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27901por Akad, Mona, Socolov, Răzvan, Furnică, Cristina, Covali, Roxana, Stan, Catalina Daniela, Crauciuc, Eduard, Pavaleanu, Ioana“…Materials and Methods: A prospective case-control study was conducted in “Elena Doamna” Hospital of Obstetrics and Gynecology between 4 January 2021 and 1 March 2022. …”
Publicado 2022
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27902“…SOX2-OT sponged to miR-455-3p and functioned as a ceRNA. In addition, phosphatase and tensin homolog (PTEN) served as an endogenous target of miR-455-3p to modulate the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway and disturb the alleviated consequence of miR-455-3p over-expression on LPS–induced BEAS-2B cell inflammation and cell injury. …”
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27903“…LINC00616 acted as a competitive endogenous RNA (ceRNA) to promote ferroptosis of PDLSCs via the miR-370/TFRC axis. …”
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27904por Zhang, Bowei, Li, Qiaoling, Song, Zhe, Ren, Li, Gu, Yi, Feng, Chao, Wang, Jinju, Liu, Tong“…Mechanistically, hsa_circ_0000285 induced the development of THCA via functioning as a competing endogenous RNA (ceRNA) of miR‐127‐5p to enhance CDH2 expression, which provided a new perspective for THCA therapy.…”
Publicado 2022
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27905“…Functional enrichment analysis was performed, and the protein–protein interaction (PPI) network, transcription factor (TF)-target interaction networks, and competitive endogenous RNA (ceRNA) regulatory networks were established for the DEGs. …”
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27906por Long, Niya, Xu, Xu, Lin, Hongyi, Lv, Ying, Zou, Shenghui, Cao, Han, Chen, Xueshu, Zhao, Yan, Qi, Xiaolan, Yang, Hua, Liu, Jian, Chu, Liangzhao“…Further, fluorescence in situ hybridization (FISH) assay, quantitative RT-PCR, and subcellular separation suggested that circPOSTN was predominately localized in the cytoplasm and may serve as a competing endogenous RNA (ceRNA). CircRNA-miRNA interaction prediction based on online analytical processing, AGO2-RIP assay, biotin labeled RNA pulldown assay, and dual-luciferase reporter assay revealed that circPOSTN sponged miR-219a-2-3p, limited its biological function, and ultimately upregulated their common downstream gene STC1. …”
Publicado 2022
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27907por Cheng, Quancheng, Wang, Jianwei, Li, Man, Fang, Jinyu, Ding, Huiru, Meng, Jieyi, Zhang, Junwei, Fang, Xuan, Liu, Huaicun, Ma, Chao, Chen, Chunhua, Zhang, Weiguang“…In vivo, the mechanistic analysis demonstrated that circSV2b overexpression resisted oxidative stress damage through the ceRNA-Akt1 axis in PD models. Taken together, these findings suggested that the miR-5107-5p-Foxk1-Akt1 axis might serve as a key target of circSV2b overexpression in PD treatment, and highlighted the significant change of circSV2b in serum exosomes. …”
Publicado 2022
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27908por Wang, Yaying, Pan, Yangyang, Wang, Meng, Afedo, Seth Yaw, Zhao, Ling, Han, Xiaohong, Liu, Minqing, Zhao, Tian, Zhang, Tongxiang, Ding, Tianyi, Wang, Jinglei, Cui, Yan, Yu, Sijiu“…Targeted regulation relationship pairs of 3β-HSD and MSTRG.54630.1, CNTLN and MSTRG.19058.1, BRCA2 and MSTRG.28299.4, CA2 and novel-miR-148, and ceRNA network of LAMC3-MSTRG.68870.1- bta-miR-7862/novel-miR-151/novel-miR-148 were constructed by Cytoscape software. …”
Publicado 2022
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27909“…Through a meta-analysis of the identified landscapes, novel competitive endogenous RNA (ceRNA) networks were constructed to reveal the potential molecular mechanisms that regulate the hallmarks of LSCs and LTCs. …”
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27910“…Notch, TGF-beta, and Wnt signaling pathways were also identified, which are conventional pathways associated with HF growth and development. Then, the ceRNA regulatory network was constructed, and the impact of lncRNA H19 was investigated in dermal papilla (DP) cells. …”
