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26461por Wang, Laidi, Liang, Wenshuang, Wang, Shasha, Wang, Zhixiu, Bai, Hao, Jiang, Yong, Bi, Yulin, Chen, Guohong, Chang, Guobin“…There were four corresponding miRNAs for circ-PLXNA1 and 313 target genes for those miRNAs. CeRNA“circ-PLXNA1/miR-214/CTNNB1 axis” was focused and verified by a dual-luciferase reporter experiment. …”
Publicado 2020
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26462“…In the present study, differentially expressed transcripts in pancreatic cancer (PC) were identified, and a competing endogenous RNA (ceRNA) network was constructed using The Cancer Genome Atlas database. …”
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26463por Wu, Hong-Kun, Liu, Chang, Li, Xin-Xing, Ji, Wei, Xin, Chen-De, Hu, Zhi-Qian, Zhou, Lin“…Conjointly, our results demonstrated the suppressive effects of PHLPP2 in colon cancer and proved that LINC00402, LINC00461, and SFTA1P acted as ceRNAs of PHLPP2 by competitive binding to miR-141 and miR-424.…”
Publicado 2020
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26464por Chen, Xiao, Wang, Jie, Xie, Fei, Mou, Tinggang, Zhong, Pingyong, Hua, Hao, Liu, Pan, Yang, Qin“…Meanwhile, LINC01559 could act as a ceRNA to competitively sponge miR-1343-3p to up-regulate RAF1 and activate its downstream ERK pathway Conclusions: LINC01559 functions as an oncogene in PC progression through acting as a ceRNA of miR-1343-3p. …”
Publicado 2020
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26465por Yu, Min, Tian, Yingxuan, Wu, Min, Gao, Jinglong, Wang, Yuan, Liu, Fuqiang, Sheng, Sen, Huo, Shufen, Bai, Jun“…Afterwards, miRNA–DEcircRNA pairs and miRNA–DEmRNA pairs were predicted to construct a competing endogenous RNAs (ceRNAs) network, followed by functional enrichment analysis and survival analysis. …”
Publicado 2020
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26466“…Competing endogenous RNA (ceRNA) networks were constructed on the basis of genes in the MAPK signaling pathway. …”
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26467por Xie, Hui, Zhao, Jiabin, Wan, Jiahui, Zhao, Jianing, Wang, Qianqian, Yang, Xu, Yang, Weiyu, Lin, Ping, Yu, Xiaoguang“…Overall, the present study proposed a novel model in which the AC245100.4/miR-145-5p/RBBP5 ceRNA network induced the development of PCa, providing novel insights for PCa treatment.…”
Publicado 2021
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26468“…However, MEG3 could directly bind to miR-19a and effectively act as a competing endogenous RNA (ceRNA) for miR-19a to suppress tumorigenesis. Our study is the first to demonstrate that lncRNA MEG3 suppresses glioma cell proliferation, migration, and invasion by acting as a ceRNA of miR-19a, which provides a novel insight about the pathogenesis of glioma.…”
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26469“…CONCLUSIONS: The findings reveal for the first time that linc01184 is an enhancer for the proliferation and invasion of CRC by functioning as a ceRNA through the linc01184-miR-331-HER2-p-Akt/ERK1/2 pathway regulatory network.…”
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26470por Chen, Yu-Xiao, Ding, Jie, Zhou, Wei-Er, Zhang, Xuan, Sun, Xiao-Tong, Wang, Xi-Ying, Zhang, Chi, Li, Ni, Shao, Guo-Feng, Hu, Shen-Jiang, Yang, Jian“…As a possible mechanism of DCM pathogenesis, we predicted that these hub lncRNAs might exert functions by acting as competing endogenous RNAs (ceRNAs). Furthermore, we found that the above results can be essentially reproduced in an independent external dataset. …”
Publicado 2021
