“…While a variety of methods have been established to introduce the azido group into recombinant proteins, a method that directly converts specific amino groups in endogenous proteins is lacking. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Herein we present a previously unexplored and divergent route towards ‘click’ neoglycoprotein analogues of EPO, employing one-pot native chemical ligation (NCL) of alkynylated peptides and copper-catalysed azide–alkyne cycloaddition (CuAAC) with azido monosaccharides. By design, our synthetic platform permits glycosylation at virtually any stage, providing flexibility for the synthesis of various glycoforms for biological analysis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although less well-explored, inorganic Pt-click reactions enable synthesis of novel (potentially multimetallic) Pt complexes and provide plausible routes to introduce functional groups and monitoring Pt-azido drug localisation.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Perfluorobutyl and perfluorooctyl moieties were attached through linkers of different length to azido derivatives of vancomycin aglycone and teicoplanin pseudoaglycone, and the new derivatives were evaluated against a diverse panel of viruses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this paper, we predict the epidemic risk of each province based on geographical proximity information, spatial inverse distance information, economic distance and Baidu migration index. A simulation study revealed that the information based on geographical economy matrix and migration index could well predict the spatial spread of the epidemic. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An azido-derivative of a fluorescein bifluorophore was obtained and used for the synthesis of “molecular beacon”-type oligonucleotide fluorogenic probes for RT-PCR. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Most of the substitution reactions of the hydroxyl group to azido group proceeded with net retention of the configuration and involved actual aziridine or plausible aziridinium ion intermediates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thereby amino, diazonio, bromo, azido and iodo rhodocenium salts containing valuable functional groups are accessible for the first time. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To avoid potential endogenous problems, we exploit the bilateral population flow from the Baidu Migration Index to predict prefectures' probability to undertake lockdown measures. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To circumvent this limitation, we report herein a more direct approach combining cell metabolism of azido-sugar and bio-orthogonal click chemistry to conjugate at the cell glycocalyx structurally well-defined glycodendrimers as antibody binding module (ABM). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Complementary reactions of simple alkynes with azido-substituted peroxides are much less efficient. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The synthesis of five new multivalent derivatives of a trihydroxypiperidine iminosugar was accomplished through copper catalyzed alkyne‐azide cycloaddition (CuAAC) reaction of an azido ending piperidine and several propargylated scaffolds. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Despite the low yields, this approach to sulfonyl-substituted tetrahydroisoquinolines appears practical as alternative syntheses based on the traditional, carboxylic acid CCR adducts would presumably be cumbersome and multistep. The azido- and nitro-substituted o-methyl benzoic acids failed to react with imines.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A series of novel 1-N-α-d-glucopyranosyl-1H-1,2,3-triazole xanthines was synthesized from azido sugars (glucose, galactose, and lactose) and propargyl xanthines (theophylline and theobromine) using a typical copper (I)-catalyzed azide–alkyne 1,3-dipolar cycloaddition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The monthly Baidu index was significantly correlated with cancer mortality rates for 24 of 27 cancers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Complete separation of [(18)F]FPyKYNE from its nitro precursor and [(18)F]fluoropyridine–candesartan from the deprotected azido-candesartan allowed for high molar activities (>380 GBq/μmol) of the tracer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…FUNDAMENTO: Tendo em vista os casos de lactentes sintomáticos com Tetralogia de Fallot (TF), baixo peso ao nascimento e anatomia complexa, o implante de stent na via de saída do ventrículo direito (VSVD) tem sido indicado alternativamente à cirurgia de Blalock-Taussig (BT). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: The panel data of 237 Chinese cities were extracted with local officials’ characteristics, confirmed cases, Baidu migration index, Baidu search index according to city names, and data were excluded with local officials’ relocation or sub-provincial cities between January 1, 2020 and May 5, 2020. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Ongoing clinical trial databases will also be searched for studies published from the time of establishment of each database to September 1, 2022. that will include the Chinese Clinical Trial Registration Centre (www.chictr.org.cn/), the World Health Organisation International Trial Registration Platform (https://www.who.int/clinical-trials-registry-platform), Google Scholar (https://scholar.google.com/), Baidu Scholar (https://xueshu.baidu.com), etc. The main outcome indicators included urinary albumin excretion rate or 24-hour urinary albumin excretion rate, and renal function (blood urea nitrogen, serum creatinine concentration). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Kennedy (1963); el momento en que el primer ser humano pisó la Luna (1969); el instante en que explotó el transbordador espacial Challenger (1986); la masacre de la Plaza en Tiananmen (1989); la caída del muro de Berlín (1989); los atentados del 11 de septiembre a las Torres Gemelas de Nueva York (2001); el terremoto y el tsunami de Japón (2011); las marchas de protesta por la desaparición forzada de los 43 estudiantes normalistas de Ayotzinapa, Guerrero (2014) y los atentados de París (2015), entre otros acontecimientos que han estremecido, asombrado e indignado a la sociedad.…”
Enlace del recurso
Enlace del recurso