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28221“…GO classification, KEGG pathway, and ceRNA network analyses suggested that these differentially expressed circRNAs might play important roles in the etiopathogenesis of middle ear cholesteatoma. …”
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28222“…CONCLUSION: circABCB10 can promote the proliferation, invasion, and clonal formation of gastric cancer cells by targeting miR-1252-5p and upregulating the expression of MYC. circABCB10/miR-1252-5p/MYC constitutes the regulatory mechanism of ceRNA.…”
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28223por Lai, Shihui, Quan, Zhipeng, Hao, Yuesong, Liu, Jun, Wang, Zhiqian, Dai, Luo, Dai, Hongliang, He, Songqing, Tang, Bo“…Conclusion: LINC01572 acts as ceRNA of miR-195-5p to restrict its inhibition of PFKFB4, thereby enhancing glycolysis and activates PI3K/AKT signaling to trigger HCC malignancy.…”
Publicado 2021
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28224“…CONCLUSION: LncRNA HOTAIR promoted NP cell autophagy and apoptosis via promoting PTEN expression as a ceRNA of miR-148a in IDD.…”
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28225por Li, Dandan, Xu, Mengjie, Wang, Zidi, Huang, Pan, Huang, Congcong, Chen, Zhen, Tang, Gaijuan, Zhu, Xingji, Cai, Mengyu, Qin, Shanshan“…More importantly, transcriptome sequencing revealed a novel ceRNA network composed of NR2F1-AS1, miR-29a-3p, and VAMP7 in GC. …”
Publicado 2022
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28226“…To study the regulatory function of lncRNAs, a lncRNA-mediated ceRNA network was constructed, which showed that complex interactions of lncRNA–miRNA–mRNA may be a potential cause of EMT progression in gliomas. …”
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28227por Du, Peng, Luo, Kaifeng, Li, Guoyong, Zhu, Jisheng, Xiao, Qi, Li, Yong, Zhang, Xingjian“…Mechanistically, through bioinformatics analysis, we found that VCAN-AS1 functions as a competitive endogenous RNA (ceRNA) of miR-106a-5p, which targets the 3ʹ untranslated region (UTR) of signal transducer and activator of transcription 3 (STAT3). …”
Publicado 2021
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28228“…In-depth analysis showed that 4 hub mRNAs, 2 miRNAs, and 2 lncRNAs were potential crucial RNAs in the occurrence and development of cancer, and a competing endogenous RNA (ceRNA) network was then constructed. Finally, we identified CCNA2/MKI67/KIF11:miR-30a-5p:VPS9D1-AS1 axis-related cell cycle as a prognostic biomarker, which provided RNA cross-talks among mRNAs and non-coding RNAs (ncRNAs), especially at the multiple isomiR levels that further complicated the coding–non-coding RNA regulatory network. …”
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28229“…Cytoscape was applied to construct interaction and competitive endogenous RNA (ceRNA) networks. RESULTS: Gene Set Enrichment Analysis (GSEA) indicated that the genes in both the child and adult samples were primarily enriched in their immune-related functions. …”
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28230por Shi, Rui, Zhang, Wei, Zhang, Jun, Yu, Zhicheng, An, Lanfen, Zhao, Rong, Zhou, Xing, Wang, Ziwei, Wei, Sitian, Wang, Hongbo“…The mutual regulatory mechanism of ceRNAs was investigated using dual-luciferase reporter, RNA pulldown, RNA immunoprecipitation (RIP), and Western blot assays. …”
Publicado 2022
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28231LncRNA CALML3-AS1 suppresses papillary thyroid cancer progression via sponging miR-20a-5p/RBM38 axispor Zhang, Xiaozhou, Zhang, Xiaojian, Jia, Qian, Li, Hongqiang, Ma, Runsheng, Yang, Guang, Yin, Fengyan, Jiang, Nannan, Yin, Detao“…CONCLUSIONS: CALML3-AS1 functions as a ceRNA for miR-20a-5p in the regulation of the expression of RBM38 in PTC. …”
Publicado 2022
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28232“…Given that both FOXD3-AS1 and WEE1 contain a binding site for miR-128-3p, FOXD3-AS1 could act as a competing endogenous RNA (ceRNA) to promote WEE1 expression by sponging miR-128-3p. …”
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28233“…CONCLUSIONS: CircRNA circINTS4 may act as the ceRNA of miR-129-5p to regulate the expression of target gene POM121, thereby promoting the progress of TNBC molecular mechanism and providing scientific basis for circINTS4 as a new molecular target for clinical diagnosis and drug resistance therapy of TNBC.…”
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28234por Tang, Tingting, Yu, Sisi, Song, Zekai, Pan, Xiaofu, Xu, Fang, Wu, Yanke, Zhang, Liang“…Fourthly, we constructed a rectal cancer-related ceRNA network and detected several typical lncRNA-miRNA-mRNA crosstalk, such as HAND2-AS1, HAND2 and miR-20a-5p crosstalk and MBNL1-AS1, miR-429 and LONRF2 crosstalk, which were validated to function in improving overall survival of rectal cancer patients. …”
Publicado 2022
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28235“…Bioinformatics was performed to find the ceRNA regulatory network of STAT3/PCT. MALAT1 and miR‐125b were detected by qRT‐PCR. …”
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28236“…Next, lnc-ZNF32-1 : 1 and lnc-PCGF5-2 : 1 were selected for further validation of serum lncRNA expression in ACI and NC groups, and ceRNA interaction network analysis, diagnostic specificity, and sensitivity of lnc-ZNF32-1 : 1 and lnc-PCGF5-2 : 1 were conducted. …”
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28237“…Among them, circRNAs_1809 and Kitlg were the significantly increased circRNA and mRNA during osteogenic differentiation of rBMSCs. The ceRNA network showed that circRNA_1809 could target the Kitlg gene through miR-370-3p. …”
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28238por Han, Rongrong, Zhang, Peng, Li, Hongfang, Chen, Yun, Hao, Yongnan, Guo, Qiang, Zhang, Aimei, Li, Daojing“…A total of 261 lncRNA-miRNA relationship pairs and 21 circRNA-miRNA relationship pairs were obtained; additionally, 5 circRNAs and 13 lncRNAs were screened, which can be used as competing endogenous RNA (ceRNA) to compete with miRNA in the co-expression network. …”
Publicado 2022
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28239por Jiang, Shan, Chen, Jianfei, Li, Xiuli, Ren, Weike, Li, Fengxiang, Wang, Ting, Li, Cheng, Dong, Zhimin, Tian, Xiangxue, Zhang, Li, Wang, Lili, lu, Chao, Chi, Jingjing, Feng, Li, Yan, Minghua“…Competing endogenous RNA (ceRNA) regulatory networks among innate immunity-related ncRNAs and their target mRNAs were established. …”
Publicado 2022
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28240“…To provide a more experimental basis for later research, the hub genes which could be candidate biomarkers of BC and a ceRNA network related to them were obtained. And the potential mechanism of Syringin against BC was proved in vitro experiments. …”
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