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  1. 51861
    “…We hypothesize that morpholino-induced upregulation of sFlt-1 will suppress angiogenesis in clinically relevant models of macular degeneration and breast cancer. METHODS AND FINDINGS: In vivo morpholino constructs were designed to target murine exon/intron 13 junction of the Flt-1 transcript denoted VEGFR1_MOe13; standard nonspecific morpholino was used as control. …”
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    Morpholino-Mediated Increase in Soluble Flt-1 Expression Results in Decreased Ocular and Tumor Neovascularization
  2. 51862
    “…RESULTS: Choroidal involvement resolved in 10/15 patients, five had partial improvement; vasculitis resolved in 1/1 patient; papillitis resolved in 7/8 patients, one had partial response; macular edema resolved in 5/8 patients, three had partial response; vitreous cleared completely in 5/5 patients. …”
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    Adalimumab successful in sarcoidosis patients with refractory chronic non-infectious uveitis
  3. 51863
    “…Defining the role of Ccl2-Ccr2 and Cx3cl1-Cx3cr1 signalling for retinal pathology is of particular interest because of its potential role in age-related macular degeneration (AMD). Ccl2, Ccr2, and Cx3cr1 signalling defects impair macrophage trafficking, but have, in several conflicting studies, been reported to show different degrees of age-related retinal degeneration. …”
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    Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling
  4. 51864
    “…PURPOSE: Biologically uncommon D-β-aspartyl (D-β-Asp) residues have been detected in proteins from various human tissues from elderly donors and are connected with cataract, age-related macular degeneration, Alzheimer disease and UV-irradiated skin. …”
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    Characterization of an antibody that recognizes peptides containing D-β-aspartyl residues
  5. 51865
    “…PVA and BCVA worse than 6/60 was seen in 74 (4.8%; 95% CI, 3.8–6%) and 49 subjects (3.2%; 95% CI, 2.4–4.2%), respectively. Posterior capsular opacification was seen in 51 of 1316 pseudophakic eyes (3.9%; 95% CI, 2.9–5.1%). …”
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    Population Based Outcomes of Cataract Surgery in Three Tribal Areas of Andhra Pradesh, India: Risk Factors for Poor Outcomes
  6. 51866
    “…Combined with AR treating sections with proteinase K solution (enzymatic-AR), the nsCSA system visualized granular immunostaining of the complex present form of Tax in a small number of ATLL cells in most cases, presenting the possibility of etiological pathological diagnosis of ATLL and suggesting that the complex present form of Tax-positive ATLL cells were young cells derived from ATLL stem cells. …”
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    Development of Ultra-Super Sensitive Immunohistochemistry and Its Application to the Etiological Study of Adult T-Cell Leukemia/Lymphoma
  7. 51867
    “…PURPOSE: Recently, we reported finding that circulating melatonin levels in age-related macular degeneration patients were significantly lower than those in age-matched controls. …”
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    Effects of melatonin and its receptor antagonist on retinal pigment epithelial cells against hydrogen peroxide damage
  8. 51868
    por Thumann, Gabriele
    Publicado 2012
    “…To the second group belong glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR). …”
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    Prospectives for Gene Therapy of Retinal Degenerations
  9. 51869
    “…Of notice, taken the whole TC group, family history of thyroid disease positively correlated with capsular invasion (P = 0.025). CONCLUSIONS: Older age is manifold associated with unfavorable tumor markers in our series. …”
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    BRAF mutations in thyroid tumors from an ethnically diverse group
  10. 51870
    “…Case 4 was a 24-year-old Caucasian man with a macular haemorrhage after thoracic trauma. He was observed over four weeks, after which we performed 23G pars plana vitrectomy, with complete visual restoration (visual acuity:1.0). …”
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    Long-term evolution of Valsalva retinopathy: a case series
  11. 51871
    “…This provides molecular and cellular evidence of the validity of curcumin supplementation as a therapeutic strategy for the suppression of age-related macular degeneration (AMD)-associated CNV.…”
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    Suppression of Experimental Choroidal Neovascularization by Curcumin in Mice
  12. 51872
    “…PURPOSE: Age-related macular degeneration (AMD) is a local, chronic inflammatory disease of the eye that is influenced by oxidative stress and dysregulation of the retinal pigment epithelium (RPE) associated with aging. …”
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    Altered cytokine profiles of human retinal pigment epithelium: Oxidant injury and replicative senescence
  13. 51873
    por Jellinger, Kurt A.
