“…Thus, the well-known bone-targeting drugs 3-amino-1-hydroxypropane-1,1-bisphosphonic acid (pamidronic acid, SI-1), 4-amino-1-hydroxybutane-1,1-bisphosphonic acid (alendronic acid, SI-2), 5-amino-1-hydroxypentane-1,1-bisphosphonic acid (SI-3), and hydroxyphenylmethylene-1,1-bisphosphonic acid (fenidronic acid, SI-6) are studied along with novel, specially designed bisphosphonates (1,4-dihydroxybutane-1,1,4,4-tetrayl)tetrakisphosphonic acid (SI-4), (1,6-dihydroxyhexane-1,1,6,6-tetrayl)tetrakisphosphonic acid (SI-5), and ((4- aminophenyl)(hydroxy)methylene)bisphosphonic acid (SI-7) in a dynamic tube-blocking scale rig at 100 °C and 80 bar according to typical North Sea conditions. …”
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“…Moreover, selective activation of Epac-dependent signaling promoted adipocyte differentiation when the Rho-associated kinase (ROCK) was inhibited. Unlike the case for murine preadipocytes cell lines, long-chain fatty acids, like arachidonic acid, did not promote adipocyte differentiation of hMADS cells in the absence of a PPARγ agonist. …”
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“…Mathematical introduction : arithmetic and algebra ; geometry, trigonometry, and analytic geometry ; calculus ; matter and force ; the Earth as an astronomical body ; the celestial sphere and measurement of time ; Moon and eclipses ; the solar system and celestial mechanics ; energy and work ; heat and the kinetic molecular theory ; the atomic constitution of matter ; electricity and magnetism ; electrical nature of matter ; wave motion and light ; electromagnetic waves ; spectra ; astronomical spectroscopy : astrophysics ; properties of more important elements ; oxidation and reduction ; reaction velocity and chemical equilibrium ; ionogens : acids, bases, salts ; atomic structure and chemical behavior ; electromotive series of the elements ; carbon and its compounds ; silicon and the structure of rocks ; Earth materials and processes ; gradation ; geologic work of the ocean : the sedimentary rocks ; diastrophism and earthquakes ; volcanism, the deep-seated rocks, and the rock cycle ; principles of Earth history ; fossils and ancient climates ; geological time ; geosynclines and mountains ; pre-cambrian and early paleozoic times ; late paleozoic and the Appalachian revolution ; the mesozoic era ; the cenozoic era ; mapping the Earth ; weather and weather maps ; climate ; nature of soils.…”
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“…Pyhäsalmi mine in central Finland provides an excellent opportunity to study microbial and geochemical processes in a deep subsurface crystalline rock environment through near-vertical drill holes that reach to a depth of more than two kilometers below the surface. …”
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“…Deep fractured rock ecosystems across most of North America have not been studied extensively. …”
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“…Co-precipitation assays revealed that the central region (amino acids 330–1057) of Solo binds to the C-terminal region (1451–1752) of β4-integrin. …”
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“…BACKGROUND: Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. …”
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“…These alterations can be induced by rock–fluid interactions which are affected by well operations such as acidizing, stimulation, gas injections, and so forth. …”
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“…RESULTS: LPA, a potent stimulator of the Rho-ROCK pathway, surprisingly did not require the Rho-ROCK pathway to stimulate migration but instead utilized Rac and MAPK. …”
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“…The FIC domain played a key role in BepC-induced stress fiber formation and cell fragmentation because deletion of FIC signature motif or mutation of two conserved amino acid residues abolished BepC-induced cell fragmentation. …”
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“…Iron ions (sourced from the underlying rock) in the crystallization medium inhibits the moolooite formation. …”
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“…The objective of this study was to investigate the use of the acid production potential (AP) calculation factor and seven different S analysis methods in the preliminary mine waste characterization by analyzing and comparing 48 Finnish mine waste samples. …”
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“…The concentration of rare earth elements (REEs) in geological materials including SLRS-6 (natural water certified reference material) and JB1b, JA1, and JG2 (Standard Rock Materials of Geological Survey of Japan) can be used as a tracer to characterize various geochemical processes in earth systems. …”
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“…A 75 bp fragment encoding 25 amino acid residues was amplified from cDNA of these five bivalves and was named “Molluskin.” …”
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“…The combination system of multinanoscale highly efficient stimulation fluid and mud acid can meet the optimal dissolution rate of rock during the acidizing process and can increase the permeability of the targeted reservoir by 2.68 times, with a remarkable field application effect. …”
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“…Our experiments show that SYGT effectively reduces the acid–rock reaction rate and filtration loss under harsh working conditions such as high temperature, strong shear, high salinity, and a high concentration of acid. …”
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“…RESULTS: Struvite had greatly enhanced solubility in the presence of organic acid anions; buckwheat, which exudes a high level of organic acids, was more effective at mobilising struvite P than the low level exuder, spring wheat. …”
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“…Isolate UDJA102x89-9, identified as Klebsiella variicola (KV), showed phosphate-solubilizing ability and produced high amounts of several organic acids in vitro and of indole-3-acetic acid (IAA). …”
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“…Phylogenetic analysis using ITS and LSU rDNA regions revealed a wide diversity of rock-inhabiting fungal strains within the sampled areas. …”
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“…Cigarette smoke extract (CSE) induced ER stress in J774 macrophages and RhoA activation in J774 cells, and the CSE-induced ROCK activity was successfully reversed by GSK2606414 and tauroursodeoxycholic acid. …”
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