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27201por Liu, Qiang, Zhang, Xin, Hu, Xiaoqing, Dai, Linghui, Fu, Xin, Zhang, Jiying, Ao, Yingfang“…Our results demonstrated that circRNA-CER regulated MMP13 expression by functioning as a competing endogenous RNA (ceRNA) and participated in the process of chondrocyte ECM degradation. …”
Publicado 2016
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27202por Bian, Er-Bao, Ma, Chun-Chun, He, Xiao-Jun, Wang, Chao, Zong, Gang, Wang, Hong-Liang, Zhao, Bing“…Collectively, these results suggest that epigenetic modification of miR-141 and the interaction of ceRNA regulatory network will provide a new approach for therapeutics against glioma.…”
Publicado 2016
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27203por Wang, Shou‐Hua, Zhang, Wen‐Jie, Wu, Xiao‐Cai, Weng, Ming‐Zhe, Zhang, Ming‐Di, Cai, Qiang, Zhou, Di, Wang, Jian‐Dong, Quan, Zhi‐Wei“…Real‐time quantitative PCR and Western blot analysis indicated that MALAT1 regulated Myeloid cell leukaemia‐1 (MCL‐1) expression as a competing endogenous RNA (ceRNA) for miR‐363‐3p in GBC cells. Furthermore, MALAT1 silencing decreased GBC cell proliferation and the S phase cell population and induced apoptosis in vitro. …”
Publicado 2016
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27204por Lu, Qing‐chun, Rui, Zhuang‐hua, Guo, Zhong‐liang, Xie, Wang, Shan, Shan, Ren, Tao“…Our study also indicated that mTOR was a target of miR‐496 and that DANCR could modulate the expression levels of mTOR by working as a competing endogenous RNA (ceRNA). Furthermore, the knockdown of DANCR reduced tumour volumes in vivo compared with those of the control group. …”
Publicado 2017
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27205por Vallone, Cristina, Rigon, Giuliano, Gulia, Caterina, Baffa, Alberto, Votino, Raffaella, Morosetti, Giulia, Zaami, Simona, Briganti, Vito, Catania, Francesco, Gaffi, Marco, Nucciotti, Roberto, Costantini, Fabio Massimo, Piergentili, Roberto, Putignani, Lorenza, Signore, Fabrizio“…Studies on the relation between endometrial cancer (EC) and ncRNAs, such as small ncRNAs or micro RNAs (miRNAs), transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), antisense RNAs (asRNAs), small nuclear RNAs (snRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), competing endogenous RNAs (ceRNAs), lncRNAs, and long intergenic ncRNAs (lincRNAs) have been published. …”
Publicado 2018
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27206por Yang, Dandan, Qiao, Jing, Wang, Guiying, Lan, Yuanyuan, Li, Guoping, Guo, Xudong, Xi, Jiajie, Ye, Dan, Zhu, Songcheng, Chen, Wen, Jia, Wenwen, Leng, Ye, Wan, Xiaoping, Kang, Jiuhong“…Here, we showed that the internal m(6)A modification of linc1281 mediates a competing endogenous RNA (ceRNA) model to regulate mouse ESC (mESC) differentiation. …”
Publicado 2018
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27207“…With this approach we predict time-dependent density functional theory (TDDFT) excited state energies of bacteriochlorophylls in the Fenna–Matthews–Olson (FMO) complex. Additionally we compute spectral densities and exciton populations from the predictions. …”
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27208por Rzepiela, Andrzej J, Ghosh, Souvik, Breda, Jeremie, Vina‐Vilaseca, Arnau, Syed, Afzal P, Gruber, Andreas J, Eschbach, Katja, Beisel, Christian, van Nimwegen, Erik, Zavolan, Mihaela“…By repressing the translation and promoting the degradation of target mRNAs, miRNAs may reduce the cell‐to‐cell variability in protein expression, induce correlations between target expression levels, and provide a layer through which targets can influence each other's expression as “competing RNAs” (ceRNAs). However, experimental evidence for these behaviors is limited. …”
Publicado 2018
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27209“…Further studies demonstrated that SNHG14 might serve as a competing endogenous RNA (ceRNA) by sponging miR-340 in NSCLC cells. Taken together, our study demonstrated that SNHG14/miR-340 axis might play a novel role in regulating the malignant behaviors of NSCLC, which provided a new potential diagnostic and therapeutic strategy for this malignant disease.…”
