“…Two available smallpox vaccines are part of the strategic stockpile in the United States; one is a replication-deficient modified vaccinia Ankara vaccine (MVA), and the other is a replication-competent smallpox vaccine (ACAM2000). …”
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“…BACKGROUND: Viral vectors, including adenovirus (Ad) and modified vaccinia Ankara (MVA), have gained increasing attention as vaccine platforms in recent years due to their capacity to express antigens from a wide array of pathogens, their rapid induction of humoral and cellular protective immune responses, and their relatively low production costs. …”
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“…METHODS: Using a mixed-methods longitudinal design, we recruited children with developmental difficulties aged 0–42 months with an appointment during the first lockdown at Ankara University Developmental Pediatrics Division and seen face-to-face only once before. …”
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“…SETTING: Pandemic clinic of Gazi University Hospital, Ankara, Turkey. PARTICIPANTS: 76 adult COVID-19 patients (aged >18 years) were enrolled in the study between March 2021 and May 2021 (N=76). …”
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“…The research was conducted in April 2021 with 637 married Syrian refugee women aged 15-49 living in Ankara (mean age: 29.6). The median age at first marriage was 17, and consanguinity with her spouse was 29.8%. 8.6% were illiterate. 36.3% did not/could not benefit from public hospitals free of charge, and 89.8% did not have health insurance. 96.7% had a previous pregnancy (median:4). …”
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“…Kuwait, Dubai, and Muscat), the megacities (e.g. Tehran, Ankara, and Istanbul) exhibited anomalous increases in the intensity of daytime SUHI, which may exceed 2 °C. …”
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“…Here, we develop and validate an eDNA assay using quantitative PCR for E. chisholmensis, E. naufragia, and E. tonkawae. These three species are federally threatened and constitute the Septentriomolge clade that occurs in the northern segment of the Edwards Aquifer. …”
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“…Significant higher MetS prevalence ratios were found in Jakarta (PR 1.826; 95CI 1.628–2.048), West Nusa Tenggara (PR 1.412; 95CI: 1.222–1.630), West Sumatra (PR 1.404; 95CI: 1.202–1.641), East Java province (PR 1.109; 95CI: 1.001–1.229) and in Sasak (PR 1.532; 95CI:1.304–1.800), Minangkabau (PR 1.469; 95CI:1.251–1.726), Betawi (PR 1.597; 95CI:1.346–1.895), Acehnese ethnic group (PR 2.101; 95CI:1.099–4.020) while significant lower prevalence ratios were observed in Central Java (PR 0.668; 95CI: 0.580–0.770), Yogyakarta (PR 0.695; 95CI: 0.575–0.840), Banten (PR 0.718; 95CI: 0.533–0.968), Bali province (PR 0.724; 95CI: 0.590–0.889) and in Javanese (PR 0.855; 95CI:0.788–0.928), also Balinese ethnic groups (PR 0.669; 95CI:0.535–0.836). …”
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“…METHODS: The prospective cohort study was conducted as a follow up study measuring the impact of PCV13 demonstration program by the Indonesian Ministry of Health in Lombok Island, West Nusa Tenggara, Indonesia, from March 2018 to June 2019. …”
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“…Since the gametocyte is the only transmissible stage from human host to mosquito vector, this study evaluated the pre and post presence of gametocytes during a mass screening and treatment (MST) intervention conducted during 2013 in East Nusa Tenggara, Indonesia. METHODS: RT-qPCR targeting pfs25 and pvs25 transcripts—gametocyte molecular markers for Plasmodium falciparum and Plasmodium vivax, respectively, was performed to detect and quantify gametocytes in blood samples of P. falciparum and P. vivax-infected subjects over the course of the MST study. …”
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“…SNP mutation pvmdr1 Y976F reached 96.1% in Papua and East Nusa Tenggara. Polymorphism analysis in the pfdhfr gene revealed 94/111 (84.7%) double mutants S108N/C59R or S108T/A16V in Central Java. …”
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“…Methodology The study was designed retrospectively, and the records of patients who were followed up and treated at Ankara University Faculty of Medicine, Medical Oncology Clinic, between January 1, 2011, and December 31, 2021, were reviewed. …”
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“…BACKGROUND AND AIMS: Modified Vaccinia virus Ankara (MVA) represents a promising vaccine vector for respiratory administration to induce protective lung immunity including tertiary lymphoid structure, the bronchus-associated lymphoid tissue (BALT). …”
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“…We tested the reactivity of serum IgG from Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN)-vaccinated (n = 12) and convalescent mpox-infected (n = 5) individuals and uninfected, non-vaccinated controls (n = 32) to MPXV/VACV proteins A27, A29, A30, A35, B16, B21, C19, D6, E8, H3, I1, and L1. …”
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“…Grinspoon, MD, Theratechnologies: Grant/Research Support Takara Stanley, MD, Pfizer, Inc: Grant/Research Support Lindsay Fourman, MD, Amryt Pharmaceuticals: Advisor/Consultant|Amryt Pharmaceuticals: Grant/Research Support…”
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“…FFM ME-TRAP is sequential immunisation with two attenuated poxvirus vectors (FP9 and modified vaccinia virus Ankara), which both deliver the pre-erythrocytic malaria antigen construct multiple epitope–thrombospondin-related adhesion protein (ME-TRAP). …”
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“…Based on these findings we performed a long-term toxicity and immunogenicity study of Nef, encoded either by Modified Vaccinia virus Ankara or by plasmid DNA. BALB/c mice were primed twice with either DNA or MVA encoding Nef and received a homologous or heterologous boost ten months later. …”
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“…METHODS: For this cross-sectional survey, the study population was selected from among physicians and dentists in Ankara. All of the 373 participants were given a self-administered questionnaire. …”
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“…METHODS: Three Chinese cynomolgus macaques were immunised via intramuscular injections using a regimen composed of a prime with two DNA vaccines expressing clade A Env/clade B Gag followed by boosting with recombinant fowlpox virus expressing HIV-1 clade D Gag, Env and cholera toxin B subunit followed by the final boost with recombinant modified vaccinia virus Ankara expressing HIV-1 clade C Env, Gag and human complement protein C3d. …”
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“…We recently demonstrated in a mouse model for human smallpox, that active immunization 2–3 days p.e. with either VACV-Lister or modified VACV Ankara (MVA) vaccines, can rescue animals from lethal challenge of ectromelia virus (ECTV), the causative agent of mousepox. …”
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