldex Therapeutics: Research Funding; Acrotech Pharma: Research Funding; Genentech, Inc.: Research Funding; Genmab: Research Funding.…”
Publicado 2021
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34584por Loke, (Justin) Ching Ting, Gaskell, Charlotte, Fox, Sonia, Fletcher, Rachel, Thomas, Catherine, Hopkins, Louise, Kumari, Anita, Boucher, Rebecca H., Nunnick, Jane, Knapper, Steve, Toth, Arpad, Byrne, Jennifer, O'Nions, Jenny, Khan, Anjum, Zhao, Rui, Pillai, Arvind, Tholouli, Eleni, Dungarwalla, Moez, Randall, Katie, Dillon, Richard, Murray, Duncan, Culligan, Dominic, McMullin, Mary Frances, Chan, Yuen Ling Tracey, Drew, Victoria, Murthy, Vidhya, Krishnamurthy, Pramila, Neelakantan, Pratap, Rider, Tom, Wandroo, Farooq A, Rafferty, Mark, Huang, Ya-Wen, Moore, Sally, Mehta, Priyanka, Partridge, David G, Craddock, Charles, Lowe, David, Stanworth, Simon J.“…Acknowledgments: This study was funded by Cure Leukaemia under the Trials Acceleration Program (TAP), and grants from BMS and Blood Cancer UK. [Figure: see text] DISCLOSURES: Loke: Novartis: Other: Travel; Janssen: Honoraria; Amgen: Honoraria; Pfizer: Honoraria; Daichi Sankyo: Other: Travel. …”
Publicado 2021
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34585por Cicin-Sain, Caroline, Huang, Alice, Pasin, Chloe, Epp, Selina, Mueller, Nicolas J, Nilsson, Jakob, Vilinovszki, Oliver, Nair, Gayathri, Wolfensberger, Nathan, Hockl, Philipp, Schanz, Urs, Trkola, Alexandra, Kouyos, Roger, Hasse, Barbara, Zinkernagel, Annelies, Manz, Markus G, Abela, Irene A, Mueller, Antonia MS“…Monitoring AB development in all allo-HCT recipients and vulnerable patients with other immunocompromising conditions may be crucial to determine those at increased risk for infection and for the timing of booster vaccines. [Figure: see text] DISCLOSURES: Manz: CDR-Life Inc: Consultancy, Current holder of stock options in a privately-held company; University of Zurich: Patents & Royalties: CD117xCD3 TEA.…”
Publicado 2021
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34586por Le Bourgeois, Amandine, Coste-Burel, Marianne, Guillaume, Thierry, Peterlin, Pierre, Garnier, Alice, Imbert, Berthe-Marie, Drumel, Thomas, Mahé, Béatrice, Dubruille, Viviane, Blin, Nicolas, Lok, Anne, Touzeau, Cyrille, Gastinne, Thomas, Tessoulin, Benoit, Jullien, Maxime, Vantyghem, Sophie, Bene, Marie C, Moreau, Philippe, Le Gouill, Steven, Chevallier, Patrice“…Conclusion This study shows the interest of a third dose of BNT162b2 anti-SARS-CoV-2 messenger RNA vaccine after allograft as more patients are documented with less decrease of IgG titers and the highest IgG values after V3. [Figure: see text] DISCLOSURES: Moreau: Abbvie: Honoraria; Amgen: Honoraria; Janssen: Honoraria; Sanofi: Honoraria; Celgene BMS: Honoraria; Oncopeptides: Honoraria.…”
Publicado 2021
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34587por Amanam, Idoroenyi, Yao, Janny M., Puing, Alfredo, Tsai, Ni-Chun, Samuels, Diana, Ngo, Dat, Ho, Stephanie, Ali, Haris, Aribi, Ahmed, Arslan, Shukaib, Artz, Andrew S., Htut, Myo, Koller, Paul, Salhotra, Amandeep, Sandhu, Karamjeet S., Nikolaenko, Liana, Pawlowska, Anna B, Shouse, Geoffrey, Stein, Anthony S., Marcucci, Guido, Forman, Stephen J, Nakamura, Ryotaro, Dadwal, Sanjeet S, Al Malki, Monzr M.“…Thus, the access to SARS-COV2 mAb in this population who is at increased risk for complications from SARS-COV2 infection is critical in reducing progression to severe COVID-19 disease and hospitalization. [Figure: see text] DISCLOSURES: Ali: Incyte: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; CTI BioPharma: Membership on an entity's Board of Directors or advisory committees; BMS: Speakers Bureau. …”
