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27781por Zhang, Mingyu, Jiang, Yuan, Guo, Xiaofei, Zhang, Bowen, Wu, Jiangjiao, Sun, Jiabin, Liang, Haihai, Shan, Hongli, Zhang, Yong, Liu, Jiaqi, Wang, Ying, Wang, Lu, Zhang, Rong, Yang, Baofeng, Xu, Chaoqian“…CHAR was found to act as a competitive endogenous RNA (ceRNA) to down‐regulate miR‐20b that we established as a pro‐hypertrophic miRNA. …”
Publicado 2019
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27782por Zhu, Qiaojuan, Li, Yazhao, Guo, Yang, Hu, Linjun, Xiao, Zunqiang, Liu, Xin, Wang, Jiahui, Xu, Qiuran, Tong, Xiangmin“…Mechanistically, SNHG16 directly interacted with miR‐497‐5p by acting as a competing endogenous RNA (ceRNA) and inversely regulated the abundance of miR‐497‐5p in DLBCL cells. …”
Publicado 2019
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27783“…Collectively, these data indicate that Malat1, as a competing endogenous RNA (ceRNA) for miR-150, derepresses eIF4E expression and activates Akt signaling, thereby being involved in PDGF-BB-induced ASMC proliferation and migration. …”
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27784por Liang, Chaojie, Yue, Chaosen, Liang, Chaowei, Ge, Hua, Wei, Zhigang, Li, Guangming, Wu, Jixiang, Huang, He, Guo, Jiansheng“…Luciferase reporter and gain- or loss-of-function assays indicated that SBF2-AS1 acted as a competing endogenous (ceRNA) for microRNA (miR)-302b-3p, which blocked the inhibitory effect of miR-302b-3p on the E2F transcription factor 3 (E2F3). …”
Publicado 2019
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27785“…CASC2 acted as competing endogenous RNA (ceRNA) for miR-155 to post-transcriptionally increase SOCS1 expression. …”
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27786“…Functionally, LOXL1‐AS1 acted as a ceRNA to upregulate USF1 via sponging miR‐708‐5p. …”
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27787por Zhan, Siyuan, Qin, Chenyu, Li, DanDan, Zhao, Wei, Nie, Lu, Cao, Jiaxue, Guo, Jiazhong, Zhong, Tao, Wang, Linjie, Li, Li, Zhang, Hongping“…Mechanistically, lncR-125b promotes SMSC differentiation by functioning as a competing endogenous RNA (ceRNA) for miR-125b to control IGF2 expression. These findings identify lncR-125b as a novel noncoding regulator of muscle cell differentiation and skeletal muscle development in goat.…”
Publicado 2019
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27788por Dai, Xinglong, Guo, Xiong, Liu, Jianjun, Cheng, Anqi, Peng, Xudong, Zha, Lang, Wang, Ziwei“…Bioinformatics analysis, fluorescence in situ hybridization, dual-luciferase reporter assay, RNA immunoprecipitation, RNA pull-down assay, and rescue experiments were conducted to confirm the underlying mechanisms of competitive endogenous RNAs (ceRNAs). We screened differentially expressed circRNAs and found that circGRAMD1B expression was downregulated in GC tissues and cell lines. …”
Publicado 2019
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27789por Song, Xinyue, Zhang, Xiaoxue, Wang, Xinnan, Chen, Lianze, Jiang, Longyang, Zheng, Ang, Zhang, Ming, Zhao, Lin, Wei, Minjie“…The mechanism of SPPRY4‐IT1 as a ceRNA was studied by a dual‐luciferase reporter assay and bioinformatic analysis. …”
Publicado 2019
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27790“…Eight interventions showed statistical significance: 3 pharmacological (Staphypan Berna, Poly(I):poly(C(12)U) and CoQ(10) + NADH) and 5 non-pharmacological therapies (cognitive-behavior-therapy-related treatments, graded-exercise-related therapies, rehabilitation, acupuncture and abdominal tuina). …”
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27791por Wang, Fang, Ji, Xin, Wang, Jingjing, Ma, Xiangrui, Yang, Yong, Zuo, Jinhua, Cui, Jun“…Mechanistic investigation revealed that PVT1 could positively regulate HIF1a expression via its competing endogenous RNA (ceRNA) activity on miR-194-5p. In addition, miR-194-5p conversely correlated with PVT1 and HIF1a expression in OSCC samples. …”
