“…A simple and efficient synthesis of novel, D-ring substituted estrone derivatives containing a 16α-triazolyl moiety is described. Two epimeric azido alcohols (16α-azido-17α-hydroxy and 16α-azido-17β-hydroxy) of estra-1,3,5(10)-triene-3-methyl ether were prepared, followed by copper(I)-catalyzed azide-alkyne cycloaddition with various terminal alkynes. …”
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“…The stereochemical configurations of 3-O-benzyl-1,2-O-iso­propyl­idene-5-O-methane­sulfonyl-6-O-tri­phenyl­methyl-α-d-gluco­furan­ose, C(36)H(38)O(8)S (3) [systematic name: 1-[(3aR,5R,6S,6aR)-6-benz­yloxy-2,2-di­methyl­tetra­hydro­furo[2,3-d][1,3]dioxol-5-yl)-2-(trit­yloxy)ethyl methane­sulfonate], a stable inter­mediate, and 5-azido-3-O-benzyl-5-de­oxy-1,2-O-iso­propyl­idene-6-O-tri­phenyl­methyl-β-l-ido­furan­ose, C(35)H(35)N(3)O(5) (4) [systematic name: (3aR,5S,6S,6aR)-5-[1-azido-2-(trit­yloxy)eth­yl]-6-benz­yloxy-2,2-di­methyl­tetra­hydro­furo[2,3-d][1,3]dioxole], a substitution product, were examined and the inversion of configuration for the azido group on C-5 in 4 was confirmed. …”
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“…This unique mechanism increases selectivity against AZT incorporation by allowing reversal of the reaction and release of substrate, thereby reducing k(cat)/K(m) (7 × 10(−6) μ M(−1) s(−1)). Other azido-nucleotides (AZG, AZC and AZA) and 8-oxo-7,8-dihydroguanosine-5′-triphosphate (8-oxo-dGTP) show this same phenomena.…”
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“…This article reports on an empirical study in which data-driven learning was accomplished with the assistance of the user-friendly BNCweb, and presents the evaluation of the outcome by comparing the effectiveness of BNCweb and a search engine Baidu which is most commonly used as reference resource by Chinese learners of English as a foreign language. …”
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“…New redox labelling of DNA by an azido group which can be chemically transformed to nitrophenyltriazole or silenced to phenyltriazole was developed and applied to the electrochemical detection of DNA–protein interactions. 5-(4-Azidophenyl)-2′-deoxycytidine and 7-(4-azidophenyl)-7-deaza-2′-deoxyadenosine nucleosides were prepared by aqueous-phase Suzuki cross-coupling and converted to nucleoside triphosphates (dNTPs) which served as substrates for incorporation into DNA by DNA polymerase. …”
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“…First, the t-Bu-P(4)-catalyzed ROP of decyl glycidyl ether, dec-9-enyl glycidyl ether, and 2-(2-(2-methoxyethoxy) ethoxy) ethyl glycidyl ether with the aid of functional initiators and terminators was employed for the preparation of a clickable linear triblock terpolymer precursor possessing three azido and three ethynyl groups at the selected positions. …”
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