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28581por Cao, Shuo, Zheng, Jian, Liu, Xiaobai, Liu, Yunhui, Ruan, Xuelei, Ma, Jun, Liu, Libo, Wang, Di, Yang, Chunqing, Cai, Heng, Li, Zhen, Feng, Ziyi, Xue, Yixue“…In addition, downregulated MIR17HG increased miR-346/miR-425-5p expression and MIR17HG acted as ceRNA to sponge miR-346/miR-425-5p. TAL1 was a direct target of miR-346/miR-425-5p, and played oncogenic role in glioma cells. …”
Publicado 2019
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28582por Wang, Yufeng, Yang, Liu, Chen, Tianxiang, Liu, Xin, Guo, Yang, Zhu, Qiaojuan, Tong, Xiangmin, Yang, Wei, Xu, Qiuran, Huang, Dongsheng, Tu, Kangsheng“…Mechanistically, MCM3AP-AS1 directly bound to miR-194-5p and acted as competing endogenous RNA (ceRNA), and subsequently facilitated miR-194-5p’s target gene forkhead box A1 (FOXA1) expression in HCC cells. …”
Publicado 2019
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28583por Ye, Hui, Wang, Xue, Wang, Lei, Chu, Xiaoying, Hu, Xuanxuan, Sun, Li, Jiang, Minghua, Wang, Hong, Wang, Zihan, Zhao, Han, Yang, Xinyu, Wang, Jianguang“…GO and KEGG analyses of the target genes predicted the biological functions of the 23 lincRNAs. q-PCR validation showed 7 lincRNAs and 2 novel lncRNAs were identical to the sequencing results. The ceRNA network contained 7 validated lincRNAs, 15 miRNAs, and 155 mRNAs. …”
Publicado 2019
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28584por Zhang, Zhuoran, Yin, Jianxing, Lu, Chenfei, Wei, Yutian, Zeng, Ailiang, You, Yongping“…SBF2-AS1 functions as a ceRNA for miR-151a-3p, leading to the disinhibition of its endogenous target, X-ray repair cross complementing 4 (XRCC4), which enhances DSB repair in GBM cells. …”
Publicado 2019
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28585por Liu, Zhikui, Wang, Yufeng, Wang, Liang, Yao, Bowen, Sun, Liankang, Liu, Runkun, Chen, Tianxiang, Niu, Yongshen, Tu, Kangsheng, Liu, Qingguang“…Further studies demonstrated that AGAP2-AS1 could function as a competing endogenous RNA (ceRNA) by sponging miR-16-5p in HCC cells. Functionally, gain- and loss-of-function studies showed that miR-16-5p promoted HCC progression and alteration of miR-16-5p abolished the promotive effects of AGAP2-AS1 on HCC cells. …”
Publicado 2019
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28586por Bansal, Rashika, Welch, James, Mandl, Adel, Cochran, Craig, Merkel, Roxanne, Tepede, Aisha, Weinstein, Lee, Simonds, William, Del Rivero, Jaydira, Kumar, Sheila, Nilubol, Naris, Patel, Dhaval, Agarwal, Sunita, Millo, Corina, Wank, Stephen, Blau, Jenny“…Special attention to identification of gastric mucosal nodules with well-controlled ZES is required as these lesions may rarely become malignant. Endnotes (i) Berna MJ, et al. A prospective study of gastric carcinoids and enterochromaffin-like cell changes in multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome: identification of risk factors. …”
Publicado 2019
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28587por Chen, Dafu, Chen, Huazhi, Du, Yu, Zhou, Dingding, Geng, Sihai, Wang, Haipeng, Wan, Jieqi, Xiong, Cuiling, Zheng, Yanzhen, Guo, Rui“…Additionally, hundreds of DElncRNAs and their target miRNAs were found to form complex competitive endogenous RNA (ceRNA) networks, suggesting that these DElncRNAs may act as miRNA sponges. …”
Publicado 2019
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28588por Zhang, Xiaoqian, Wen, Long, Chen, Shanwen, Zhang, Junling, Ma, Yongchen, Hu, Jianwen, Yue, Taohua, Wang, Jingui, Zhu, Jing, Bu, Dingfang, Wang, Xin“…In addition, CRART16 acts as a competing endogenous RNA (ceRNA) for miR-371a-5p to regulate V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (ERBB3) expression. …”
Publicado 2020
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28589“…Finally, a potential circRNA-miRNA-mRNA network was established based on competing endogenous RNA (ceRNA) hypothesis.…”
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28590por Zhang, Xiaofan, Gong, Wenci, Cao, Shengkui, Yin, Jianhai, Zhang, Jing, Cao, Jianping, Shen, Yujuan“…Furthermore, the target lncRNAs and mRNAs regulated by the 20 most abundant miRNAs were screened, and a ceRNA regulatory network containing 5 miRNAs, 41 lncRNAs, and 23 mRNAs was constructed, which provided new ideas and the molecular basis for further clarification of the function and mechanism of E. granulosus ELVs ncRNAs in the parasite–host interactions. …”