Publicado 2020
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27792“…These results indicated LINC00473 might act as a ceRNA to sponge miR-195-5p, thus promoting YAP1 and TEAD1 expressions, and shedding light on the underlying mechanisms of LINC00473-induced glioma progression.…”
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27793“…Functionally, MIR4435-2HG acted as a competing endogenous RNA (ceRNA) to upregulate YAP1 by sponging miR-206. Conclusions: MIR4435-2HG promoted CRC growth and metastasis through miR-206/YAP1 axis and is likely to play prognostic marker roles and be therapeutically targeted in CRC.…”
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27794por Wang, Shaobo, Qi, Yanhua, Gao, Xiao, Qiu, Wei, Liu, Qinglin, Guo, Xiaofan, Qian, Mingyu, Chen, Zihang, Zhang, Zongpu, Wang, Huizhi, Xu, Jianye, Xue, Hao, Guo, Xing, Zhang, Ping, Zhao, Rongrong, Li, Gang“…Further studies revealed that PDIA3P1 functions as a ceRNA, sponging miR-124-3p to modulate RELA expression and activate the downstream NF-κB pathway, thus promoting the MES transition of glioma cells. …”
Publicado 2020
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27795por Wu, Kun, Jiang, Yingying, Zhou, Wenkai, Zhang, Bolin, Li, Yan, Xie, Fei, Zhang, Jianjun, Wang, Xu, Yan, Ming, Xu, Qin, Ren, Zhenhu, Chen, Wantao, Cao, Wei“…Here, through multi-transcriptomics, bioinformatics analysis, and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), the co-expression network of long noncoding RNA RC3H2 (RC3H2), microRNA-101-3p (miR-101-3p), and EZH2 were screened and validated as a competing endogenous RNA (ceRNA) mechanism in OSCC. Silencing of RC3H2 inhibited OSCC cell proliferation, colony formation, migration, and invasion in vitro and reduced the expression of EZH2 and H3K27Me3, whereas RC3H2 overexpression significantly promoted OSCC cell growth, colony formation, migration, invasion, and xenograft tumor growth in vivo and increased the expression of EZH2 and H3K27Me3. …”
Publicado 2020
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27796por Hou, Xinran, Weng, Yingqi, Guo, Qulian, Ding, Zhuofeng, Wang, Jian, Dai, Jiajia, Wei, Anqi, Song, Zongbin“…Finally, we constructed a co-expression network and a ceRNA network of DEmRNAs and DElncRNAs to exhibit a potential regulatory mechanism of DElncRNAs, directly regulating protein coding gene expression in cis or in trans and indirectly regulating protein coding gene expression by sponging miRNA. …”
Publicado 2020
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27797por Liu, Fei, Hu, Lanting, Pei, Yi, Zheng, Ke, Wang, Wei, Li, Shenglong, Qiu, Enduo, Shang, Guanning, Zhang, Jiaming, Zhang, Xiaojing“…Moreover, AFAP1-AS1 was a ceRNA of RAI14 by competitively binding with miR-653-5p. …”
Publicado 2020
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27798“…Subsequently, 183 hub regulators were selected based on the analysis of node degree in the ceRNA network. Next, a comprehensive analysis of the subgroups and Wnt, mTOR, and MAPK signaling pathways was conducted to understand enrichment of the subgroups. …”
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27799“…Mechanistic analyses demonstrated that lncRNA EBLN3P functioned as a competing endogenous RNA (ceRNA) when regulating miR-204-5p in normal SGNs. …”
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27800por Ni, Chao, Fang, Qing-Qing, Chen, Wu-Zhen, Jiang, Jin-Xing, Jiang, Zhou, Ye, Jun, Zhang, Ting, Yang, Liu, Meng, Fan-Bo, Xia, Wen-Jie, Zhong, Miaochun, Huang, Jian“…Regarding the mechanism, SNHG16 served as a ceRNA by sponging miR-16–5p, which led to the derepression of its target gene SMAD5 and resulted in potentiation of the TGF-β1/SMAD5 pathway to upregulate CD73 expression in Vδ1 T cells. …”
Publicado 2020
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