Publicado 2021
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34588por Abdallah, Al-Ola, Mahmoudjafari, Zahra, Mohan, Meera, McGuirk, Joseph P., Remker, Cassie, Foss, Margaret, Karloff, Ellie, Fitch, Heather, Mohyuddin, Ghulam Rehman, Atrash, Shebli“…Further prospective studies should ascertain the value of a 3 (rd) vaccine dose in this population. [Figure: see text] DISCLOSURES: Mahmoudjafari: Omeros: Membership on an entity's Board of Directors or advisory committees; GSK: Membership on an entity's Board of Directors or advisory committees; Incyte: Membership on an entity's Board of Directors or advisory committees. …”
Publicado 2021
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34589por Chu, Yaya, Milner, Jordan, Lamb, Margaret, Maryamchik, Elena, Rigot, Olivia, Ayello, Janet, Harrison, Lauren, Shaw, Rosemarie, Behbehani, Greg K., Mardis, Elaine R., Miller, Katherine E, Venkata, Lakshmi Prakruthi Rao, Chang, Hsiaochi, Lee, Dean Anthony, Rosenthal, Elana Y., Kadauke, Stephan, Bunin, Nancy, Talano, Julie-An, Johnson, Bryon, Wang, Yongping, Cairo, Mitchell S.“…These data serve as pre-clinical validation for an ongoing clinical trial utilizing related HLA-matched and haplo-identical SARS CoV-2 vCTLs for the treatment of patients with mild and moderate SARS-CoV-2 disease (IND #27260, NCT# 04896606). [Figure: see text] DISCLOSURES: Lee: Kiadis Pharma: Divested equity in a private or publicly-traded company in the past 24 months, Honoraria, Membership on an entity's Board of Directors or advisory committees, Patents & Royalties, Research Funding; Courier Therapeutics: Current holder of individual stocks in a privately-held company. …”
Publicado 2021
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34590por Malhotra, Suchi Kapoor, White, Howard, Dela Cruz, Nina Ashley O., Saran, Ashrita, Eyers, John, John, Denny, Beveridge, Ella, Blöndal, Nina“…By contrast, Kenya and Indonesia have <30, Laos and Morocco <20, Tanzania and Bolivia <10, and Mauritania only 1 km per 100 km(2). As these figures show, there is a significant backlog of transport infrastructure investment in both rural and urban areas, especially in sub‐Saharan Africa. …”
Publicado 2021
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34591“…Findings were then grouped into generic categories such as infectious, cardiac, etc. (see Figure 7). ECG: All patient notes were examined in the ‘Investigations’ section to determine if an ECG was included. …”
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34592“…. — Further neuropsychological testing identified a global reduction in general intellectual function, with severe executive function deficits as well as poor verbal working — Neurology opinion obtained as a case of young onset FTD — MRI scan of the brain showed substantial bilateral, symmetrical frontal atrophy, with no evidence of white matter changes that would be typical of a vascular, vasculitic or inflammatory cause (figure 1). In addition, autoimmune encephalitis was negative; and HIV and syphilis serology were all normal or negative. …”
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34593por Kan, Daxue, Lyu, Lianju, Yao, Wenqing, Ye, Xinya, Zan, Bing, Li, Danyang, Yan, Xiaoya, Huang, Weichiao“…There was no difference between sadness group and neutral emotion group (P = 0.504) (see Figure 2b). The main effect of emotion on MCT injury was significant, f (2, 99) = 4.01, P = 0.021, η 2p=0.08. …”
Publicado 2022
