Structural Basis of the Binding Mode of the Antineoplastic Compound Motixafortide (BL-8040) in the CXCR4 Chemokine Receptor

Modulation of the CXCL12–CXCR4 signaling axis is of the utmost importance due to its central involvement in several pathological disorders, including inflammatory diseases and cancer. Among the different currently available drugs that inhibit CXCR4 activation, motixafortide—a best-in-class antagonis...

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Detalles Bibliográficos
Autores principales: Rebolledo-Bustillo, Mariana, Garcia-Gomez, David, Dávila, Eliud Morales, Castro, María Eugenia, Caballero, Norma A., Melendez, Francisco J., Baizabal-Aguirre, Victor M., Sanchez-Gaytan, Brenda L., Perez-Aguilar, Jose Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001991/
https://www.ncbi.nlm.nih.gov/pubmed/36901829
http://dx.doi.org/10.3390/ijms24054393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10001991/
https://www.ncbi.nlm.nih.gov/pubmed/36901829
http://dx.doi.org/10.3390/ijms24054393

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