Publicado 2020
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28591por Sun, Cheng-Cao, Zhu, Wei, Li, Shu-Jun, Hu, Wei, Zhang, Jian, Zhuo, Yue, Zhang, Han, Wang, Juan, Zhang, Yu, Huang, Shao-Xin, He, Qi-Qiang, Li, De-Jia“…Moreover, we also found that LINC00301 could function as a competing endogenous RNA (ceRNA) against miR-1276 to expedite HIF1α expression in the cytoplasm of NSCLC cells. …”
Publicado 2020
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28592por Wang, Yao, Xiao, Shumin, Zhou, Saijun, Zhang, Rui, Liu, Hongyan, Lin, Yao, Yu, Pei“…Fluorescence in situ hybridization (FISH) was conducted to confirm subcellular localization of LncOR13C9 and a bioinformatics analysis was used to identify competing endogenous RNA (ceRNA) regulatory networks between LncOR13C9 and microRNA-23a-5p (miR-23a-5p). …”
Publicado 2020
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28593por Wang, Liang, Sun, Liankang, Liu, Runkun, Mo, Huanye, Niu, Yongshen, Chen, Tianxiang, Wang, Yufeng, Han, Shaoshan, Tu, Kangsheng, Liu, Qingguang“…Mechanistically, MAPKAPK5-AS1 upregulated PLAG1 like zinc finger 2 (PLAGL2) expression by acting as an endogenous competing RNA (ceRNA) to sponge miR-154-5p, thereby activating EGFR/AKT signaling. …”
Publicado 2021
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28594por Wen, Yan, Chun, Yao, Lian, Zhong Qing, Yong, Zhang Wei, Lan, Yang Mei, Huan, Liao, Xi, Chen Yi, Juan, Li Shu, Qing, Zhong Wen, Jia, Cheng, Ji, Zhang Huan“…Using bioinformatic analysis, a competing endogenous RNA (ceRNA) network was selected to study the regulatory roles of circRNA-0006896 in serum-Exos. …”
Publicado 2021
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28595“…We constructed a competing endogenous RNA (ceRNA) network. Several lncRNAs were predicted to regulate genes related to reproduction including cyp17a1, cyp19a1, mmp14, pgr, and hsd17b1. …”
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28596“…It was also shown that high expression of NEAT1 in oxygen-glucose deprivation (OGD)-treated human umbilical vein endothelial cells (HUVECs) functions as a competing endogenous RNA (ceRNA). By specifically binding miR-148b-3p, it weakened the negative regulatory effects of miR-148b-3p on the ICAM-1 target gene leading to upregulated expression of ICAM-1. …”
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28597“…Moreover, competitive endogenous RNA (ceRNA) network analysis revealed the target binding sites for miRNA such as oar-miR-27a, oar-miR-16b, oar-miR-200a/b/c, oar-miR-181a, oar-miR-10a/b, and oar-miR-432 in the identified DE-cirRNAs.…”
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28598por Yang, Fei, Zhang, Jie, Li, Baokun, Zhao, Zhijun, Liu, Yan, Zhao, Zhen, Jing, Shanghua, Wang, Guiying“…The regulatory network between optimal diagnostic lncRNA and mRNAs and optimal diagnostic miRNA and mRNAs was identified, followed by the construction of ceRNA network of lncRNA-mRNA-miRNA. Expression validation and diagnostic analysis of lncRNAs, miRNAs, and mRNAs were performed. …”
Publicado 2021
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28599por Liu, Tao, Shi, Qiao, Yang, Lei, Wang, Shusen, Song, Hongli, Wang, Zhenglu, Xu, Xinnv, Liu, Hongsheng, Zheng, Hong, Shen, Zhongyang“…HERH-4 acted as an miR-29b/c sponge to facilitate CCNA2 protein translation through a competing endogenous RNA (ceRNA) pathway. CONCLUSIONS: The oncogenic lncRNA HERH-1/4 promoted CCNA2 expression at the transcriptional and post-transcriptional levels and accelerated cell cycle progression in HCC cells. …”
Publicado 2021
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28600“…Co-expression networks among different types of RNA and competing endogenous RNA (ceRNA) regulatory networks were also constructed, and some genes involved in type I diabetes mellitus were found to play an important role in the complex molecular process of intramuscular fat deposition. …”
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