Urokinase-Type Plasminogen Activator Receptor (uPAR) Cooperates with Mutated KRAS in Regulating Cellular Plasticity and Gemcitabine Response in Pancreatic Adenocarcinomas

SIMPLE SUMMARY: Pancreatic ductal adenocarcinomas (PDACs) with gene amplification or overexpression of urokinase-type plasminogen activator receptor (uPAR) have a particularly dismal prognosis. We show here that uPAR reinforces the MEK/ERK signaling pathway in tumor cells with a KRAS mutation with t...

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Detalles Bibliográficos
Autores principales: Peng, Luogen, Li, Yuchan, Yao, Sha, Gaedcke, Jochen, Baart, Victor M., Sier, Cornelis F. M., Neesse, Albrecht, Ellenrieder, Volker, Bohnenberger, Hanibal, Fuchs, Frieder, Kitz, Julia, Ströbel, Philipp, Küffer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000455/
https://www.ncbi.nlm.nih.gov/pubmed/36900379
http://dx.doi.org/10.3390/cancers15051587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000455/
https://www.ncbi.nlm.nih.gov/pubmed/36900379
http://dx.doi.org/10.3390/cancers15051587

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