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26471por Yu, Seong-Lan, Kim, Tae-Hyun, Han, Young-Hyun, Kang, Yujin, Jeong, Da-Un, Lee, Dong Chul, Kang, Jaeku, Park, Seok-Rae“…From the differentially expressed lncRNA/miRNA/mRNA ceRNA network, hub RNAs that formed three axes were identified: The DLX6-AS1/miR-141 or miR-200a/OLFM1 axis, the WDFY3-AS2/miR-135a or miR-183/STC1 axis, and the LINC00240/miR-182/NDRG1 axis. …”
Publicado 2021
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26472por Wu, Xiao-Yan, Xie, Yi, Zhou, Li-Yun, Zhao, Yuan-Yuan, Zhang, Jing, Zhang, Xiu-Feng, Guo, Shuai, Yu, Xue-Yan“…Collectively, POU6F2-AS1 might function as a ceRNA through sponging miR-34c-5p to high-regulate KCNJ4 in LADC, which indicates that POU6F2-AS1 might be a promising therapeutic target with significant prognostic value for LADC treatment.…”
Publicado 2021
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26473por Kong, Fancong, Lv, Zhanyun, Wang, Lifang, Zhang, Kui, Cai, Ying, Ding, Qingqing, Sun, Zuzhen, Zhen, Hefu, Jiao, Fengjuan, Ma, Qianqian, Nie, Chao, Yang, Yan“…In addition, we correlated mRNAs and circRNAs by constructing a competing endogenous RNA (ceRNA) network in PD. The resulted-in ceRNA network included 10 differentially expressed mRNAs from PD pathway, 13 predicted miRNAs, and 10 differentially expressed circRNAs. …”
Publicado 2021
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26474por Zong, Guangxin, Feng, Xinrong, Sun, Xiuhua, Du, Jiexin, Wang, Guangsheng, Song, Tingting“…LncRNA MALAT1 upregulates HMGA1 expression by acting as a competitive endogenous RNA (ceRNA) for miR-125b. Rescue experiments showed that microRNA-125b inhibitor reversed the change in cell viability and invasion induced by sh-MALAT1. …”
Publicado 2021
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26475por Zang, Xupeng, Gu, Ting, Wang, Wenjing, Zhou, Chen, Ding, Yue, Gu, Shengchen, Xu, Zhiqian, Xie, Yanshe, Li, Zicong, Cai, Gengyuan, Hu, Bin, Hong, Linjun, Wu, Zhenfang“…In addition, Blast analysis showed the applicability of the constructed ceRNA network in different species, and subsequently determined HOXA-AS2 in pigs. …”
Publicado 2021
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26476por Wang, Hanbang, Zhu, Yakun, Cao, Le, Guo, Ziming, Sun, Kai, Qiu, Wangbao, Fan, Haitao“…The competing endogenous RNA (ceRNA) co-expression network was constructed to measure the meaningful correlated expression of differentially expressed genes. …”
Publicado 2021
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26477por Xiao, Qi, Yin, Ruihua, Wang, Yuan, Yang, Shaonan, Ma, Aijun, Pan, Xudong, Zhu, Xiaoyan“…Two ceRNA pathways involving 5 circRNAs, 2 miRNAs, and 3 mRNAs were confirmed by qRT-PCR. …”
Publicado 2021
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26478por Zhu, Rui, Li, Xiezhao, Cai, Zhiduan, Liang, Siyang, Yuan, Yaoji, Xu, Yuyu, Lai, Dehui, Zhao, Haibo, Yang, Weiqing, Bian, Jun, Liu, Leyuan, Xu, Guibin“…Concurrently, competing endogenous RNA (ceRNA) network has been suggested to play an important role in ccRCC malignancy. …”
Publicado 2021
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26479por Xiong, Jiachao, Wu, Liang, Huang, Lu, Wu, Chunyang, Liu, Zhiming, Deng, Wenqiang, Ma, Shengbiao, Zhou, Zhenhai, Yu, Honggui, Cao, Kai“…The subcellular fractionation results illustrated that FOXP4-AS1 was primarily located in the cytoplasm of ES cells. Then a ceRNA network of FOXP4-AS1 was constructed. Analysis of the ceRNA network and GSEA yielded two candidate mRNAs for FOXP4-AS1. …”
Publicado 2021
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26480por Yang, Ya-bing, Zhou, Jia-xin, Qiu, Sheng-hui, He, Jia-shuai, Pan, Jing-hua, Pan, Yun-long“…Relative verification was done based on the GEO database. Meanwhile, the ceRNA network of FRGs in the model was also performed to explore the regulatory mechanisms. …”
Publicado 2021
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