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  1. 5061
    “…Collectively, our results reveal the importance of dissecting target site selection mechanisms and highlight new opportunities to leverage CAST systems for accurate, kilobase-scale genome engineering applications.…”
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    Mechanism of target site selection by type V-K CRISPR-associated transposases
  2. 5062
    “…The mean abundance of ARGs, in units of log(10) ARG fragments per kilobase per million mapped reads classified as bacteria, was highest in Africa compared with Europe (p=0·014), North America (p=0·0032), and the Western Pacific (p=0·011), and second highest in South-East Asia compared with Europe (p=0·047) and North America (p=0·014). …”
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    Evaluating the relationship between community water and sanitation access and the global burden of antibiotic resistance: an ecological study
  3. 5063
    “…In USA300-MRSA 2658 chromosomal open reading frames were predicted and 3.1 and 27 kilobase (kb) plasmids were identified. USA300-MSSA contained a 20 kb plasmid with some homology to the 27 kb plasmid found in USA300-MRSA. …”
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    Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus
  4. 5064
    “…Using a higher resolution polymerase chain reaction (PCR)-amplicon microarray spanning the neocentromere, we find that the CENP-A chromatin is discontinuous, consisting of a major domain of about 87.8 kilobases (kb) and a minor domain of about 13.2 kb, separated by an approximately 158 kb region devoid of CENPs. …”
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    Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres
  5. 5065
    “…RESULTS: We mapped 1,755 single nucleotide polymorphism (SNP) markers from bacterial artificial chromosome (BAC) end sequences onto 28 linkage groups using a recombining male backcross population, yielding an average inter-SNP distance of 0.81 cM (about 270 kilobases). We constructed 6,221 contigs by fingerprinting clones from three BAC libraries digested with different restriction enzymes, and assigned a total of 724 single copy genes to them by BLAST (basic local alignment search tool) search of the BAC end sequences and high-density BAC filter hybridization using expressed sequence tags as probes. …”
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    A BAC-based integrated linkage map of the silkworm Bombyx mori
  6. 5066
    “…RESULTS: The 2,739,625 base pair chromosome of OG1RF was found to contain approximately 232 kilobases unique to this strain compared to V583, the only publicly available sequenced strain. …”
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    Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
  7. 5067
    “…BACKGROUND: Macrosatellite repeats (MSRs), usually spanning hundreds of kilobases of genomic DNA, comprise a significant proportion of the human genome. …”
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    Online Artículo Texto
    Genome-wide analysis of macrosatellite repeat copy number variation in worldwide populations: evidence for differences and commonalities in size distributions and size restrictions
  8. 5068
    “…RESULTS: Among transcriptome data we found thousands of instances, in which reads mapped onto genomic loci not annotated as genes, some reaching up to several kilobases in length. At first sight these appear to represent long non-coding RNAs (lncRNAs), however, about half of these lncRNAs have significant sequence similarities to genomic loci annotated as protein-coding genes. …”
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    The parasite Trichomonas vaginalis expresses thousands of pseudogenes and long non-coding RNAs independently from functional neighbouring genes
  9. 5069
    “…Data presented herein localize Renag1 to a 379 kilobase (kb) interval that contains a single protein coding gene, Kit (v-kit Hardy-Zukerman 4 feline sarcoma viral oncogene homolog); identify an endogenous retrovirus-derived long terminal repeat located within Kit intron 1 as the probable causal variant; demonstrate aberrant development of the nephric duct in the anticipated number of ACI rat embryos; and demonstrate expression of Kit and Kit ligand (Kitlg) in the nephric duct. …”
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    Genetic Etiology of Renal Agenesis: Fine Mapping of Renag1 and Identification of Kit as the Candidate Functional Gene
  10. 5070
    “…Identified variants were filtered for those that were: located in the linked interval on chromosome 10q23-q24; novel or rare (minor allele frequency ≤0.01); heterozygous; present in all affected individuals and not in controls; and present in genes that encode proteins expressed in human corneal epithelial cells (reads per kilobase per million ≥1). Sanger sequencing of identified variants (SNVs) was performed in additional family members. …”
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    Whole Exome Sequencing and Segregation Analysis Confirms That a Mutation in COL17A1 Is the Cause of Epithelial Recurrent Erosion Dystrophy in a Large Dominant Pedigree Previously Mapped to Chromosome 10q23-q24
  11. 5071
    por Murk, William, DeWan, Andrew T.
