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26861por Teng, Fei, Zhang, Ju-Xiang, Chang, Qi-Meng, Wu, Xu-Bo, Tang, Wei-Guo, Wang, Jian-Fa, Feng, Jin-Feng, Zhang, Zi-Ping, Hu, Zhi-Qiu“…The competitive endogenous RNA (ceRNA) mechanism was clarified using fluorescence in situ hybridization (FISH), Western blotting, qPCR, RNA binding protein immunoprecipitation (RIP), and dual luciferase reporter analysis. …”
Publicado 2020
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26862por Liu, Songyi, Yin, Honghao, Zheng, Shuwen, Chu, Aining, Li, Yizhi, Xing, Chengzhong, Yuan, Yuan, Gong, Yuehua“…Gene Ontology and pathway enrichment analysis were performed using the DAVID database. lncRNA-TF-mRNA and ceRNA regulation networks were constructed using Cytoscape. …”
Publicado 2020
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26863“…The present study aimed to investigate the long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) mechanisms in LUAD. The receptor activity modifying protein 2-antisense RNA 1 (RAMP2-AS1) was identified using GSE113852 and GSE130779 datasets downloaded from the Gene Expression Omnibus database, and the downregulation of RAMP2-AS1 was the most significant in LUAD. …”
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26864por Barbagallo, Cristina, Caltabiano, Rosario, Broggi, Giuseppe, Russo, Andrea, Puzzo, Lidia, Avitabile, Teresio, Longo, Antonio, Reibaldi, Michele, Barbagallo, Davide, Di Pietro, Cinzia, Purrello, Michele, Ragusa, Marco“…Competitive endogenous RNA (ceRNA) networks based on RNA–RNA interactions regulate physiological and pathological processes. …”
Publicado 2020
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26865por Xi, Yang, Jing, Zhuang, Wei, Wu, Chun, Zhang, Quan, Qi, Qing, Zhou, Jiamin, Xu, Shuwen, Han“…Targeted miRNAs were predicted based on the lnCeDB database, and a ceRNA network was constructed using the Cytoscape software. …”
Publicado 2021
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26866por Zeng, Zhao‐lei, Lu, Jia‐huan, Wang, Yun, Sheng, Hui, Wang, Ying‐nan, Chen, Zhan‐hong, Wu, Qi‐nian, Zheng, Jia‐Bo, Chen, Yan‐xing, Yang, Dong‐dong, Yu, Kai, Mo, Hai‐yu, Hu, Jia‐jia, Hu, Pei‐shan, Liu, Ze‐xian, Ju, Huai‐qiang, Xu, Rui‐Hua“…LncRNA XIST promoted CRC metastasis acting as a ceRNA for miR‐125b‐2‐3p to mediate WEE1 expression. …”
Publicado 2021
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26867por Yu, JunJie, Mao, WeiPu, Sun, Si, Hu, Qiang, Wang, Can, Xu, ZhiPeng, Liu, RuiJi, Chen, SaiSai, Xu, Bin, Chen, Ming“…Besides, the lncRNA/miRNA/mRNA ceRNA network and PPI network were constructed based on weighted gene co-expression network analysis (WGCNA). …”
Publicado 2021
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26868“…Furthermore, bioinformatics analyses established a promising ceRNAs network among mRNAs, circRNAs, and miRNAs. …”
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26869“…CONCLUSION: CircWHSC1 is an independent indicator of poor prognosis in NSCLC patients, and functions as a ceRNA of miR‐296‐3p to up‐regulate AKT3, consequently promotes NSCLC cell growth and metastasis. …”
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26870“…Gene set enrichment analysis was done by GSEA. miRNA-differentially expressed gene network and ceRNA network were analyzed and graphed by the Cytoscape software. …”
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26871“…Moreover, we aimed to construct a protein-protein interaction (PPI) network for selecting genes and a ceRNA network for presenting mRNA-miRNA-lncRNA interactions. …”
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26872“…An integrative expression and survival analysis of the hub genes and CEGs demonstrated that the NR2F1-AS1–miR-146a-5p/miR-877-5p–GALNT10/ZNF532/SLC39A1/PGK1/LCO3A1/NRP2/LPCAT2/PSMA4 and CLTC ceRNA networks were linked to the prognosis of PDAC. …”
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26873“…Then, miRcode, TargetScan, miRDB, and miRTarBase databases were used to form the competing endogenous RNA (ceRNA) network. Furthermore, SPSS Modeler 18.0 was used to construct a logistic stepwise regression prediction model for CHD diagnosis based on DElncRNAs. …”
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26874“…RESULTS: An FPI scoring model reflecting the activity of the ferroptosis pathway was constructed, and a ferroptosis-associated ceRNA network was established. The findings revealed that low expression of ADAM23 and ARHGEF26-AS1 as well as high expression of miR-372-3p was associated with poor prognosis and a lower FPI score in EC patients. …”
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26875por Wang, Dongyang, Zhao, Zhengjiang, Shi, Yiru, Luo, Junyi, Chen, Ting, Xi, Qianyun, Zhang, Yongliang, Sun, Jiajie“…Dual luciferase reporter assays verified the targeting relationship of the two ceRNA networks, circEZH2-miR378b-LPL and circEZH2-miR378b-CD36. …”
Publicado 2022
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26876por Yin, Meichen, Zhai, Lingyun, Wang, Jianzhang, Yu, Qin, Li, Tiantian, Xu, Xinxin, Guo, Xinyue, Mao, Xinqi, Zhou, Jianwei, Zhang, Xinmei“…In conclusion, this is the first study to illustrate ceRNA composed of differentially expressed circRNA, lncRNA and mRNA in endometriosis. …”
Publicado 2022
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26877“…Finally, we successfully constructed hub gene-associated TF-gene and ceRNA networks and predicted 11 drugs associated with hub genes. …”
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26878por Li, Kai, Wang, Qian, Bian, Hua, Chen, Zhiguo, He, Haifa, Zhao, Xulin, Gong, Pengju“…Through the ENCORI database and string database, we constructed the ceRNA regulatory mechanism and protein-protein interaction network for USP45. …”
Publicado 2022
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26879por Sun, Zhipeng, Hong, Qionghua, Liu, Yufang, He, Xiaoyun, Di, Ran, Wang, Xiangyu, Ren, Chunhuan, Zhang, Zijun, Chu, Mingxing“…The competing endogenous RNA (ceRNA) interaction network analysis revealed that 2,673 circRNA–miRNA–mRNA axes (including 15 DE circRNAs, 14 miRNAs, and 1,699 mRNAs) were formed, and several target genes derived from the ceRNA network were associated with oviduct functions and reproduction, including SMAD1, BMPR1B, IGF1, REV1, and BMP2K. …”
Publicado 2022
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26880“…Finally, we constructed a competitive endogenous RNA (ceRNA) network which included 67 lncRNAs, 1 miRNA (hsa-miR-320a), and 1 mRNA (NOD2). …”
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