    Publicado 2013
    “…Major types of sporadic VaD are multi-infarct encephalopathy, small vessel and strategic infarct type dementias, subcortical arteriosclerotic leukoencephalopathy (SAE) (Binswanger), multilacunar state, mixed cortico-subcortical type, granular cortical atrophy (rare), postischemic encephalopathy, and a mixture of cerebrovascular lesions (CVLs). …”
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    Pathology and pathogenesis of vascular cognitive impairment—a critical update
  14. 51874
    “…The CCL2/CX3CR1 deficient mouse may thus serve as a model for age-related atrophic degeneration of the RPE, including the dry type of macular degeneration, geographic atrophy.…”
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    Age- and Light-Dependent Development of Localised Retinal Atrophy in CCL2(−/−)CX3CR1(GFP/GFP) Mice
  15. 51875
    “…RESULTS: The genome of Sii CJ18 harbors several unique regions in comparison to Sii ATCC BAA-102(T), among others an enlarged exo- and capsular polysaccharide operon; Streptococcus thermophilus-associated genes; a region containing metabolic and hypothetical genes mostly unique to CJ18 and the dairy isolate Streptococcus gallolyticus subsp. macedonicus; and a second oligopeptide transport operon. …”
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    Comparative genome analysis of Streptococcus infantarius subsp. infantarius CJ18, an African fermented camel milk isolate with adaptations to dairy environment
  16. 51876
    “…There was a strong positive correlation between maternal-specific and infant-specific antibodies’ responses against pertussis (r(s)=0.71, p<0.001), Hib (r(s)=0.80, p<0.001), tetanus (r(s)=0.90, p<0.001) and pneumococcal capsular polysaccharide (r(s)=0.85, p<0.001). Only 30% (33/109) and 42% (46/109) of infants showed a protective antibody response to pertussis and Hib, respectively. …”
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    Specific antibodies against vaccine-preventable infections: a mother–infant cohort study
  17. 51877
    “…METHODOLOGY/PRINCIPAL FINDINGS: The NOMV-fHbp vaccine was prepared from a mutant African MenW strain with PorA P1.5,2, attenuated endotoxin (ΔLpxL1), deleted capsular genes, and over-expressed fHbp in variant group 1. …”
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    Mutant Native Outer Membrane Vesicles Combined with a Serogroup A Polysaccharide Conjugate Vaccine for Prevention of Meningococcal Epidemics in Africa
  18. 51878
    “…To investigate the frequency of creatine inclusions within the hippocampal formation as well as in its selected areas (sectors 1–3 of Ammon’s horn (CA1–CA3), dentate gyrus (DG), and hilus of DG) and cellular layers (pyramidal, molecular, multiform, and granular cell layers), synchrotron radiation-based Fourier-transform infrared microspectroscopy was used. …”
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    Differences in the hippocampal frequency of creatine inclusions between the acute and latent phases of pilocarpine model defined using synchrotron radiation-based FTIR microspectroscopy
  19. 51879
    “…Of the 24 patients, 89% had macular lesions, with a median time (interquartile range) to development of 1.2 (0.8–2.2) years following treatment. …”
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    Post Kala-Azar Dermal Leishmaniasis following Treatment with 20 mg/kg Liposomal Amphotericin B (Ambisome) for Primary Visceral Leishmaniasis in Bihar, India
  20. 51880
    “…PURPOSE: Oxidant- and inflammation-induced damage to retinal pigment epithelial (RPE) cells is central to the pathogenesis of age-related macular degeneration (AMD). Thus, developing novel strategies to protect these cells is important. …”
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    L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium
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