CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells

Overexpression of S100B is routinely used for disease-staging and for determining prognostic outcomes in patients with malignant melanoma. Intracellular interactions between S100B and wild-type (WT)-p53 have been demonstrated to limit the availability of free WT-p53 in tumor cells, inhibiting the ap...

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Detalles Bibliográficos
Autores principales: Roy Choudhury, Samrat, Heflin, Billie, Taylor, Erin, Koss, Brian, Avaritt, Nathan L., Tackett, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000373/
https://www.ncbi.nlm.nih.gov/pubmed/36899866
http://dx.doi.org/10.3390/cells12050730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000373/
https://www.ncbi.nlm.nih.gov/pubmed/36899866
http://dx.doi.org/10.3390/cells12050730

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