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  1. 10181
    “…Logistic models were fitted to predict treatment at baseline using the following variables: age, sex, obesity, non-respiratory Sequential Organ Failure Assessment score, APACHE-II, C-reactive protein, days from symptoms onset to HFNO initiation, respiratory rate, and peripheral oxyhemoglobin saturation. …”
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    Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study
  2. 10182
    “…RESULTS: Mean age was 62.6 years, 70.5% were male, 52.0% were white, 39.2% obese and 9.0% had serious comorbidities. Median APACHE II score was 16 (IQR 12, 19). After 60 days, 83 (41.5%) patients had been discharged from hospital, 15 (7.5%) had been discharged from critical care but remained in hospital, 1 (0.5%) was still receiving critical care, 90 (45.0%) had died while receiving critical care and 11 (5.5%) had died in hospital after discharge from critical care. …”
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    Critical care outcomes, for the first 200 patients with confirmed COVID-19, in England, Wales and Northern Ireland: A report from the ICNARC Case Mix Programme
  3. 10183
    por Zhang, Zhongheng, Zheng, Bin, Liu, Nan
    Publicado 2020
    “…The DTR model used a backward induction algorithm to estimate the sequence of optimal rules. 22,868 patients who had sepsis according to the Acute Physiology and Chronic Health Evaluation (APACHE) IV diagnosis group were included. Optimal fluid management (liberal [> 40 ml/kg/d] versus restricted [< 40 ml/kg/d]) strategy were developed on the Day 1, 3 and 5 after ICU admission according to current states and treatment history. …”
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    Individualized fluid administration for critically ill patients with sepsis with an interpretable dynamic treatment regimen model
  4. 10184
    “…Results: Patients were males (88.2%) aged 51 [interquartile range (IQR): 42.5–58.75)], with admission Acute Physiology and Chronic Health Evaluation (APACHE) 4 score of 53 (IQR: 37.75–72.5), and had more than one comorbidity (62.3%). …”
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    Tocilizumab in the treatment of rapidly evolving COVID-19 pneumonia and multifaceted critical illness: A retrospective case series
  5. 10185
    “…RESULTS: A total of 43 patients were included (G1 = 28 [65.1%], G2 = 10 [23.3%] and G3 = 5[11.6%]), with a mean age of 65 years (range 52-72), 62% males, APACHE II 18 (15-24), SOFA 6 (4-7). Arterial hypertension (30.2%) and obesity (25.6%) were the most frequent comorbidities. …”
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    Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic()
  6. 10186
    “…METHODS: We developed CIDACS-RL (Centre for Data and Knowledge Integration for Health – Record Linkage), a novel iterative deterministic record linkage algorithm based on a combination of indexing search and scoring algorithms (provided by Apache Lucene). We described how the algorithm works and compared its performance with four open source linkage tools (AtyImo, Febrl, FRIL and RecLink) in terms of sensitivity and positive predictive value using gold standard dataset. …”
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    CIDACS-RL: a novel indexing search and scoring-based record linkage system for huge datasets with high accuracy and scalability
  7. 10187
    “…Age, underlying diseases, especially hypertension and coronary heart disease, elevated D-dimer, decreased hemoglobin, and SOFA score, and APACH score also need to be taken into account for predicting disease progression. …”
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    Clinical Features for Severely and Critically Ill Patients with COVID-19 in Shandong: A Retrospective Cohort Study
  8. 10188
    “…ESRD patients had a higher median Charlson Comorbidity score (5 vs 2, P < .001), higher median acute physiology and chronic health evaluation (APACHE) II score (26.5 vs 20.0, P < .001), and lower 6‐hour intravenous fluid administration (54.7 vs 68.3 mL/kg, P < .001). …”
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    Outcomes of end‐stage renal disease patients in the PROCESS trial
  9. 10189
    “…Age, diabetes mellitus, immunosuppression, lymphopenia, high D-Dimer levels, increased APACHE II and SOFA scores, invasive mechanical ventilation and use of inotropic or vasopressor support were significantly associated with AKI. …”
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    Clinical characteristics and outcome of critically ill COVID-19 patients with acute kidney injury: a single centre cohort study
  10. 10190
    “…While concentrations of interleukin 6 and 8 were not different between groups, markers of epithelial cell injury (soluble receptor for advanced glycation end products, sRAGE) and acute phase proteins (serum amyloid A, SAA) were significantly higher in COVID-19 compared to non-COVID-19, adjusting for demographics and APACHE III scores. In contrast, angiopoietin 2:1 (Ang-2:1 ratio) and soluble tumor necrosis factor receptor 1 (sTNFR-1), markers of endothelial dysfunction and inflammation, were significantly lower in COVID-19 (p < 0.002). …”