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27210por Chen, Mi, Fan, Li, Zhang, Si-Min, Li, Yong, Chen, Peng, Peng, Xin, Liu, Dong-Bo, Ma, Charlie, Zhang, Wen-Jie, Zou, Zhen-Wei, Li, Pin-Dong“…Taken together, these results suggested that LINC01939 repressed GC invasion and migration by functioning as a ceRNA for miR-17-5p to regulate EGR2 expression. …”
Publicado 2019
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27211“…Finally, we found that the radiosentizing effects of HOTAIR were related to the up-regulation of miR-218, a ceRNA of HOTAIR. In conclusion, our finding showed that HOTAIR inhibition sensitizes breast cancer cells to ionizing radiation, induced severe DNA damage and activated apoptosis pathways, suggesting a possible role of HOTAIR as a novel target for breast cancer radiosensitization.…”
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27212“…Moreover, UCA1 increases CREB1 expression by functioning as a ceRNA against miR-582, thus promoting the EMT process via CREB1-mediated PI3K/AKT/mTOR pathway and finally leading to osteosarcoma metastasis. …”
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27213por Bai, Haijing, Guo, Jianlin, Chang, Cuifang, Guo, Xueqiang, Xu, Cunshuan, Jin, Wei“…Then, the target DE lncRNAs and DE mRNAs regulated by the same miRNAs were screened and a ceRNA regulatory network containing 32 miRNAs, 107 lncRNAs, and 270 mRNAs was constructed. …”
Publicado 2019
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27214“…Moreover, we performed luciferase reporter and RNA immunoprecipitation (RIP) assay to study the competing endogenous RNA (ceRNA) function of circGFRA1 in ovarian cancer progression. …”
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27215“…We performed RNA immunoprecipitation (RIP) and luciferase assays to explore the competing endogenous RNA (ceRNA) function of circABCC2 in HCC. Results: qRT-PCR verified that circABCC2 was overexpressed in HCC. …”
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27216por Gao, Guangqi, Wang, Shenyuan, Zhang, Jiaqi, Su, Guanghua, Zheng, Zhong, Bai, Chunling, Yang, Lei, Wei, Zhuying, Wang, Xiuying, Liu, Xiao, Guo, Ziru, Li, Guangpeng, Su, Xiaohu, Zhang, Li“…Furthermore, the competing endogenous RNAs (ceRNAs) networks were identified to illustrate their roles in abnormal placental morphology. …”
Publicado 2019
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27217por Liu, Peng, Xie, Xinhua, Yang, Anli, Kong, Yanan, Allen-Gipson, Diane, Tian, Zhi, Zhou, Liye, Tang, Hailin, Xie, Xiaoming“…Also, lnc010561 and FKBP3 functioned as competing endogenous RNAs (ceRNAs) for miR-30. Our findings suggested that melatonin regulated breast cancer progression by the lnc010561/miR-30/FKBP3 axis. …”
Publicado 2019
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27218“…In this review, we discuss the mechanisms of action underlying PVT1 oncogenic role in colorectal and gastric cancer such as MYC upregulation, miRNA production, competitive endogenous RNA (ceRNA) function, protein stabilization, and epigenetic regulation. …”
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27219“…PVT1's varied activities include overexpression, modulation of miRNA expression, protein interactions, targeting of regulatory genes, formation of fusion genes, functioning as a competing endogenous RNA (ceRNA), and interactions with MYC, among many others. …”
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27220por Song, Yuanjian, Wang, Yuechen, Li, Ying, Wang, Liang, Zhang, WenDa, Cheng, Jing, Zhu, Yao, Zhang, Haoyu, Zhang, Qiang, Niu, Haichen, zheng, Yingwei, Liang, Mengyu, Deng, Mengqiong, Shi, Hao, Wang, Hao, Zhang, Fang, Zhu, Zuobin“…We also constructed a differentially expressed circRNA-lncRNA-miRNA-mRNA regulatory network and a ceRNA network affected by the mitochondrial variations. …”
Publicado 2020
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