“…Genetic factors relate to corin remain unclear. The purpose of the current study was to comprehensively examine the associations among CORIN SNPs, methylations, serum corin levels and hypertension. …”
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“…Corin deficiency impairs fecal sodium excretion in mice. …”
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“…It has been well documented that corin is a critical protease involved in the regulation of blood pressure and cardiac function. …”
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“…The study aimed to determine whether corin may be a predictor of PE in a high-risk group—women with long-term PGDM. …”
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“…In corin-deficient mice on normal- and high-salt diets, sweat and salt excretion is reduced. …”
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“…The objective of this publication is to evaluate the results of TAA in a series of patients treated with corin system total ankle replacement METHODS: 26 TAA were implanted from Jan / 13 to Aug / 16, (26 patients - 15F: 58% / 11M: 42%) (mean age: 55 years: min 37a / max 69a) using the implants Zennith from Corin (UK). …”
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“…We created corin conditional knockout (cKO), in which the Corin gene was selectively disrupted in the kidney (kcKO) or heart (hcKO). …”
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“…INTRODUCTION: Corin is a protease in the natriuretic peptide system. …”
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“…Corin is a protease that activates atrial natriuretic peptide, a cardiac hormone important in the control of blood pressure and salt-water balance. …”
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“…It remains unknown if corin has a role in regulating adipose tissue function. …”
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“…Activated corin cleaves pro-ANP to ANP, which regulates water–sodium balance and lowers blood pressure. …”
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“…BACKGROUND: Corin is a transmembrane protease that activates ANP and BNP (atrial and B‐type natriuretic peptides). …”
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“…Corin deficiency prevents ANP activation and causes hypertension and heart disease. …”
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“…Altered expression of corin, a cardiac transmembrane serine protease, has been linked to dilated and ischemic cardiomyopathy. …”
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“…RESULTS: The final diagnostic model included age, sex, cigarette smoking, family history of stroke, history of hypertension, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, fasting glucose, and serum corin. The diagnostic model exhibited good discrimination in both training (AUC: 0.910, 95% CI: 0.884–0.936) and testing (AUC: 0.907, 95% CI: 0.881–0.934) samples. …”
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“…In conclusion, acute myocardial infarction induces rapid increases in plasma corin and decreases in cardiac corin levels. In the early phase of acute myocardial infarction, plasma corin levels are inversely correlated with heart function and may reflect the severity of myocardial damage.…”
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“…MicroRNAs (miRNAs) are pervasive regulators of gene expression, but their potential role in regulating corin activity has not been elucidated. Our aim was to systematically identify and characterize miRNA regulators of corin activity in human cardiomyocytes. …”
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“…INTRODUCTION: Proprotein convertase subtilisin/kexin-6 (PCSK6) is a secretory protein that activates corin in the heart. Higher circulating levels of corin are associated with improved cardiovascular outcomes in patients with acute myocardial infarction. …”
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