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  1. 17461
    “…The number of participants achieving a goal of 10 000+ steps per day increased from 15.3% before to 27.5% after (odds ratio, 2.06; 95% CI, 1.70–2.50). Increased PA was also observed in subgroups, with the largest increases seen in participants who spent more time playing Pokémon GO, those who were overweight/obese, or those with a lower baseline PA level. …”
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  2. 17462
  3. 17463
    “…We have previously shown that ONC201 targets self-renewing, chemotherapy-resistant colorectal CSCs via Akt/ERK inhibition and DR5/TRAIL induction. In this study, we demonstrate that the anti-CSC effects of ONC201 involve early changes in stem cell-related gene expression prior to tumor cell death induction. …”
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  4. 17464
  5. 17465
  6. 17466
  7. 17467
    “…Traditional approaches to drug discovery are frustratingly inefficient and have several key limitations that severely constrain our capacity to rapidly identify and develop novel experimental therapeutics. …”
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  8. 17468
  9. 17469
  10. 17470
  11. 17471
  12. 17472
    por Miller, Jeremy A, Guillozet-Bongaarts, Angela, Gibbons, Laura E, Postupna, Nadia, Renz, Anne, Beller, Allison E, Sunkin, Susan M, Ng, Lydia, Rose, Shannon E, Smith, Kimberly A, Szafer, Aaron, Barber, Chris, Bertagnolli, Darren, Bickley, Kristopher, Brouner, Krissy, Caldejon, Shiella, Chapin, Mike, Chua, Mindy L, Coleman, Natalie M, Cudaback, Eiron, Cuhaciyan, Christine, Dalley, Rachel A, Dee, Nick, Desta, Tsega, Dolbeare, Tim A, Dotson, Nadezhda I, Fisher, Michael, Gaudreault, Nathalie, Gee, Garrett, Gilbert, Terri L, Goldy, Jeff, Griffin, Fiona, Habel, Caroline, Haradon, Zeb, Hejazinia, Nika, Hellstern, Leanne L, Horvath, Steve, Howard, Kim, Howard, Robert, Johal, Justin, Jorstad, Nikolas L, Josephsen, Samuel R, Kuan, Chihchau L, Lai, Florence, Lee, Eric, Lee, Felix, Lemon, Tracy, Li, Xianwu, Marshall, Desiree A, Melchor, Jose, Mukherjee, Shubhabrata, Nyhus, Julie, Pendergraft, Julie, Potekhina, Lydia, Rha, Elizabeth Y, Rice, Samantha, Rosen, David, Sapru, Abharika, Schantz, Aimee, Shen, Elaine, Sherfield, Emily, Shi, Shu, Sodt, Andy J, Thatra, Nivretta, Tieu, Michael, Wilson, Angela M, Montine, Thomas J, Larson, Eric B, Bernard, Amy, Crane, Paul K, Ellenbogen, Richard G, Keene, C Dirk, Lein, Ed
    Publicado 2017
    “…Treatments targeting specific pathologies such as amyloid beta in Alzheimer’s disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology and cognitive abilities with advancing age, indicative of individual variation in resilience to pathology. …”
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  13. 17473
    “…Key facilitating factors for implementation were positive organisational climate, adequate training and teacher's and pupil’s motivation. Barriers to implementation included heavy workloads, budget cuts and lack of resources or support. …”
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  14. 17474
  15. 17475
  16. 17476
  17. 17477
  18. 17478
  19. 17479
  20. 17480
    “…As a result, the μ-calpain gene and its specific inhibitor, calpastatin, have been repeatedly investigated for their association with meat quality traits in cattle; however, no functional mutation has been identified for these two genes. …”
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