    Publicado 2016
    “…This interaction was notable in that rs910652 is located within 78 kilobases of ADAM33, which is one of the most well studied asthma susceptibility genes. …”
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    Genome-wide search identifies a gene-gene interaction between 20p13 and 2q14 in asthma
  12. 5072
    “…METHODS: We investigate twelve putative larval habitats (habitat types) of Culicoides inside and outside of three horse farms in the Niayes area of Senegal using a combination of flotation and emergence methods during four collection sessions. …”
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    Insight on the larval habitat of Afrotropical Culicoides Latreille (Diptera: Ceratopogonidae) in the Niayes area of Senegal, West Africa
  13. 5073
    “…RESULTS: A region of high linkage disequilibrium spanning over 170 kilobases (kb) was identified with both NGS and laboratory determined microsatellite alleles. …”
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    Exceptionally long-range haplotypes in Plasmodium falciparum chromosome 6 maintained in an endemic African population
  14. 5074
    “…Usually, vertebrate mitochondrial genomes measure between 16.5 and 17 kilobases (kb). RESULTS: During genome sequencing projects for two novel vertebrate models, the invasive round goby and the sand goby, we found that the sand goby genome is exceptionally small (16.4 kb), while the mitochondrial genome of the round goby is much larger than expected for a vertebrate. …”
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    The mitochondrial genome sequences of the round goby and the sand goby reveal patterns of recent evolution in gobiid fish
  15. 5075
    “…In addition, targeted genes for 10 lincRNAs with the highest fragments per kilobase of transcript per million fragments mapped (FPKM) were predicted by LncTar for forecasting potential biological functions of these lincRNAs. …”
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    Identification and characterization of long intergenic noncoding RNAs in bovine mammary glands
  16. 5076
    “…Fecal samples were analyzed by the flotation method to estimate the reduction in the fecal egg counts (FECR), the percentage of horses shedding eggs (PHR), and the egg reappearance period (ERP). …”
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    A combined effort to avoid strongyle infection in horses in an oceanic climate region: rotational grazing and parasiticidal fungi
  17. 5077
    “…METHODS: Fecal samples from 573 dogs originating from four populations (household dogs, shelter dogs, hunting dogs and clinical dogs) were examined with centrifugation sedimentation flotation (CSF) coproscopical analysis, direct immunofluorescence assay (DFA, Merifluor Cryptosporidium/Giardia®), a rapid enzyme immunochromatographic assay (IDEXX SNAP Giardia®) and qPCR (SSU rDNA) for presence of G. duodenalis. …”
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    Comparing four diagnostic tests for Giardia duodenalis in dogs using latent class analysis
  18. 5078
    “…Significant differences in transcripts per kilobase million (TPM) were determined using (i) genes for which the expression difference between treatments was higher than 99% of that in the random case (P < 0.01), and (ii) genes for which the fold change was ≥ 2, to avoid expression bias in selection of the candidate genes. …”
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    Transcriptome analysis reveals that fertilization with cryopreserved sperm downregulates genes relevant for early embryo development in the horse
  19. 5079
    “…To address this gap in knowledge, we examined sequence variation across ~ 10 kilobases (kbs), encompassing LTα and the upstream region, in 2039 individuals from the 1000 Genomes Project originating from 21 global populations. …”
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    Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6
  20. 5080
    “…A subset of cats exhibiting signs of upper respiratory disease or diarrhea had been tested for infections by PCR and fecal flotation for treatment planning. Mycoplasma felis (78%), calicivirus (78%), and Streptococcus equi subspecies zooepidemicus (55%) were the most common respiratory infections. …”
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    Infectious diseases in large-scale cat hoarding investigations
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