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PET in vivo generators $^{134}$Ce and $^{140}$Nd on an internalizing monoclonal antibody probe
The in vivo-generator radionuclides $^{140}$Nd (t$_{1/2}$ = 3.4 d) and $^{134}$Ce (t$_{1/2}$ = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-r...
| Autores principales: | , , , , , , , , |
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| Lenguaje: | eng |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://dx.doi.org/10.1038/s41598-022-07147-x http://cds.cern.ch/record/2803753 |