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PET in vivo generators $^{134}$Ce and $^{140}$Nd on an internalizing monoclonal antibody probe

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The in vivo-generator radionuclides $^{140}$Nd (t$_{1/2}$ = 3.4 d) and $^{134}$Ce (t$_{1/2}$ = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-r...

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Detalles Bibliográficos
Autores principales:	Severin, G W, Fonslet, J, Kristensen, L K, Nielsen, C H, Jensen, A I, Kjær, A, Mazar, A P, Johnston, K, Köster, U
Lenguaje:	eng
Publicado:	2022
Materias:	Physics in General
Acceso en línea:	https://dx.doi.org/10.1038/s41598-022-07147-x http://cds.cern.ch/record/2803753

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