“…LPA increased Rho-associated protein kinase 2 (ROCK2) expression and PI3K/AKT activation; moreover, the pharmacological inhibition of ROCK2 and PI3K/AKT signaling suppressed LPA-induced cell cycle progression. …”
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“…Quite different from the Canadian oil sands, the Indonesian asphalt rocks proved to be carbonate unconventional oil ores. …”
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“…In this work, a rigid-flexible combined impeller was applied to the leaching process of phosphate rock to increase the leaching efficiency. The effects of the reaction temperature (T), sulfuric acid excess coefficient (ε), liquid–solid ratio (L/S), agitation speed (N), and leaching time (t) on the leaching of phosphate rock were investigated, and based on this, the leaching kinetics was studied. …”
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“…Herein, we present a new approach for reducing the use of DMSO in cryopreservation by using biodegradable hyaluronic acids (HAs). By adding HAs into cryoprotectant media containing a low concentration of DMSO, higher cell viability and cell proliferation rate were observed upon thawing after cryopreservation. …”
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“…In this work, we summarize various sample digestion and combined preconcentration methods for the determination of gold amounts in rocks. They include fire assay, fire assay combined with Te coprecipitation and instrumental neutron activation analysis (INAA) or laser ablation inductively coupled plasma mass spectrometry, fusion combined with Te coprecipitation and anion exchange resins, dry chlorination, wet acid digestion combined with precipitation, ion exchange resins, solvent extraction, polyurethane foam, extraction chromatography, novel solid adsorbents, and direct determination by INAA. …”
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“…A pro-inflammatory lipid mediator, lysophosphatidic acid (LPA), is a potent activator of the Rho/ROCK signalling pathway and has been shown to induce the expression of chemokines and cell adhesion molecules (CAMs). …”
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“…Finally, YQFM inhibited the expression of ROCK-1 and phosphorylation of MLC induced by Dasatinib. …”
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“…Rac and RhoA (through Rho Kinase (ROCK)). Using pharmacological inhibitors, we tested how inhibition of Rac and ROCK influenced osteoblast adhesion, differentiation and mineralization on PT (Pre-treated) and SLA (sandblasted large grit, acid etched) topographies. …”
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“…In conclusion, mineralization by human osteosarcoma Saos-2 cells seems to be differently regulated by Src and ROCK kinases.…”
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“…Degrading permafrost in pristine periglacial environments can produce acid rock drainage (ARD) and cause severe ecological damage in areas underlain by sulfide‐bearing bedrock. …”
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“…In contrast, the pH of the leachates from the cover method gradually increased from strongly acidic (pH ~ 2) to mildly acidic (pH ~ 4–5) and circumneutral (pH ~ 7) along with a decrease in EC and elemental leaching. …”
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“…Results show that different roasting had not caused significant difference on contents of soluble solids, total polyphenols, flavonoids, soluble sugar, thearubigins and theabrownins, while it slightly regulated caffeine, proteins and theaflavins, and remarkably reduced catechins and free amino acids. The ratio of polyphenol content/amino acid content, a negative-correlated indicator of fresh and brisk taste, significantly increased with the increase of roasting degree. …”
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“…Roasting led to the enrichment of 342 N metabolites, including 34 lipids, 17 organic acids, 32 alkaloids and 25 amino acids, as well as secondary derivatives beneficial for tea quality. …”
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“…Therefore, we analyzed the effect of ROCK inhibition using Y-27632 in a model of peripheral axonal damage in the spiral ganglion neurons created using the glutamate agonists, N-methyl-D-aspartate (NMDA) and kainic acid, to induce excitotoxic trauma in the explanted cochlea. …”
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“…The best available technology for preventing the formation of acid drainage water from the sulfidic waste rock at mine closure aims to limit the oxygen access to the waste. …”
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“…Abl-dependent down-regulation of Rap1-GTP causes cell rounding and detachment only when the Rho–ROCK1 pathway is also activated, for example, by lysophosphatidic acid (LPA). …”
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“…In addition, these analyses indicated that the erosion via rock weathering was also affected by atmospherically derived CO(2) and allogenic acids. …”
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“…Genomic analysis of these bacteria revealed the presence of genes related to P uptake and metabolism, and to organic acid synthesis. Using this approach, we identified six potential candidates as bioinoculants, which are promising for use under field conditions, as they have both the genetic potential and the experimentally demonstrated in vivo ability to improve rock phosphate solubilization and promote plant growth.…”
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“…We conducted a two-seasons experiment to evaluate soil phosphorus availability and exchangeable aluminum in response to phosphate rock and organic inputs in acidic humic nitisols. …”
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