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28361por Rong, Heng-Mo, Zhang, Chao, Rong, Guang-Sheng, Li, Ting, Qian, Xiao-Jun, Wang, Dong, Tong, Zhao-Hui“…Additionally, the immune-related lncRNA–miRNA–mRNA–ceRNA network was subsequently performed. The quantitative real-time PCR (RT-PCR) analysis was conducted to evaluate the lncRNA and mRNA expression profiles in WT-PCP mice and BAFF-R(–/–) PCP mice. …”
Publicado 2022
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28362“…Moreover, we conduct upstream miRNAs and lncRNAs of TOP2A to establish ceRNA networks in kidney renal clear cell carcinoma (SNHG3-miR-139-5p), kidney renal papillary cell carcinoma (TMEM147-AS1/N4BP2L2-IT2/THUMPD3-AS1/ERICD/TTN-AS1/SH3BP5-AS1/THRB-IT1/SNHG3/NEAT1-miR-139-5p), liver hepatocellular carcinoma (SNHG3/THUMPD3-AS1/NUTM2B-AS1/NUTM2A-AS1-miR-139-5p and SNHG6/GSEC/SNHG1/SNHG14/LINC00265/MIR3142HG-miR-101-3p) and lung adenocarcinoma (TYMSOS/HELLPAR/SNHG1/GSEC/SNHG6-miR-101-3p). …”
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28363“…The circACAP2 served as a ceRNA of miR-193a-5p and directly interacted with miR-193a-5p in cervical cancer cells. miR-193a-5p was able to target GPX4 and circACAP2 promoted GPX4 expression by sponging miR-193a-5p in cervical cancer cells. …”
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28364“…KCNQ1OT1 was found to be functioned as a ceRNA to bind and downregulate the expression of miR-128-3p that was upregulated in PA-induced cells. …”
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28365“…CRSRGPs were established based on stemness-related genes in the competing endogenous RNA (ceRNA) network. A CRSRGP signature was generated using the least absolute shrinkage and selection operator (Lasso) and Cox regression analysis of TCGA training set. …”
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28366“…CONCLUSION: Collectively, these findings demonstrate that GAS6-AS1 promotes TRIM14-mediated cell proliferation, migration, invasion, and EMT of CRC via ceRNA network and FUS-dependent manner, suggesting that GAS6-AS1 could be utilized as a novel biomarker and therapeutic target for CRC. …”
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28367por Zhao, Xiaoyu, Wu, Yingping, Li, Haiying, Li, Jiahui, Yao, Yingying, Cao, Yan, Mei, Zhiyong“…RESULTS: In this study, 4 ovary tissues at each breeding period of pre-laying (PP), laying (LP), and ceased-laying period (CP), respectively, with significant morphology difference, were used for RNA extraction and mRNAs, lncRNAs, and miRNAs comparison in Yili geese. CeRNA regulatory network was constructed for key genes screening. …”
Publicado 2022
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28368por Mo, Xiaocong, Hu, Di, Li, Yin, Nai, Aitao, Ma, Feng, Bashir, Shoaib, Jia, Guoxia, Xu, Meng“…In this study, a prognostic PRLs model and two ceRNA networks were established using sufficient bioinformatics analysis and preliminary RT-qPCR validation in vitro. 6 PRLs were identified to construct a prognostic model. …”
Publicado 2022
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28369“…Bioinformatics analysis showed that NEAT1 sponges miR-338-3p to form competing endogenous RNA (ceRNAs), which was verified by RNA pull-down assay and luciferase assay FLSs-RA had an increased rate of glutamine metabolism compared to normal FLSs increased compared to normal FLSs. …”
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28370“…Additionally, DSCAM-AS1, as a ceRNA, could regulate EZH2 expression via miR-138-5p. …”
