Transformation of a Metal Chelate into a “Catch and Anchor” Inhibitor of Botulinum A Protease

Targeting the botulinum neurotoxin light chain (LC) metalloprotease using small-molecule metal chelate inhibitors is a promising approach to counter the effects of the lethal toxin. However, to overcome the pitfalls associated with simple reversible metal chelate inhibitors, it is crucial to investi...

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Detalles Bibliográficos
Autores principales: Lin, Lucy, Patel, Ealin N., Nielsen, Alexander L., Turner, Lewis D., Tepp, William H., Nguyen, Kong, Pellett, Sabine, Janda, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001950/
https://www.ncbi.nlm.nih.gov/pubmed/36901734
http://dx.doi.org/10.3390/ijms24054303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001950/
https://www.ncbi.nlm.nih.gov/pubmed/36901734
http://dx.doi.org/10.3390/ijms24054303

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