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27911por Zhao, Jie, Sun, Ye, Yang, Haojun, Qian, Jun, Zhou, Yan, Gong, Yu, Dai, Yi, Jiao, Yuwen, Zhu, Weiming, Wang, Honggang, Lin, Zhiliang, Tang, Liming“…The in vitro studies revealed that circGMCL1 mediates its effects on autophagy and NLRP3 inflammasome-mediated pyroptosis in epithelial cells through the ceRNA network. Moreover, the in vivo studies identified the therapeutic effect of PLGA MSs-carried oe-circGMCL1 in experimental colitis models. …”
Publicado 2022
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27912“…Furthermore, a competing endogenous RNA (ceRNA) interaction network centered on miR-22-3p revealed eight related transcription factors in the cardiovascular system. …”
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27913“…We also identified an lncRNA SNHG14/miR-20a-5p/CASP8 regulatory axis in bladder cancer by constructing a ceRNA network. Conclusion: We identified a PRG-associated prognostic signature associated with the prognosis and immune infiltrates for bladder cancer and targeting pyroptosis may be an alternative approach for therapy. …”
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27914por You, Xiangbin, Liu, Min, Liu, Qian, Li, Huijuan, Qu, Yilin, Gao, Xiaoxiao, Huang, Chengyu, Luo, Gan, Cao, Gang, Xu, Dequan“…NEAT1 acts as a competing endogenous lncRNA (ceRNA) to upregulate IL6 by attaching let-7 in PAMs. …”
Publicado 2022
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27915por Fabi, Alessandra, Fotia, Luana, Giuseppini, Federico, Gaeta, Arianna, Falcicchio, Chiara, Giuliani, Gabriele, Savarese, Antonella, Taraborelli, Emanuela, Rossi, Valentina, Malaguti, Paola, Giannarelli, Diana, Pugliese, Patrizia, Cognetti, Francesco“…AIM: The “Patient’s Dream” study was a two-arm randomized controlled trial conducted at the Regina Elena National Cancer Institute – IRCCS (Rome, Italy) from April 2019 to January 2020 to evaluate VRE impact in patients affected by breast or ovarian cancer. …”
Publicado 2022
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27916“…Then, a competing endogenous RNA (ceRNA) network, including 5 lncRNAs and 13 mRNAs, was constructed using lncRNA–mRNA pairs which share regulatory miRNAs and have significant correlation. …”
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27917por Cheng, Yi, Huang, Nan, Yin, Qingqing, Cheng, Chao, Chen, Dong, Gong, Chen, Xiong, Huihua, Zhao, Jing, Wang, Jianhua, Li, Xiaoyu, Zhang, Jing, Mao, Shuangshuang, Qin, Kai“…Competing endogenous RNA (ceRNA) network analysis demonstrated that TP53TG1 could act as the sponge of several miRNAs to regulate the expression level of target genes. …”
Publicado 2022
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27918por Braga, Eleonora A., Fridman, Marina V., Burdennyy, Alexey M., Filippova, Elena A., Loginov, Vitaly I., Pronina, Irina V., Dmitriev, Alexey A., Kushlinskii, Nikolay E.“…Epigenetic mechanisms play a significant role in the regulation of miR-124 expression and involve hypermethylation of the MIR-124-1/-2/-3 genes and the effects of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) according to the model of competing endogenous RNAs (ceRNAs). More than 40 interactomes (lncRNA/miR-124/mRNA) based on competition between lncRNAs and mRNAs for miR-124 binding have been identified in various epithelial cancers. …”
Publicado 2022
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27919por Jin, Xing, Zhang, Huan, Sui, Qihai, Li, Ming, Liang, Jiaqi, Hu, Zhengyang, Cheng, Ye, Zheng, Yuansheng, Chen, Zhencong, Lin, Miao, Wang, Hao, Zhan, Cheng“…R was used to explore the differential expressed protein-code gene, miRNA, and lncRNA, as well as their enriched functions and ceRNA networks. Additionally, the discrepancy between immune infiltration and genetic variation was comprehensively characterized. …”
Publicado 2022
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27920por Zhang, Yixin, Fan, Fan, Zhang, Qunjie, Luo, Yongjian, Liu, Qinjian, Gao, Jiadong, Liu, Jun, Chen, Guanghui, Zhang, Haiqing“…A competing endogenous RNA (ceRNA) network composed of 34 lncRNAs, 24 microRNAs (miRNA), and 161 mRNAs was obtained. …”
Publicado 2022
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