Artificial Intelligence-Based Computational Screening and Functional Assays Identify Candidate Small Molecule Antagonists of PTPmu-Dependent Adhesion

PTPmu (PTPµ) is a member of the receptor protein tyrosine phosphatase IIb family that participates in cell-cell adhesion and signaling. PTPmu is proteolytically downregulated in glioblastoma (glioma), and the resulting extracellular and intracellular fragments are believed to stimulate cancer cell g...

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Detalles Bibliográficos
Autores principales: Molyneaux, Kathleen, Laggner, Christian, Brady-Kalnay, Susann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001486/
https://www.ncbi.nlm.nih.gov/pubmed/36901713
http://dx.doi.org/10.3390/ijms24054274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001486/
https://www.ncbi.nlm.nih.gov/pubmed/36901713
http://dx.doi.org/10.3390/ijms24054274

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