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27221“…We further identified the lncRNA Rhno1 as a competing endogenous RNA (ceRNA) of miR-6979-5p, and we verified that it was able to influence osteoblast differentiation both in vitro and in vivo. …”
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27222por Lai, Mingfen, Liu, Guiju, Li, Ruijun, Bai, Hua, Zhao, Jizhi, Xiao, Peng, Mei, Jiazhuan“…In conclusion, hsa_circ_0079662, as a ceRNA binding with hsa‐mir‐324‐5p, can regulate target gene HOXA9 and induced the mechanism of chemotherapy drug oxaliplatin resistance in CRC through the TNF‐α pathway in human colon cancer.…”
Publicado 2020
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27223“…In this study, we consulted The Cancer Genome Atlas (TCGA) database to explore the functions and modulatory mechanisms of lncRNAs as competing endogenous RNAs (ceRNAs) in hepatocellular carcinoma (HCC) in Asian patients and constructed a risk scoring system composed of four lncRNAs (SNHG1, STEAP3‐AS1, RUSC1‐AS1, and SNHG3) to predict the outcomes of Asian patients with HCC. …”
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27224“…Through sponging miR‐7109, LINC00973 functioned as competing endogenous RNA (ceRNA) to control cell surface abundance of Siglec‐15, and, consequently, was involved in cancer immune suppression. …”
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27225“…Circ-0001068 was also delivered into T cells and induced PD1 expression by acting as a competing endogenous RNA (ceRNA) for miR-28-5p through the exosomes.…”
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27226por Liang, Junnan, Liao, Jingyu, Liu, Tongtong, Wang, Yu, Wen, Jingyuan, Cai, Ning, Huang, Zhao, Xu, Weiqi, Li, Ganxun, Ding, Zeyang, Zhang, Bixiang“…Then the competing endogenous RNA (ceRNA) network based on these DE RNAs was predicted and constructed. …”
Publicado 2020
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27227por Huang, Guanqun, Liang, Min, Liu, Haiyan, Huang, Jianhong, Li, Peiqing, Wang, Chong, Zhang, Yidan, Lin, Ye, Jiang, Xianhan“…Taken together, these findings indicated that circular RNA hsa_circRNA_104348 might function as a competing endogenous RNA (ceRNA) to promotes HCC progression by targeting miR-187–3p/RTKN2 axis and activating Wnt/β-catenin pathway.…”
Publicado 2020
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27228por Zhang, Peijing, Liu, Yongjing, Chen, Hongjun, Meng, Xianwen, Xue, Jitong, Chen, Kunsong, Chen, Ming“…In this study, we present CircPlant, an integrated tool for the exploration of plant circRNAs, potentially acting as competing endogenous RNAs (ceRNAs), and their potential functions. With the incorporation of several unique plant-specific criteria, CircPlant can accurately detect plant circRNAs from high-throughput RNA-seq data. …”
Publicado 2020
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27229“…Our results reveal a tumor-promoting role for PVT1, acting as a competing endogenous RNA (ceRNA) or a molecular sponge in negatively modulating miR-424, which might provide a novel therapeutic target for cervical cancer.…”
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27230“…In summary, our findings illustrate that CCAT2 acts as competing endogenous RNA (ceRNA) or sponge via negatively targeting miR-424, providing a novel diagnostic marker and therapeutic target for EOC.…”
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27231por Xia, Long, Chen, Xiaolong, Yang, Jiarui, Zhu, Shuguang, Zhang, Lei, Yin, Qi, Hong, Yueyu, Chen, Haoqi, Chen, Guihua, Li, Hua“…Mechanistically, lncRNA-PAICC acted as a competitive endogenous RNA (ceRNA) that directly sponged the tumor suppressive microRNAs miR-141-3p and miR-27a-3p. …”
Publicado 2021
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27232por YAMAZAKI, Yasunori“…An additional new post-decelerator, Extra Low ENergy Antiproton ring (ELENA), has been constructed and will be ready in 2021, which will provide 10–100 times more cold antiprotons to each experiment. …”
Publicado 2020
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27233“…In addition to the regulation mode of competitive endogenous RNA (ceRNA), circRNAs can also bind to RNA-binding proteins (RBPs), regulate alternative splicing, encode proteins or polypeptides, and regulate the expression of parent genes affecting biological pathways in which coded proteins are involved. …”
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27234“…Subsequent molecular investigations indicated that WNT5A was miR-1264’s target, and XIST functioned as a competing endogenous RNA (ceRNA) of miR-1264 to raise WNT5A expression. Further, an miR-1264 inhibitor stimulated the proliferation and suppressed the apoptosis of HA-VSMCs through the activation of WNT/β-catenin signaling. …”
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27235“…Taken together, our present study suggested a novel ceRNA network, in which SNHG12 could promote the malignancy of ccRCC although competitively binding with miR‐30a‐3p and consequently release the expression of its downstream cancer‐related genes.…”
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27236por Sun, Xinzhu, Liu, Dongyan, Ge, Nan, Guo, Jintao, Wang, Sheng, Liu, Xiang, Wang, Guoxin, Sun, Siyu“…Some circRNAs can act as “sponges” to adsorb microRNAs (miRNAs) and play the role of competitive endogenous RNA (ceRNA) to remove their inhibitory effects on the target genes of miRNA. …”
Publicado 2021
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27237“…Furthermore, PAXIP1-AS1 served as a competing endogenous RNA (ceRNA) to regulate PCBP2 expression by sponging microRNA-6744-5p (miR-6744-5p). …”
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27238Circular RNA circEGFR regulates tumor progression via the miR-106a-5p/DDX5 axis in colorectal cancer“…Mechanistically, circEGFR acted as a ceRNA for miR-106a-5p to relieve the repressive effect of miR-106a-5p on DDX5 mRNA. …”
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27239por Liu, Chen, Zhong, Liang, Shen, Chenlan, Chu, Xuan, Luo, Xu, Yu, Lihua, Ye, Jiao, Xiong, Ling, Dan, Wenran, Li, Jian, Liu, Beizhong“…The luciferase reporter assay coupled with RIP assay revealed that CRNDE act as a ceRNA. Rescue assays demonstrated that the effects of CRNDE silencing could be reversed by miR-136-5p inhibitors. …”
Publicado 2021
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27240“…Moreover, we identify a lncRNA (XLOC_028509), which is downregulated with Vibrio splendidus challenged, further study indicated that XLOC_028509 adsorb miR-2008 and miR-31 as competing endogenous RNAs (ceRNAs) through base complementarity, which in turn decreased the amount of miRNAs (microRNAs) bound to the 3’UTRs (untranslated regions) of mRNAs to reduce their inhibition of target gene translation. …”
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