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28201por Zhou, Peng Li, Wu, Zhengyang, Zhang, Wenguang, Xu, Miao, Ren, Jianzhuang, Zhang, Qinhui, Sun, Zhanguo, Han, Xinwei“…Mechanistically, bioinformatics analysis, a dual-luciferase reporter assay, and anti-AGO2 RNA immunoprecipitation showed that circPDE3B could act as a competing endogenous RNA (ceRNA) by harboring miR-4766-5p to eliminate the inhibitory effect on the target gene laminin α1 (LAMA1). …”
Publicado 2021
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28202por Liu, Boqiang, Tian, Yuanshi, Chen, Mingyu, Shen, Hao, Xia, Jiafeng, Nan, Junjie, Yan, Tingting, Wang, Yifan, Shi, Liang, Shen, Bo, Yu, Hong, Cai, Xiujun“…Mechanistically, circUBAP2 acts as a competing endogenous RNA (ceRNA) for miR-194-3p, a tumor suppressor in HCC. …”
Publicado 2021
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28203“…Moreover, circMTO1 acted as a ceRNA of miR-182-5p to enhance RASA1 expression. …”
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28204“…Functional analysis in human breast cancer cell lines demonstrated that MALAT1 modulated breast cancer cell tumorigenicity by acting as a competing endogenous lncRNA (ceRNA) to regulate ST8SIA4 levels by sponging miR-26a/26b. …”
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28205por Zhen, Jingran, Li, Jiangli, Li, Xia, Wang, Xue, Xiao, Yaling, Sun, Zhengyi, Yu, Qi“…NEAT1 interference-mediated effect would be reversed by up-regulating miR-381. NEAT1 acted as a ceRNA to adsorb miR-381 to target IGF1. Overexpression of IGF1 reversed the inhibitory effect of miR-381 on ovarian granulosa cell apoptosis. …”
Publicado 2021
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28206por Yang, Deping, Yang, Bo, Zhu, Yanjun, Xia, Qianlin, Zhang, Yan, Zhu, Xin, Guo, Jianming, Ding, Tao, Zheng, Jianghua“…We further found that circDPP4 functioned as a competing endogenous RNA (ceRNA) for miR-195 in PCa cells, and miR-195 negatively regulated the expression of oncogenic cyclin D1. …”
Publicado 2021
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28207por Liu, Panpan, Zhang, Huali, Zeng, Haizhu, Meng, Yingxia, Gao, Hongchang, Zhang, Meilan, Zhao, Lei“…CASC2 overexpression alleviated CSE-induced apoptosis and inflammation in 16HBE cells. CASC2 functions as a ceRNA of miR-18a-5p. Upregulation of miR-18a-5p reversed the influence of CASC2 on cell apoptosis and inflammation in 16HBE cells. …”
Publicado 2021
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28208por Chen, Zihao, Li, Yong, Tan, Bibo, Li, Fang, Zhao, Qun, Fan, Liqiao, Zhang, Zhidong, Zhao, Xuefeng, Liu, Yu, Wang, Dong“…All investigations indicated that Lnc_ASNR functioned as a ceRNA targeting miR-519e-5p and facilitated GC development by regulating the pathway of miR-519e-5p/FGFR2.…”
Publicado 2021
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28209por Yang, Xu, Wu, Guixia, Yang, Fan, He, Lang, Xie, Xiaohui, Li, Lan, Yang, Lei, Ma, Yulan, Zhang, Qin, Chen, Jiao, Zou, SiYing, Han, Qian, Wang, Yan, Liu, Shuai, Li, Juan, Han, Bin, Liu, KaiJiang“…Besides, we demonstrated that LINC00909 functions as a competing endogenous RNA (ceRNA) of MRC2 mRNA by sponging miR-23-3p, and thereby promotes epithelial-to-mesenchymal transition (EMT) of ovarian cancer cells. …”
Publicado 2021
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28210por Mosaad, Manar, Elnaem, Mohamed Hassan, Cheema, Ejaz, Ibrahim, Ismail, Ab Rahman, Jamalludin, Kori, Ahlam Naila, Hin, How Soon“…In testicular germ cell tumours, Bezan et al RAM is a validated good discriminatory RAM for this malignancy subtype. …”
Publicado 2021