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34594por Jenkins, Kimberly C, Zabor, Emily C, Mooney, Lindsey A.R., Gerds, Aaron T., O'Hop, Kerry, Guy, Makenzie, Kilbane, Megan, Pennell, Nathan A, Sekeres, Mikkael A.“…Preliminary employee satisfaction surveys also reveal a high degree of satisfaction when working from home. [Figure: see text] DISCLOSURES: Gerds:Apexx Oncology: Consultancy; Imago Biosciences: Research Funding; AstraZeneca/MedImmune: Consultancy; Roche/Genentech: Research Funding; Gilead Sciences: Research Funding; Incyte Corporation: Consultancy, Research Funding; Sierra Oncology: Research Funding; Celgene: Consultancy, Research Funding; Pfizer: Research Funding; CTI Biopharma: Consultancy, Research Funding. …”
Publicado 2020
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34595por Kamenaga, Tomoyuki, Haneda, Masahiko, Brophy, Robert, Nahal, Chadi, O’Keefe, Regis, Clohisy, John, Garrido, Cecilia Pascual“…The entire list of differentially expressed genes was found to be significantly associated with 42 canonical pathways, including 25 up-regulated and 17 down-regulated pathways in early FAI group (Figure-2). Several pathways: Peroxisome proliferator-activated receptor (PPAR) signaling pathway, Phosphatidylinositol-3-kinase/activate protein kinase (PI3K/Akt) signaling pathway, and Hypoxia-inducible factor 1 (HIF1) have been previously reported as associated with OA. …”
Publicado 2022
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34596por Hamilton, P G, Buhler, K, Kaplan, G, Lu, C, Seow, C, Novak, K, Panaccione, R, Ma, C“…The pooled placebo clinical response rate was 24.4% [95% CI 12.4%, 38.4%] (Figure 1), with substantial heterogeneity (I2=60.8%, p<0.01). …”
Publicado 2023
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34597por VanScoy, Brian D, Conde, Haley, Vincent, Catherine E, Bhavnani, Sujata M, Aronin, Steven I, Puttagunta, Sailaja, Ambrose, Paul G“…[Figure: see text] CONCLUSION: These data support the selection of sulopenem etzadroxil/probenecid 500 mg/500 mg PO q12h, which minimized the potential for on-therapy drug-resistance amplification. …”
Publicado 2023
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34598por Garcia-Manero, Guillermo, McCloskey, James K, Griffiths, Elizabeth A., Yee, Karen, Zeidan, Amer M., Al-Kali, Aref, Deeg, H. Joachim, Patel, Prapti, Sabloff, Mitchell, Keating, Mary-Margaret, Dao, Kim-Hien, Zhu, Nancy, Gabrail, Nashat Y., Fazal, Salman, Maly, Joseph, Odenike, Olatoyosi, Kantarjian, Hagop, DeZern, Amy E., O'Connell, Casey L., Roboz, Gail J., Busque, Lambert, Wells, Richard A., Amin, Harshad, Randhawa, Jasleen K., Leber, Brian, Hao, Yong, Keer, Harold N., Azab, Mohammad, Savona, Michael R.“…With approximately 32 months of median follow up, neither median leukemia-free survival (mLFS) nor mOS had been reached (Figure 1). Twelve pts (17%) went on to allogeneic stem cell transplant. …”
Publicado 2021
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34599por Liisborg, Charlotte“…Vi foreslår derfor en AMD‐model (Figur 18) hvor inflammation kan initiere og accelerere den normale aldersafhængige akkumulation af affaldsstoffer i nethinden, som senere udvikler sig til druser, medførende øget lokal inflammation og med tiden tidlig og intermediær AMD. …”
Publicado 2022
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34600“…As at 6 hours L(+) was only 72 and at 28 hours only 91, we doubt whether L(+) ever reaches above 150, and therefore hardly expect Ehrlich's figures of 200 to be realized. When we seek to analyze the above-described process, we find certain facts which seem partly to explain it. …”
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