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What Is the Significance of Lysosomal-Mediated Resistance to Imatinib?
The lysosomal sequestration of hydrophobic weak-base anticancer drugs is one proposed mechanism for the reduced availability of these drugs at target sites, resulting in a marked decrease in cytotoxicity and consequent resistance. While this subject is receiving increasing emphasis, it is so far onl...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000661/ https://www.ncbi.nlm.nih.gov/pubmed/36899844 http://dx.doi.org/10.3390/cells12050709 |