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    Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study
  11. 10191
    “…Persistent severe AKI was associated with chronic kidney disease, diabetes mellitus, higher non-renal APACHE III score, greater fluid balance, vasopressor use, and greater change in baseline serum creatinine. …”
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    External validation of urinary C–C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury
  12. 10192
    “…Other factors such as drug and alcohol misuse and macho attitudes to violence, highly prevalent among men in this socially excluded community, also contributed. …”
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    Interpersonal violence in a deprived Scottish urban area with aggregations of physical health risks and psychiatric morbidity: an ecological study
  13. 10193
    “…Cases (patients with LwBW (body mass index (BMI) < 18.5 kg/m(2))) were matched with normal body weight controls (NBW) (patients with BMI ≥ 18.5 kg/m(2) and ≤30 kg/m(2))) by age, gender, baseline renal function and severity status (APACHE II score). A 100% fT > MIC was considered an optimal pharmacokinetic/pharmacodynamic (PK/PD) target and 100% fT > 10 × MIC as supratherapeutic exposure. …”
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    Pharmacokinetics and Pharmacodynamics of Meropenem by Extended or Continuous Infusion in Low Body Weight Critically Ill Patients
  14. 10194
    “…MÉTODOS: Um total de 242 ratos machos pesando entre 200 e 250g foram submetidos a um procedimento cirúrgico (ligação da artéria coronária ou cirurgia simulada). …”
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    Influência do Consumo de Suco de Laranja (Citrus Sinensis) na Remodelação Cardíaca de Ratos Submetidos a Infarto do Miocárdio
  15. 10195
    “…MÉTODOS: Foram utilizados 60 ratos Wistar machos distribuídos em quatro grupos: Controle (C), Exercício Físico (EF), Dieta Intermitente (DI) e Exercício Físico e Dieta Intermitente (EDI). …”
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    Dieta Intermitente Atenua a Remodelação Cardíaca Causada pelo Exercício Físico
  16. 10196
    “…When patients entered the ICU, their oxygenation index (t: 30885, P < 0.01), APACHE II score (t: 2.105, P < 0.05), and SOFA score (t: 4.134, P < 0.001) were higher in the death group than the survival group. …”
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    Correlation Analysis between Mechanical Power and Lung Ultrasound Score and Their Evaluation of Severity and Prognosis in ARDS Patients
  17. 10197
    por Ollier, Joseph, Neff, Simon, Dworschak, Christine, Sejdiji, Arber, Santhanam, Prabhakaran, Keller, Roman, Xiao, Grace, Asisof, Alina, Rüegger, Dominik, Bérubé, Caterina, Hilfiker Tomas, Lena, Neff, Joël, Yao, Jiali, Alattas, Aishah, Varela-Mato, Veronica, Pitkethly, Amanda, Vara, Mª Dolores, Herrero, Rocío, Baños, Rosa Mª, Parada, Carolina, Agatheswaran, Rajashree Sundaram, Villalobos, Victor, Keller, Olivia Clare, Chan, Wai Sze, Mishra, Varun, Jacobson, Nicholas, Stanger, Catherine, He, Xinming, von Wyl, Viktor, Weidt, Steffi, Haug, Severin, Schaub, Michael, Kleim, Birgit, Barth, Jürgen, Witt, Claudia, Scholz, Urte, Fleisch, Elgar, von Wangenheim, Florian, Car, Lorainne Tudor, Müller-Riemenschneider, Falk, Hauser-Ulrich, Sandra, Asomoza, Alejandra Núñez, Salamanca-Sanabria, Alicia, Mair, Jacqueline Louise, Kowatsch, Tobias
    Publicado 2021
    “…The Elena+ intervention is open-source under the Apache 2 license (MobileCoach software) and the Creative Commons 4.0 license CC BY-NC-SA (intervention logic and content), allowing future collaborations; such as cultural adaptions, integration of new sensor-related features or the development of new topics. …”
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    Elena+ Care for COVID-19, a Pandemic Lifestyle Care Intervention: Intervention Design and Study Protocol
  18. 10198
    “…In the univariate analysis, the risk factors for 30-day mortality were Charlson index, refractory underlying disease, use of steroids, polimicrobial bacteremia, Staphylococcus aureus, GNB resistant to carbapenems, APACHE and Pitt scores, hypotension, respiratory source and ICU admission. …”
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    945. Bacteremia in Patients with Solid Tumors: Epidemiology, Clinical Features and Risk Factors for Mortality. Results from a Multicenter Study in Argentina
  19. 10199
    “…Patients were comparable in terms of age, and APACHE II score. Out of 19 BSI CoVID-19 patients, 14 (73%) were male vs 5 (50%) in the non-CoVID-19 BSI patients (p=0.0007). …”
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    189. Bacteremia among COVID-19 and Non-Covid-19 Patients Admitted in the ICU
  20. 10200
    “…Comparing these periods, weekly admissions declined (median [Q1 Q3] 160 [145,168] to 113 [98.5,134]; p<0.001); unit turnover declined (median [Q1 Q3] 12.1 [11.32,13] to 8.58 [7.24,10], p<0.001), and APACHE II score increased (median [Q1 Q3] 19 [19,20] to 21 [20,22] ; p<0.001). …”
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    Impact of COVID-19 on non-COVID intensive care unit service utilization, case mix and outcomes: A registry-based analysis from India
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