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C‐terminal Cysteines of CueR Act as Auxiliary Metal Site Ligands upon Hg$^{II}$ Binding—A Mechanism To Prevent Transcriptional Activation by Divalent Metal Ions?
Intracellular CuI is controlled by the transcriptional regulator CueR, which effectively discriminates between monovalent and divalent metal ions. It is intriguing that HgII does not activate transcription, as bis-thiolate metal sites exhibit high affinity for HgII. Here the binding of HgII to CueR...
| Autores principales: | , , , , , , |
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| Lenguaje: | eng |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://dx.doi.org/10.1002/chem.201902940 http://cds.cern.ch/record/2778382 |