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Heparan Sulfates Regulate Axonal Excitability and Context Generalization through Ca(2+)/Calmodulin-Dependent Protein Kinase II

Our previous studies demonstrated that enzymatic removal of highly sulfated heparan sulfates with heparinase 1 impaired axonal excitability and reduced expression of ankyrin G at the axon initial segments in the CA1 region of the hippocampus ex vivo, impaired context discrimination in vivo, and incr...

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Detalles Bibliográficos
Autores principales: Song, Inseon, Kuznetsova, Tatiana, Baidoe-Ansah, David, Mirzapourdelavar, Hadi, Senkov, Oleg, Hayani, Hussam, Mironov, Andrey, Kaushik, Rahul, Druzin, Michael, Johansson, Staffan, Dityatev, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000602/
https://www.ncbi.nlm.nih.gov/pubmed/36899880
http://dx.doi.org/10.3390/cells12050744