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28211“…This research is aimed at discovering the unknown lncRNA in MM through high-throughput sequencing and to study the mechanism and role of competitive endogenous RNA (ceRNA) involved in the pathogenesis of MM for the development of novel molecular markers and potential new targeted drugs. …”
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28212“…Mechanistically, AC016405.3 functioned as a competing endogenous RNA (ceRNA) for miR‐22‐3p in the cytoplasm and sponged miR‐22‐3p to release its suppression of ERBB3. …”
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28213“…Circular ribonucleic acids (circRNAs) are a class of novel stable and conserved forms of ribonucleic acids (RNAs). circRNAs have been documented to be involved in multiple diseases, especially malignancies, through a competing endogenous RNA (ceRNA) mechanism. However, few studies have been conducted on the function of circRNAs in TNBC. …”
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28214por Du, Chuang, Zhang, Jianhua, Zhang, Linfeng, Zhang, Yingying, Wang, Yan, Li, Jingruo“…CONCLUSIONS: Hsa_circ_102229 might serve as a competing endogenous RNA (ceRNA) to modulate PFTK1 expression via regulating miR‐152‐3p to affect the functions of TNBC cells. …”
Publicado 2021
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28215“…Kaplan–Meier estimator, receiver operating characteristic (ROC) curve and cox regression analysis were used to evaluate the prognostic value of circRNAs on recurrence-free survival (RFS) and overall survival (OS) in GC patients. CeRNA network prediction, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed for the circRNAs with prognostic significance. …”
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28216“…CONCLUSIONS: LINC00346 as a ceRNA played a carcinogenic role in the development of LUAD via miR-30c-2-3p/MYBL2 axis regulating the CELL CYCLE signaling pathway. …”
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28217por Zhang, Kai, Liu, Zixiang, Tang, Yingchuang, Shao, Xiaofeng, Hua, Xi, Liu, Hao, Yang, Huilin, Chen, Kangwu“…In vitro studies confirmed that NONHSAT114552 acted as ceRNA to regulate NRP1 by directly sponging miR-320d, thus facilitating chordoma cell proliferation and invasion. …”
Publicado 2021
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28218por Zhou, Jiahui, Wang, Lu, Sun, Qingyang, Chen, Ranran, Zhang, Chuan, Yang, Peng, Tan, Yuqian, Peng, Chaofan, Wang, Tuo, Jin, Chi, Ji, Jiangzhou, Jin, Kangpeng, Sun, Yueming“…Moreover, the mechanistic study showed that hsa_circ_0001666, acting as ‘ceRNA’ of miR‐576‐5p, prevented PCDH10 downregulation, as well as suppressed EMT and stemness of CRC cells, and the Wnt/β‐catenin signalling pathway. …”
Publicado 2021
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28219por Hou, Xinhua, Wang, Ligang, Zhao, Fuping, Liu, Xin, Gao, Hongmei, Shi, Lijun, Yan, Hua, Wang, Lixian, Zhang, Longchao“…SIMPLE SUMMARY: Variation exists in muscle-related traits, such as muscle growth and meat quality, between obese and lean pigs. In this study, the transcriptome profiles of skeletal muscle between Beijing Blackand Yorkshire pigs were characterized to explore the molecular mechanism underlying skeletal muscle-relatedtraits. …”
Publicado 2021
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28220por Socolov, Răzvan, Akad, Mona, Păvăleanu, Maricica, Popovici, Diana, Ciuhodaru, Mădălina, Covali, Roxana, Akad, Fawzy, Păvăleanu, Ioana“…Materials and Methods: We report the case of a 37-year-old primigesta primipara patient who was admitted to “Elena Doamna” Clinical Hospital of Obstetrics and Gynecology at 33 weeks and 3 days of gestation with high-grade multiple pregnancies (triplets) for threatened premature birth associated with COVID-19. …”
Publicado 2021
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