“…The median (IQR) PaO(2)/FiO(2) ratio and APACHE II scores were 176 (151–191.5) and 14 (14–16), respectively. …”
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“…Multivariate logistic regression analysis showed that scores of APACHE II, SOFA, and ISS on admission, and MODS were independent risk factors for the occurrence of sepsis in patients with multiple traumas. …”
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“…The first location was in Spain where immigrant and Spanish students were enrolled, and the other was in Chile with Mapuche-Huilliche students, immigrant and Chilean students. …”
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“…Using an fMR-adaptation paradigm for different face morphing levels we have recently demonstrated a narrow neuronal tuning to faces even at the sub-exemplar level which was tightly related to perceptual discrimination (Gilaie-Dotan and Malach, 2007). However, it is unclear whether this relationship is unique to faces or is a general property of object representations including unfamiliar objects, and whether the adaptation tuning is due to physical changes in the stimulus or to changes in perceptual discrimination. …”
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“…The Niphta Theischinger fauna of South America is revised to include 11 species, nine of which are described as new to science (N.acus Pivar, sp. nov., N.bifurcata Pivar & Moulton, sp. nov., N.bispinosa Pivar & Sinclair, sp. nov., N.brunnea Pivar, sp. nov., N.courtneyi Pivar, sp. nov., N.daniellae Pivar, sp. nov., N.downesi Pivar, sp. nov., N.eurydactyla Pivar, sp. nov., N.mapuche Pivar, sp. nov.). The genus Niphta is redefined, both previously described Chilean species are redescribed, N.halteralis (Edwards) and N.nudipennis (Edwards), and females are described or redescribed where possible. …”
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“…By electron spin resonance experiments, we found that TcOYE specifically catalyzed one-electron reduction of menadione and β-lapachone to semiquinone-free radicals with concomitant generation of superoxide radical anions, while catalyzing solely the two-electron reduction of nifurtimox and 4-nitroquinoline-N-oxide drugs without free radical production. …”
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“…Despite extensive studies, the biological and pharmacological activities of SPION have not been exploited in therapeutic applications. Recently, β-lapachone (β-lap), a novel anticancer drug, has shown considerable cancer specificity by selectively increasing reactive oxygen species (ROS) stress in cancer cells. …”
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“…On the other hand, NQO1-mediated two-electron reduction converts certain quinone compounds (such as mitomycin C, E09, RH1 and β-lapachone) to cytotoxic agents, leading to cell death. …”
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“…Herein, we investigated the effect of β‐lapachone (β‐lap), a known plant‐derived metabolite that modulates cellular NAD(+) by conversion of NADH to NAD(+) via the enzymatic action of NADH: quinone oxidoreductase 1 (NQO1) on ARHL in C57BL/6 mice. …”
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“…Studies have shown that NQO1 can bioactivate certain quinone molecules (e.g., ortho-naphthoquinone and β-lapachone) to induce a futile redox cycle leading to the formation of oxidative DNA damage, hyperactivation of poly(ADP-ribose) polymerase 1 (PARP1), and catastrophic depletion of NAD(+) and ATP, which culminates in cellular lethality via NAD(+)-Keresis. …”
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“…The PLP-NPs comprised a reactive oxygen species (ROS)-sensitive polymeric paclitaxel (PTX) prodrug (DEX-TK-PTX), a pH-sensitive poly(l-histidine) (PHis), and beta-lapachone (Lapa), a ROS-generating agent. We found that PLP-NPs could accumulate in tumor tissue through enhancement of the permeability and retention (EPR) effect, and were subsequently internalized by cancer cells via the endocytic pathway. …”
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“…The structurally related β-lapachones promote neutrophil recruitment but do not affect resolution. …”
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“…Plant bioactive ingredients were curcumin, betulinic acid, artemisinin, 4-nitrobenzaldehyde thiosemicarbazone, andrographolide, pentalinonsterol, ursolic acid, amarogentin, carvacrol, 14-deoxy-11-oxo-andrographolide, quercetin, beta-lapachone, cedrol, 2′,6′-dihydroxy-4′-methoxychalcone, and oleanolic acid. …”
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“…Mean (standard deviation) age was 59.3 (13.9) years, 39.7% of patients were women, and median [IQR] APACHE-II (acute physiologic assessment and chronic health evaluation) score was 30 [25-34]. …”
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“…Older patients received less sedation, had higher APACHE II scores and mortality (36.1%) and 18.5% were discharged home. …”
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“…The 30-day mortality rate was associated with APACHE II score ≥15 (OR 3.27, 95% CI 1.45–7.39) and septic shock (OR 2.53, 95% CI 1.36–4.69). …”
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“…Subgroup analyses of age (< 65 years or >  = 65 years), Acute Physiology and Chronic Health Evaluation (APACHE) score (< 59 or >  = 59), gender, ventilation (yes or no), and vasopressor (yes or no) in patients with lung cancer were conducted. …”
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“…Antibiotics used to treat PA, including dose, interval, and MIC data were evaluated. Finally, admission APACHE II score and hospital mortality were collected. …”
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“…All consecutive patients admitted to the three ICUs between 2004 and 2007 were included in the study, except for patients who did not fulfil APACHE II criteria (readmissions, burns, cardiac surgery, younger than 16 years, length of stay less than 8 hours). …”
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