“…The current work aimed to use a self-contingent strategy which overcomes previous synthetic limitations to produce neoglycolipids that have one exposed mannose residue, an aromatic scaffold, and two lipid tails with varied alkyl chains. The azido-ending carbohydrates and the carboxylic acid-ending lipid tails were ligated using a new one-pot modified Staudinger chemistry that differed advantageously to previous syntheses. …”
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“…The reactive non-canonical amino acid azidolysine (AzK) was inserted at predefined single positions in both proteins. The azido groups were functionalized by bioorthogonal conjugation with individual linkers that facilitated selective coupling via an alternative bioorthogonal click chemistry reaction. …”
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“…Não indica necessariamente um baixo risco de taquicardia supraventricular. Deve ser reconhecido na triagem de ECG e distinguido de outras patologias que também apresentam QRS alternantes.…”
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“…Também foi observado que baixos níveis de MOTS-C podem ser um importante marcador prognóstico e podem ter um papel na patogênese do IAMCSST.…”
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“…FUNDAMENTO: O comportamento sedentário tem sido associado a diversos fatores de risco cardiometabólicos durante a infância. …”
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“…RESULTS: The mean score for the content quality of English websites was significantly higher than that of Chinese websites (6.16 vs 4.94, P=.03 for Google, Bing, and Yahoo; 6.16 vs 4.16, P<.001 for Baidu, Sougou, and Bing China). Chinese users who are not influenced by the Internet Censorship System are more likely to access higher-quality online medical information (4.94 vs 4.16, P=.02). …”
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“…FUNDAMENTO: Existem dados limitados sobre a evolução clínica de lesões coronarianas não tratadas de acordo com sua gravidade funcional no mundo real. …”
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“…Isolated purified plasma membrane domains from unstimulated human neutrophils were photoaffinity labeled with F-Met-Leu-Phe-N epsilon-(2- (p-azido-[125I]salicylamido)ethyl- 1,3'-dithiopropionyl)-Lys also referred to as FMLPL-SASD[125I]. …”
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“…The statistical models to predict the probability of user’s future visit to a medical facility were built using effective predictors of health care resource utilization, extracted from a deidentified dataset of geotagged mobile Internet search logs representing searches made by users of the Baidu search engine between March 2015 and May 2015. …”
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“…We showed tourists in the Turks Caicos Islands (N = 292) images of a marine mammal park (MMP) killer whale show and a swim-with-the-dolphins (SWTD) attraction and asked for their qualitative comments on the potential development of each. …”
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“…[Image: see text] A series of dinuclear octahedral Pt(IV) complexes trans,trans,trans-[{Pt(N(3))(2)(py)(2)(OH)(OC(O)CH(2)CH(2)C(O)NH)}(2)R] containing pyridine (py) and bridging dicarboxylate [R = −CH(2)CH(2)– (1), trans-1,2-C(6)H(10)– (2), p-C(6)H(4)– (3), −CH(2)CH(2)CH(2)CH(2)– (4)] ligands have been synthesized and characterized, including the X-ray crystal structures of complexes 1·2MeOH and 4, the first photoactivatable dinuclear Pt(IV) complexes with azido ligands. The complexes are highly stable in the dark, but upon photoactivation with blue light (420 nm), they release the bridging ligand and mononuclear photoproducts. …”
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“…UGT2B10 and UGT2B7 activities were probed using nicotine and 3′-azido-3′-deoxythymidine, respectively, and significant decreases in glucuronidation activity were observed for both substrates in HuH-7 and Hep3B cells upon overexpression of miR-485-5p mimic. …”
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“…Historical and near-real time human movement data, obtained from Baidu location-based service, were used to derive the intensity of travel restrictions and contact reductions across China. …”
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“…Further, (2) at both levels, the significant hotspots and cluster/outlier areas were observed solely in Wuhan city and most of its districts/sub-cities from 30 January to 18 February 2020. (3) At the prefecture level in Hubei province, the number of CCC had a positive and extremely significant correlation (p < 0.01) with the registered population (RGP), resident population (RSP), Baidu migration index (BMI), regional gross domestic production (GDP), and total retail sales of consumer goods (TRS), respectively, from 29 January to 18 February 2020 and had a negative and significant correlation (p < 0.05) with minimum elevation (MINE) from 2 February to 18 February 2020, but no association with the land area (LA), population density (PD), maximum elevation (MAXE), mean elevation (MNE), and range of elevation (RAE) from 23 January to 18 February 2020. (4) At the county level, the number of CCC in Hubei province had a positive and extremely significant correlation (p < 0.01) with PD, RGP, RSP, GDP, and TRS, respectively, from 27 January to 18 February 2020, and was negatively associated with MINE, MAXE, MNE, and RAE, respectively, from 26 January to 18 February 2020, and negatively associated with LA from 30 January to 18 February 2020. …”
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“…However, its Natural Heritage status has been threatened by the construction and operation of the Baixo Iguaçu dam, agricultural and urban impacts on its boundaries and the increasing interest of the Brazilian government in re-opening of the “Colono road”, an old illegal road that crossed the interior of the park. …”
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“…While Ba(2)In(2)O(5) (BaInO(2.5)) crystallizes in an ordered brownmillerite structure, Ibm2, and Ba(2)Fe(2)O(5) (BaFeO(2.5)) crystallizes in a complex monoclinic structure, P2(1)/c, showing seven Fe(3+) sites with tetrahedral, square planar, and octahedral environments, all phases studied here crystallize in the cubic perovskite structure, Pm3̅m, with long-range disorder on the small cation and oxygen sites. (57)Fe Mössbauer studies indicate a mixed valency, Fe(4+)/Fe(3+), for both the air-fired and argon-fired samples. …”
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“…A decrease in involuntary hospitalizations was associated with being married/cohabitating [exp([Formula: see text] ) = 0.74; 95%CI 0.56–0.99, p < 0.05], having experienced a suicide attempt [exp([Formula: see text] ) = 0.26; 95%CI 0.15–0.42, p < 0.001], and belonging to the catchment area of three of the psychiatric services evaluated [exp([Formula: see text] ) = 0.65; 95%CI 0.49–0.86, p < 0.01, exp([Formula: see text] ) = 0.67; 95%CI 0.49–0.90, p < 0.01, and exp([Formula: see text] ) = 0.67; 95%CI 0.46–0.96, p < 0.05 for Hospital de Magalhães Lemos, Centro Hospitalar Psiquiátrico de Lisboa and Unidade Local de Saúde do Baixo Alentejo, respectively]. CONCLUSIONS: The findings suggest that involuntary psychiatric hospitalizations in Portugal are associated with several sociodemographic, clinical, and contextual factors. …”
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“…RESULTADOS: O ECC foi significativamente mais baixo em pacientes com doença de Chagas em comparação aos controles (p<0,05). …”
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“…CONCLUSÕES: Fumantes com baixo nível de atividade física habitual apresentaram baixa qualidade do sono e alterações na modulação do sistema nervoso autônomo. …”
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“…Os preditores que mais contribuíram para o cálculo nas faixas de baixo (1,88% [1,42-2,67]), médio (5,17% [4,89-5,70]) e alto risco (7,82% [7,06-9,19]) foram espessura parietal máxima do ventrículo esquerdo (1,60% [1,25-2,02] ; 3,20% [3,18-3,36] ; 4,46% [4,07-5,09]), diâmetro do átrio esquerdo (0,97% [0,83-1,21]; 1,86% [1,67-2,40]; 2,48% [2,21-3,51]) e idade (-0,91% [0,8-1,13]; -1,90% [1,12-2,03]; -2,34% [1,49-2,73]). …”
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