Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy

SIMPLE SUMMARY: Colorectal cancer is a leading cause of cancer-related deaths, mainly caused by resistance to therapy and metastatic spread, in turn sustained by the activation of mechanisms such as the epithelial-to-mesenchymal transition (EMT). We investigate here the role of the Hedgehog-GLI and...

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Detalles Bibliográficos
Autores principales: Citarella, Anna, Catanzaro, Giuseppina, Besharat, Zein Mersini, Trocchianesi, Sofia, Barbagallo, Federica, Gosti, Giorgio, Leonetti, Marco, Di Fiore, Annamaria, Coppola, Lucia, Autilio, Tanja Milena, Spinello, Zaira, Vacca, Alessandra, De Smaele, Enrico, Venneri, Mary Anna, Ferretti, Elisabetta, Masuelli, Laura, Po, Agnese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000782/
https://www.ncbi.nlm.nih.gov/pubmed/36900263
http://dx.doi.org/10.3390/cancers15051471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000782/
https://www.ncbi.nlm.nih.gov/pubmed/36900263
http://dx.doi.org/10.3390/cancers15051471

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