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28371“…In addition, the lncRNA/miRNA/COL10A1 axis that may be involved in COL10A1 regulation in pancreatic cancer was explored by constructing a competitive endogenous RNA (ceRNA) regulatory axis. Finally, COL10A1 was analyzed for correlation with immune cell infiltration and various immune checkpoint molecules in pancreatic cancer. …”
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28372por Pei, Yanli, Wei, Yuxi, Peng, Boshizhang, Wang, Mengqi, Xu, Wei, Chen, Zhe, Ke, Xindi, Rong, Lei“…Finally, we constructed competing endogenous RNA (ceRNA) and protein–protein interaction (PPI) networks to delineate the interactions between PBMCs and exosomes within COPD. …”
Publicado 2022
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28373por Wang, Jun, Xiang, Yuan, Yang, Sheng-Xi, Zhang, Hui-Min, Li, Hui, Zong, Qi-Bei, Li, Le-Wei, Zhao, Li-Li, Xia, Ruo-Han, Li, Chao, Bao, Le-Yuan, Zhang, Tong-Cun, Liao, Xing-Hua“…Further mechanistic studies showed that, MIR99AHG functions as a competitive endogenous RNA (ceRNA) to antagonize miR-136-5p-mediated ubiquitin specific protease 4 (USP4) degradation, thereby unregulated the expression of angiotensin-converting enzyme 2 (ACE2), a downstream target gene of USP4, which in turn affected alveolar type II epithelial cell fibrosis and epithelial–mesenchymal transition (EMT). …”
Publicado 2022
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28374por Wu, Liyuan, Yin, Le, Ma, Linxiang, Yang, Jiarui, Yang, Feiya, Sun, Baofa, Nianzeng, Xing“…Besides, we established the competing endogenous RNA (ceRNA) diagram of lncRNAs-miRNAs-circular RNAs (circRNA) involved in the regulation of RRM2 expression. …”
Publicado 2022
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28375por Jiang, Baohong, Zhu, Hongbo, Feng, Wenjie, Wan, Zhixing, Qi, Xiaowen, He, Rongfang, Xie, Liming, Li, Yuehua“…METHODS: To construct a prognostic cuproptosis-related signature, LASSO Cox regression analysis was employed. Additionally, ceRNA was developed with an aim of exploring the possible lncRNA-miRNA-mRNA regulatory axis in breast cancer. …”
Publicado 2022
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28376por Wei, Cheng, Zhang, Xiaoyang, Peng, Dazhao, Zhang, Xu, Guo, Haizhen, Lu, Yalin, Luo, Lin, Wang, Bo, Li, Zesheng, He, Yingjie, Du, Xuezhi, Zhang, Shu, Liang, Hao, Li, Shenghui, Wang, Sheng, Han, Lei, Zhang, Jianning“…Above, oncogenic HOXA11-AS upregulates CTHRC1 expression as a ceRNA by adsorbing let-7b-5p, which activates c-Myc to regulate itself transcription. …”
Publicado 2022
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28377“…We anticipate that these poorly studied lncRNAs may act as enhancers (eRNA), regulating transcription and splicing, and in competition for miRNA binding (ceRNA). …”
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28378“…This study hypothesize that OSCC-CSC-derived small extracellular vesicles (OSCC-CSC-sEVs) transfer a ceRNA of miR-134 and consequently promote M2 macrophage polarization by targeting LAMC2 via the PI3K/AKT pathway through in vitro and in vivo experiment methods. …”
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28379“…Secondly, a Hub gene-based Gene-Drug regulatory network and a ceRNA regulatory network were successfully constructed. …”
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28380por Hu, Yaru, Han, Xue, Chen, Yue, Cai, Jinbiao, Li, Juan, Fan, Yuchen, Wang, Jianfeng, Xie, Shanglun“…OBJECTIVE: To investigate the function of MALAT1 in the inflammatory response, proliferation, migration, and epithelial-mesenchymal transition (EMT) of inflammatory and injured human lens epithelial cells (HLECs) and to reveal the underlying molecular signals. …”
Publicado 2023
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