Therapy-Acquired Clonal Mutations in Thiopurine Drug-Response Genes Drive Majority of Early Relapses in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Methods: Forty pediatric (0–12 years) B-ALL DNA samples (20 paired Diagnosis-Relapse) and an additional six B-ALL DNA samples (without relapse at 3 years post treatment), as the non-relapse arm, were retrieved from the biobank for advanced genomic analysis. Deep sequencing (1050–5000X; mean 1600X) w...

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Detalles Bibliográficos
Autores principales: Thakur, Rozy, Bhatia, Prateek, Singh, Minu, Sreedharanunni, Sreejesh, Sharma, Pankaj, Singh, Aditya, Trehan, Amita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001400/
https://www.ncbi.nlm.nih.gov/pubmed/36900028
http://dx.doi.org/10.3390/diagnostics13050884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001400/
https://www.ncbi.nlm.nih.gov/pubmed/36900028
http://dx.doi.org/10.3390/diagnostics13050884

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