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421por Atkisson, Curtis“…We use data from the Apache Software Foundation Incubator program where 303 mentors have mentored 286 projects, with most mentoring more than one project, to address this question: Is who a project has as a mentor associated with variation in project success? …”
Publicado 2022
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424por Santos, Victória Laysna dos Anjos, Gonsalves, Arlan de Assis, Guimarães, Délis Galvão, Simplicio, Sidney Silva, de Oliveira, Helinando Pequeno, Ramos, Lara Polyana Silva, da Costa, Marcília Pinheiro, de Oliveira, Fátima de Cássia Evangelista, Pessoa, Claudia, Araújo, Cleônia Roberta Melo“…With this aim, a group of seven naphth[1,2-d]imidazole compounds were synthesized from β-lapachone. Their optical properties and their cytotoxic activity against cancer cells and their compounds were evaluated and confirmed promising values for molar absorptivity coefficients (on the order of 10(3) to 10(4)), intense fluorescence emissions in the blue region, and large Stokes shifts (20–103 nm). …”
Publicado 2023
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425por Park, Moon-Taek, Song, Min-Jeong, Lee, Hyemi, Oh, Eun-Taex, Choi, Bo-Hwa, Jeong, Seong-Yun, Choi, Eun-Kyung, Park, Heon Joo“…BACKGROUND: β-lapachone (β-lap), has been known to cause NQO1-dependnet death in cancer cells and sensitize cancer cells to ionizing radiation (IR). …”
Publicado 2011
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426por Lu, Christopher Y.“…So et al report that β-lapachone prevents this nephrotoxicity but not cisplatin’s cytotoxicity for cancers. …”
Publicado 2014
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427por Xu, Huanli, Chen, Qunying, Wang, Hong, Xu, Pingxiang, Yuan, Ru, Li, Xiaorong, Bai, Lu, Xue, Ming“…BACKGROUND: Lapachol is a natural naphthoquinone compound that possesses extensive biological activities. …”
Publicado 2016
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428por Cardoso, Mariana F. do C., Gomes, Ana T. P. C., Moreira, Caroline dos S., Simões, Mário M. Q., Neves, Maria G. P. M. S., da Rocha, David R., da Silva, Fernando de C., Moreirinha, Catarina, Almeida, Adelaide, Ferreira, Vitor F., Cavaleiro, José A. S.“…New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. …”
Publicado 2017
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429por Costa, Marcilia P., Feitosa, Anderson C. S., Oliveira, Fátima C. E., Cavalcanti, Bruno C., da Silva, Eufrânio N., Dias, Gleiston G., Sales, Francisco A. M., Sousa, Bruno L., Barroso-Neto, Ito L., Pessoa, Cláudia, Caetano, Ewerton W. S., Di Fiore, Stefano, Fischer, Rainer, Ladeira, Luiz O., Freire, Valder N.“…This study characterizes the encapsulation of Nor-β-lapachone (NβL) in poly(d,l-lactide-co-glycolide) (PLGA) microcapsules and evaluates the cytotoxicity of the resulting drug-loaded system against metastatic prostate cancer cells. …”
Publicado 2016
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430“…β-lapachone (β-lap) is reduced in tumor cells by the enzyme NAD(P)H: quinone acceptor oxidoreductase 1 (NQO1) to a labile hydroquinone which spontaneously reoxidises to β-lap, thereby generating reactive oxygen species (ROS) and oxidative stress. …”
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431por Shukla, Kirtikar, Singh, Naveen, Lewis, Joshua E., Tsang, Allen W., Boothman, David A., Kemp, Melissa L., Furdui, Cristina M.“…Radiation resistant rSCC-61 cells had increased sensitivity to β-lapachone compared to SCC-61 and knockdown of MTHFD2 in rSCC-61 cells further potentiated the cytotoxicity of β-lapachone with radiation in a dose and time-dependent manner. rSCC-61 MTHFD2 knockdown cells irradiated and treated with β-lapachone showed increased PARP1 activation, inhibition of mitochondrial respiration, decreased respiration-linked ATP production, and increased mitochondrial superoxide and protein oxidation as compared to control rSCC-61 scrambled shRNA. …”
Publicado 2020
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432por Ryu, Young-Kyoung, Park, Hye-Yeon, Go, Jun, Lee, In-Bok, Choi, Young-Keun, Lee, Chul-Ho, Kim, Kyoung-Shim“…Unilateral 6-OHDA-lesioned mice were treated with vehicle or β-Lapachone (10 mg/kg/day) and L-DOPA for 11 days. Abnormal involuntary movements (AIMs) were scored on days 5 and 10. β-Lapachone (10 mg/kg) co-treatment with L-DOPA decreased the AIMs score on both days 5 and 10. β-Lapachone was demonstrated to have a beneficial effect on the axial and limb AIMs scores on day 10. …”
Publicado 2021
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434“…Argentina hosts more than 30 Native American groups, who are widely distributed throughout the country. Mataco-Guaycurú speakers settled in the ecoregion of Gran Chaco and represent 26.7% of the extant aboriginal population of the country. …”
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435por García, Felipe E., Villagrán, Loreto, Ahumada, María Constanza, Inzunza, Nadia, Schuffeneger, Katherine, Garabito, Sandra“…In the Chilean context, the Mapuche people have historically suffered discrimination and violations of their rights. …”
Publicado 2021
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436por Muñoz, Enrique, Ros, Ana, Borja-Lloret, Marina, Barrio, John, Dendooven, Peter, Oliver, Josep F., Ozoemelam, Ikechi, Roser, Jorge, Llosá, Gabriela“…An active topic of investigation is the research of monitoring systems based on the detection of secondary radiation produced during treatment. MACACO, a multi-layer Compton camera based on LaBr(3) scintillator crystals and SiPMs, is being developed at IFIC-Valencia for this purpose. …”
Publicado 2021
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437“…Both APACHE II and APACHE IV had poor calibration. However, APACHE II calibrated better compared to APACHE IV.…”
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