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  1. 51381
    “…CONCLUSIONS: hTf localization in MG cells from Tg mice was reminiscent of that reported for aged human retina and age-related macular degeneration, both conditions associated with iron deposition. …”
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    The protective role of transferrin in Müller glial cells after iron-induced toxicity
  2. 51382
    “…The purpose of this study was to determine whether mice exposed to chronic cigarette smoke develop features of early age-related macular degeneration (AMD). Two month old C57Bl6 mice were exposed to either filtered air or cigarette smoke in a smoking chamber for 5 h/day, 5 days/week for 6 months. …”
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    Chronic Cigarette Smoke Causes Oxidative Damage and Apoptosis to Retinal Pigmented Epithelial Cells in Mice
  3. 51383
    por Wei, Yan, Wang, Xu, Wang, Ling
    Publicado 2009
    “…However, their presence and role in human retinal pigment epithelial (RPE) cells, which play a key role in initiating and developing age related macular degeneration (ARMD), have never been investigated. …”
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    Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells
  4. 51384
    “…Many virulence factors are involved in the pathogenesis, namely capsular polysaccharides, RTX toxins, LPS and many iron acquisition systems. …”
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    Transcriptional profiling of Actinobacillus pleuropneumoniae during the acute phase of a natural infection in pigs
  5. 51385
    “…Using best-corrected visual acuity for classification, the single most important cause for visual impairment was cystoid macular edema in the aphakic group and posterior capsule opacification in the pseudophakic group. …”
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    Outcomes of cataract surgery in a rural and urban south Indian population
  6. 51386
    “…LCA1 patients present in infancy with severely impaired vision and extinguished electroretinogram (ERG) but retain some photoreceptors in both their macular and peripheral retina for years. Like LCA1 patients, loss of cone function in the GC1 knockout (GC1KO) mouse precedes cone degeneration. …”
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    Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse
  7. 51387
    “…RESULTS: Colonyzer is a collection of image analysis algorithms for automatic quantification of the size, granularity, colour and location of micro-organism cultures grown on solid agar. …”
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    Colonyzer: automated quantification of micro-organism growth characteristics on solid agar
  8. 51388
    “…METHODOLOGY/PRINCIPAL FINDINGS: Human retinal pigment epithelial (RPE) and rat RGC5 cells transfected to overexpress wild type optineurin were incubated with Texas Red-Tf to evaluate Tf uptake. Granular structures or dots referred to as foci formed in perinuclear regions after transfection. …”
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    Impairment of Protein Trafficking upon Overexpression and Mutation of Optineurin
  9. 51389
    “…However, PADI4 showed granular cellular distribution in the tumor tissues that were isolated from grade I cystadenocarcinoma. …”
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    Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors
  10. 51390
    “…BACKGROUND: In industrialised nations age-related macular degeneration (AMD) is the most common cause of blindness and severe visual impairment. …”
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    Evaluation of optical coherence tomography in the diagnosis of age related macula degeneration compared with fluorescence angiography
  11. 51391
    “…BACKGROUND: Hedgehog (HH) signaling is critical for the expansion of granule neuron precursors (GNPs) within the external granular layer (EGL) during cerebellar development. …”
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    Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures
  12. 51392
    “…CONCLUSIONS: VEGF-B overexpression promoted pathological retinal and choroidal NV and BRB breakdown without causing inflammation, which is associated with the progression of diabetic retinopathy and age-related macular degeneration, showing that these complications are not dependent on inflammation. …”
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    Vascular endothelial growth factor-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation
  13. 51393
    “…AP200 contains the pilus islet 2 and, although its phenotype corresponds to serotype 11A, it contains an 11D capsular locus. Chromosomal rearrangements resulting from a large inversion across the replication axis, and horizontal gene transfer events were observed. …”
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    Complete genome sequence of a serotype 11A, ST62 Streptococcus pneumoniae invasive isolate
  14. 51394
    “…Here, we investigate the consequences of aHUS-linked mutations (R53H and R78G) within the FH N-terminal complement control protein module that also carries the I62V variation linked to dense-deposit disease and age-related macular degeneration. This module contributes to a four-module C3b-binding site (FH1–4) needed for complement regulation and sufficient for fluid-phase regulatory activity. …”
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    Disease-associated N-terminal Complement Factor H Mutations Perturb Cofactor and Decay-accelerating Activities
  15. 51395
    “…RESULTS: We found that Zac1 has a complex expression profile in the developing cerebellum, including in two proliferating progenitor populations; the cerebellar ventricular zone and the external granular layer overlying posterior cerebellar lobules IX and X. …”
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    Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum
  16. 51396
    “…OBJECTIVE: VEGFR1 and 2 signaling have both been increasingly shown to mediate complications of ischemic retinopathies, including retinopathy of prematurity (ROP), age-related macular degeneration (AMD), and diabetic retinopathy (DR). …”
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    Blockade of VEGFR1 and 2 Suppresses Pathological Angiogenesis and Vascular Leakage in the Eye
  17. 51397
    “…BACKGROUND: Drusen are common features in the ageing macula associated with exudative Age-Related Macular Degeneration (ARMD). They are visible in retinal images and their quantitative analysis is important in the follow up of the ARMD. …”
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    Automated drusen detection in retinal images using analytical modelling algorithms
  18. 51398
    “…PURPOSE: Oxidative stress damage to retinal pigment epithelial (RPE) cells is thought to play a critical role in the pathogenesis of age-related macular degeneration (AMD). This study was conducted to investigate the protective effect of canolol against oxidative stress-induced cell death in ARPE-19 cells and its underlying mechanism. …”
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    Protective effect of canolol from oxidative stress-induced cell damage in ARPE-19 cells via an ERK mediated antioxidative pathway
  19. 51399
    por Worrall, Eve, Fillinger, Ulrike
    Publicado 2011
    “…RESULTS: The results show that for programmes using the same granular formulation larviciding costs the least pppy in Dar es Salaam (US$0.94), approximately 60% more in Vihiga District (US$1.50) and the most in Mbita Division (US$2.50). …”
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    Large-scale use of mosquito larval source management for malaria control in Africa: a cost analysis
  20. 51400
    “…RESULTS: Conversion of arabinose and glucose to hydrogen, by extreme thermophilic, anaerobic, mixed cultures was studied in continuous (70°C, pH 5.5) and batch (70°C, pH 5.5 and pH 7) assays. Two expanded granular sludge bed (EGSB) reactors, R(arab )and R(gluc), were continuously fed with arabinose and glucose, respectively. …”
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    Biohydrogen production from arabinose and glucose using extreme thermophilic anaerobic mixed cultures
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